Protein Alignment GAK and Gak

DIOPT Version :10

• Sequence 1: XP_011511727.1
• Gene: GAK / 2580
• HGNCID: 4113
• Length: 1355
• Species: Homo sapiens
• Sequence 2: XP_063129735.1
• Gene: Gak / 81659
• RGDID: 621589
• Length: 1319
• Species: Rattus norvegicus
• Alignment Length: 1325
• Identity: 1051/1325 - (79%)
• Similarity: 1129/1325 - (85%)
• Gaps: 52/1325 - (3%)

Human     1 MSLLQSALDFLAGPGSLGGASGRDQSDFVGQTVELGELRLRVRRVLAEGGFAFVYEAQDVGSGRE 65
            ||||||||||||||||||||:||||||||||||||||||||||||||||||||||||||:|||||
  Rat     1 MSLLQSALDFLAGPGSLGGAAGRDQSDFVGQTVELGELRLRVRRVLAEGGFAFVYEAQDLGSGRE 65

Human    66 YALKRLLSNEEEKNRAIIQEVCFMKKLSGHPNIVQFCSAASIGKEESDTGQAEFLLLTELCKGQL 130
            |||||||||||||||||||||||:|||||||||||||||||||||||||||||||||||||||||
  Rat    66 YALKRLLSNEEEKNRAIIQEVCFLKKLSGHPNIVQFCSAASIGKEESDTGQAEFLLLTELCKGQL 130

Human   131 VEFLKKMESRGPLSCDTVLKIFYQTCRAVQHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSA 195
            ||||:::|.:||||||::|||||||||||||||||||||||||||||||||||||||||||||||
  Rat   131 VEFLRRVECKGPLSCDSILKIFYQTCRAVQHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSA 195

Human   196 TTISHYPDYSWSAQRRALVEEEITRNTTPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFRQ 260
            ||||||||||||||:||:||||||||||||||||||:||||||||||||||||||||||||||||
  Rat   196 TTISHYPDYSWSAQKRAMVEEEITRNTTPMYRTPEIVDLYSNFPIGEKQDIWALGCILYLLCFRQ 260

Human   261 HPFEDGAKLRIVNGKYSIPPHDTQYTVFHSLIRAMLQVNPEERLSIAEVVHQLQEIAAARNVNPK 325
            |||||||||||||||||||.:||:|||||.|||.||:|||||||||||||.||||||||||||||
  Rat   261 HPFEDGAKLRIVNGKYSIPVNDTRYTVFHDLIRGMLKVNPEERLSIAEVVRQLQEIAAARNVNPK 325

Human   326 SPITELLEQNGGYGSATLSRGPPPPVGPAGSGYSGGLALAEYDQPYGGFLDILRGGTERLFTNLK 390
            :|||||||||||||::..||..||..||..|  ||.|||||||||||||||||||||||||||||
  Rat   326 APITELLEQNGGYGNSGPSRAQPPSGGPVNS--SGVLALAEYDQPYGGFLDILRGGTERLFTNLK 388

Human   391 DTSSKVIQSVANYAKGDLDISYITSRIAVMSFPAEGVESALKNNIEDVRLFLDSKHPGHYAVYNL 455
            ||||||||||||||||||||||||||||||||||||||||:||||||||||||:|||||||||||
  Rat   389 DTSSKVIQSVANYAKGDLDISYITSRIAVMSFPAEGVESAIKNNIEDVRLFLDAKHPGHYAVYNL 453

Human   456 SPRTYRPSRFHNRVSECGWAARRAPHLHTLYNICRNMHAWLRQDHKNVCVVHCMDGRAASAVAVC 520
            |||.||.|:|||||:|||||.|||||||:||.:||:||||||:||:|||||||||||||||||||
  Rat   454 SPRIYRASKFHNRVTECGWAVRRAPHLHSLYTLCRSMHAWLREDHRNVCVVHCMDGRAASAVAVC 518

Human   521 SFLCFCRLFSTAEAAVYMFSMKRCPPGIWPSHKRYIEYMCDMVAEEPITPHSKPILVRAVVMTPV 585
            :|||||||||||||||||||||||||||||||||||||:|||||||||||||||:||::||||||
  Rat   519 AFLCFCRLFSTAEAAVYMFSMKRCPPGIWPSHKRYIEYVCDMVAEEPITPHSKPMLVKSVVMTPV 583

Human   586 PLFSKQRSGCRPFCEVYVGDERVASTSQEYDKMRDFKIEDGKAVIPLGVTVQGDVLIVIYHARST 650
            |||||||:|||||||||||:|||.:||||||:|::|||||||||||||:||||||||:|||||||
  Rat   584 PLFSKQRNGCRPFCEVYVGEERVTTTSQEYDRMKEFKIEDGKAVIPLGITVQGDVLIIIYHARST 648

