DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC39A6 and foi

DIOPT Version :9

Sequence 1:	NP_036451.4	Gene:	SLC39A6 / 25800	HGNCID:	18607	Length:	755	Species:	Homo sapiens
Sequence 2:	NP_001261584.1	Gene:	foi / 38976	FlyBaseID:	FBgn0024236	Length:	706	Species:	Drosophila melanogaster

Alignment Length:	814	Identity:	225/814 - (27%)
Similarity:	340/814 - (41%)	Gaps:	277/814 - (34%)

- Green bases have known domain annotations that are detailed below.

Human    12 TFALSVTNPLHELKAAAFPQTTEKISPNWESGINVDLAISTRQYHLQQLFYRYGENNSLSVEGFR 76
            ||..|::.|....|..|    ..:..|..||.:.     ...||:|::|.   .::..::..||.
  Fly    72 TFNYSISPPSRREKRHA----GHEHGPTSESRVP-----QITQYYLEKLM---AQDELMNSSGFD 124

Human    77 KLLQNIGIDKI------------KRIHIHH--DHDHHSDHEHHSDHERHSDHEHHSEHEHHSDHD 127
            .|||.:.:..:            .|: :||  .||||              |.|     ||.:.|
  Fly   125 GLLQQLSLHSLASGASEGTCVPGSRL-VHHVQPHDHH--------------HAH-----HHEEED 169

Human   128 HHSHHNHAASGKN--KRKALC---PDHDSDSSGKDPRNSQGKGAHRPEHASGRRNVKDSVSASEV 187
            |....|:....:|  ....:|   |::::...||:.:|.
  Fly   170 HSLQLNNCTLIQNGTTSNVICPSLPNNNTHPLGKEAKNF-------------------------- 208

Human   188 TSTVYNTVSEGTHFLETIETPRPGKLFPKDVSSSTPPSVTSKSRVSRLAGRKTNESVSEPRKGFM 252
                  |:|:                  ||:.
  Fly   209 ------TLSD------------------KDLL--------------------------------- 216

Human   253 YSRNTNENPQECFNASKLLTSHGMGIQVPLNATEFNYLCPAIINQIDARS--CL-------IHTS 308
                                                :|||.::.::.|:|  |:       |.|:
  Fly   217 ------------------------------------HLCPILLYELKAQSGGCIEPAILSDIDTT 245

Human   309 EKKAEIPPKTYSLQIAWVGGFIAISIISFLSLLGVILVPLMNRVFFKFLLSFLVALAVGTLSGDA 373
            |:..| ..|...:...|:..||::.....|.|:||.::|.|...::|:::.:||||||||::|||
  Fly   246 EELLE-AEKDKDIFYVWIYAFISVFACGILGLVGVAIIPFMGSRYYKYIIQYLVALAVGTMTGDA 309

Human   374 FLHLLPHSHASHHHSHSHEEPAMEMKRGPLFSHLSSQNIEESAYFDSTWKGLTALGGLYFMFLVE 438
            .|||||||.|      ..:|..|.|                        |||..|||:.|.:::|
  Fly   310 LLHLLPHSLA------GQDERGMIM------------------------KGLGCLGGIIFFYVME 344

Human   439 HVLTLIKQF-KDKKKKNQKKPE-----NDDDVEIKKQLS-------KYES------QLSTNEEKV 484
            |.||:|.:: |..:||..|||.     .|.|..:...::       ||.|      :::.|.::.
  Fly   345 HALTMISEWRKSVEKKETKKPSRAKVMRDPDSSVNNSVAGDKICKQKYSSYPYCYDEITMNNKQS 409

Human   485 D----TDDRTEGYLRADSQEPS----------HFDSQQPAVLEEEEVMIAHAHPQEVYNEYVPRG 535
            :    ..|...|   |....||          |..|...|...|.  :|:..|...|...:....
  Fly   410 EWMHLPFDVAAG---AGGDAPSVAELRNGVGDHDGSNDMAAAAES--LISPLHTNCVEMNHHNHN 469

Human   536 CKNKCHSHFHDTLGQSDDLI------------------HHHHDYHHILHHHHHQNHHPHSHSQRY 582
            .|:..|...|:  ||..:.|                  ...:|:..::...|..:||.|||  |:
  Fly   470 HKHNSHQQNHE--GQDSNTIVTDLDGNAVYAVNKAKDKDSRNDHVTVILREHESSHHGHSH--RH 530

Human   583 SREELKDAGVATLAWMVIMGDGLHNFSDGLAIGAAFTEGLSSGLSTSVAVFCHELPHELGDFAVL 647
            .........::.:|||:|||||||||:||:||||||.|.::.|.|||:|||||||||||||||:|
  Fly   531 GHVHSPPETLSAVAWMIIMGDGLHNFTDGMAIGAAFAENIAGGFSTSLAVFCHELPHELGDFAIL 595

Human   648 LKAGMTVKQAVLYNALSAMLAYLGMATGIFIGHYAENVSMWIFALTAGLFMYVALVDMVPEMLHN 712
            :||||:||.||.||.|:.:|:::||..||..|. :::|:.|:||:.||||:|:|||||:||:
  Fly   596 IKAGMSVKSAVYYNLLTGVLSFIGMIFGIAFGQ-SQDVAQWMFAVAAGLFIYIALVDMMPEI--- 656

Human   713 DASDHGCSRWGYFFLQNAGMLLGFGIMLLISIFE 746
             ::.|  ...|.|.||..|||.|.||||||:::|
  Fly   657 -SASH--KSLGQFLLQILGMLSGVGIMLLIALYE 687

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC39A6	NP_036451.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	95..186		17/95 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	202..246		2/43 (5%)
		Zip	323..742	CDD:308248	169/469 (36%)
foi	NP_001261584.1	Zip	258..684	CDD:280666	170/471 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	195	1.000	Domainoid score	I3166
eggNOG	1	0.900	-	-		E1_COG0428
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	327	1.000	Inparanoid score	I2474
Isobase	1	0.950	-	0	Normalized mean entropy	S3931
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D461652at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41192
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12191
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4006
SonicParanoid	1	1.000	-	-		X2614
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.910