Protein Alignment SLC39A6 and foi

DIOPT Version :10

• Sequence 1: NP_036451.4
• Gene: SLC39A6 / 25800
• HGNCID: 18607
• Length: 755
• Species: Homo sapiens
• Sequence 2: NP_523974.3
• Gene: foi / 38976
• FlyBaseID: FBgn0024236
• Length: 706
• Species: Drosophila melanogaster
• Alignment Length: 814
• Identity: 225/814 - (27%)
• Similarity: 340/814 - (41%)
• Gaps: 277/814 - (34%)

Human    12 TFALSVTNPLHELKAAAFPQTTEKISPNWESGINVDLAISTRQYHLQQLFYRYGENNSLSVEGFR 76
            ||..|::.|....|..|    ..:..|..||.:.     ...||:|::|.   .::..::..||.
  Fly    72 TFNYSISPPSRREKRHA----GHEHGPTSESRVP-----QITQYYLEKLM---AQDELMNSSGFD 124

Human    77 KLLQNIGIDKI------------KRIHIHH--DHDHHSDHEHHSDHERHSDHEHHSEHEHHSDHD 127
            .|||.:.:..:            .|: :||  .||||              |.|     ||.:.|
  Fly   125 GLLQQLSLHSLASGASEGTCVPGSRL-VHHVQPHDHH--------------HAH-----HHEEED 169

Human   128 HHSHHNHAASGKN--KRKALC---PDHDSDSSGKDPRNSQGKGAHRPEHASGRRNVKDSVSASEV 187
            |....|:....:|  ....:|   |::::...||:.:|.
  Fly   170 HSLQLNNCTLIQNGTTSNVICPSLPNNNTHPLGKEAKNF-------------------------- 208

Human   188 TSTVYNTVSEGTHFLETIETPRPGKLFPKDVSSSTPPSVTSKSRVSRLAGRKTNESVSEPRKGFM 252
                  |:|:                  ||:.
  Fly   209 ------TLSD------------------KDLL--------------------------------- 216

Human   253 YSRNTNENPQECFNASKLLTSHGMGIQVPLNATEFNYLCPAIINQIDARS--CL-------IHTS 308
                                                :|||.::.::.|:|  |:       |.|:
  Fly   217 ------------------------------------HLCPILLYELKAQSGGCIEPAILSDIDTT 245

Human   309 EKKAEIPPKTYSLQIAWVGGFIAISIISFLSLLGVILVPLMNRVFFKFLLSFLVALAVGTLSGDA 373
            |:..| ..|...:...|:..||::.....|.|:||.::|.|...::|:::.:||||||||::|||
  Fly   246 EELLE-AEKDKDIFYVWIYAFISVFACGILGLVGVAIIPFMGSRYYKYIIQYLVALAVGTMTGDA 309

Human   374 FLHLLPHSHASHHHSHSHEEPAMEMKRGPLFSHLSSQNIEESAYFDSTWKGLTALGGLYFMFLVE 438
            .|||||||.|      ..:|..|.|                        |||..|||:.|.:::|
  Fly   310 LLHLLPHSLA------GQDERGMIM------------------------KGLGCLGGIIFFYVME 344

Human   439 HVLTLIKQF-KDKKKKNQKKPE-----NDDDVEIKKQLS-------KYES------QLSTNEEKV 484
            |.||:|.:: |..:||..|||.     .|.|..:...::       ||.|      :::.|.::.
  Fly   345 HALTMISEWRKSVEKKETKKPSRAKVMRDPDSSVNNSVAGDKICKQKYSSYPYCYDEITMNNKQS 409

Human   485 D----TDDRTEGYLRADSQEPS----------HFDSQQPAVLEEEEVMIAHAHPQEVYNEYVPRG 535
            :    ..|...|   |....||          |..|...|...|.  :|:..|...|...:....
  Fly   410 EWMHLPFDVAAG---AGGDAPSVAELRNGVGDHDGSNDMAAAAES--LISPLHTNCVEMNHHNHN 469

Human   536 CKNKCHSHFHDTLGQSDDLI------------------HHHHDYHHILHHHHHQNHHPHSHSQRY 582
            .|:..|...|:  ||..:.|                  ...:|:..::...|..:||.|||  |:
  Fly   470 HKHNSHQQNHE--GQDSNTIVTDLDGNAVYAVNKAKDKDSRNDHVTVILREHESSHHGHSH--RH 530

Human   583 SREELKDAGVATLAWMVIMGDGLHNFSDGLAIGAAFTEGLSSGLSTSVAVFCHELPHELGDFAVL 647
            .........::.:|||:|||||||||:||:||||||.|.::.|.|||:|||||||||||||||:|
  Fly   531 GHVHSPPETLSAVAWMIIMGDGLHNFTDGMAIGAAFAENIAGGFSTSLAVFCHELPHELGDFAIL 595

Human   648 LKAGMTVKQAVLYNALSAMLAYLGMATGIFIGHYAENVSMWIFALTAGLFMYVALVDMVPEMLHN 712
            :||||:||.||.||.|:.:|:::||..||..|. :::|:.|:||:.||||:|:|||||:||:
  Fly   596 IKAGMSVKSAVYYNLLTGVLSFIGMIFGIAFGQ-SQDVAQWMFAVAAGLFIYIALVDMMPEI--- 656

Human   713 DASDHGCSRWGYFFLQNAGMLLGFGIMLLISIFE 746
             ::.|  ...|.|.||..|||.|.||||||:::|
  Fly   657 -SASH--KSLGQFLLQILGMLSGVGIMLLIALYE 687

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC39A6	NP_036451.4	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	95..186		17/95 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	202..246		2/43 (5%)
		Zip	323..742	CDD:396884	169/469 (36%)
foi	NP_523974.3	Zip	258..684	CDD:396884	170/471 (36%)