Human   651 LGGRLQAKMASMKMFQIQFHTGFVPRNATTVKFAKYDLDACDIQEKYPDLFQVNLEVEVEPRDRP 715
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   649 LGGRLQAKMASMKMFQIQFHTGFVPRNATTVKFAKYDLDACDIQEKYPDLFQVNLEVEVEPRDRP 713

Human   716 SREAPPWENSSMRGLNPKILFSSREEQQDILSKFGKPELPRQPGSTAQYDAGAGSPEAEPTDSDS 780
            ||:.|||||:|:||||||||||:||||||||||||||||||||||||||||.|||||||.|:|||
  Rat   714 SRDVPPWENTSLRGLNPKILFSNREEQQDILSKFGKPELPRQPGSTAQYDAEAGSPEAEITESDS 778

Human   781 PPSSSADASRFLHTLDWQEEKEAETGAENASSKESESALMEDRDESEVSDEGGSPISSEGQEPRA 845
            |.|||.|.:.|||||||||||:.|||.:|.|.|||:|.|:.|.|.||||||..:...||.::|.|
  Rat   779 PQSSSTDTNHFLHTLDWQEEKDPETGVDNTSPKESQSNLIADGDGSEVSDEEEASCPSEERKPGA 843

Human   846 DPEPPGLAAGLVQQDLVFEVETPAVLPEPVPQEDGVDLLGLHSEVGAGPAVPPQACKAPSSNTDL 910
            ..:.|.||||..||||:|:|...|...|||..|:||||||||||....||.|.||....||||||
  Rat   844 GEDTPRLAAGTRQQDLIFDVGMLAAPQEPVQPEEGVDLLGLHSEGDLRPAAPLQASGVQSSNTDL 908

Human   911 LSCLLGPPEAASQGPPEDLL-SEDPLLLASPAPPLSVQSTPRGGPPAAADPFGPLLPSSGNNSQP 974
            ||.||.|.:|:..|||.||| .|.|||||||...|.|||..:|..|...|||...|..|.:::||
  Rat   909 LSSLLEPSDASQVGPPGDLLGGETPLLLASPVSLLGVQSNLQGKVPDTVDPFDQFLLPSSSDTQP 973

Human   975 CSNPDLFGEFLNSDSVTVPPSFPSAHSAPPPSCSADFLHLGDLPGEPSKMTASSSNPDLLGGWAA 1039
            ||.|||||||||||||....:|||.|||||||||..||||||||.||:|:.||||:|||||||..
  Rat   974 CSKPDLFGEFLNSDSVASSTAFPSTHSAPPPSCSTAFLHLGDLPAEPNKVIASSSHPDLLGGWDT 1038

Human  1040 WTETAASAVAPTPATEGPLFSPGGQPAPCGSQASWTKSQNPDPFADLGDLSSGLQDPQAQSTVSP 1104
            |.|||....|..|..||.|||..|.|||.|...|.||||||||||||.||||.||
  Rat  1039 WAETALPGPASMPVPEGTLFSSAGHPAPPGPNPSQTKSQNPDPFADLSDLSSSLQ---------- 1093

Human  1105 RGQRVCTCSRRLPTGKLKPGVADTGTAASPHRHCGSPAGFPPGGFIPKTATTPKGSSSWQTSRPP 1169
                                              |.|||.|.|.|:..:|||.|.:|||||:||.
  Rat  1094 ----------------------------------GLPAGLPAGSFVGTSATTHKSNSSWQTTRPT 1124

Human  1170 AQGASWPPQAKPPPKACTQPRPNYASNFSVIGAREERGVRAPSFAQKPKVSENDFEDLLSNQGFS 1234
            |.|.||||||||.|:|..|.|    |:||||||||||||||||||||||||||||||||.||||
  Rat  1125 APGTSWPPQAKPAPRASEQLR----SHFSVIGAREERGVRAPSFAQKPKVSENDFEDLLPNQGF- 1184

Human  1235 SRSDKKGPKTIAEMRKQDLAKDTDPLKLKLLDWIEGKERNIRALLSTLHTVLWDGESRWTPVGMA 1299
            |:||||||||:||||||:||:||||.||||||||||||||||||||||||||||||||||||.||
  Rat  1185 SKSDKKGPKTMAEMRKQELARDTDPFKLKLLDWIEGKERNIRALLSTLHTVLWDGESRWTPVSMA 1249

Human  1300 DLVAPEQVKKHYRRAVLAVHPDKAA 1324
            |||.||||||.||||||.|||||.:
  Rat  1250 DLVTPEQVKKQYRRAVLVVHPDKVS 1274

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GAK	XP_011511727.1	STKc_GAK	39..320	CDD:270938	261/280 (93%)
		PTP_GAK	400..562	CDD:350412	146/161 (91%)
		PTEN_C2	570..708	CDD:463081	125/137 (91%)
		PHA03247	<839..1169	CDD:223021	174/330 (53%)
		DnaJ	<1304..1348	CDD:99751	17/21 (81%)
Gak	XP_063129735.1	None