Protein Alignment GAK and gak

DIOPT Version :10

• Sequence 1: XP_011511727.1
• Gene: GAK / 2580
• HGNCID: 4113
• Length: 1355
• Species: Homo sapiens
• Sequence 2: NP_001016350.2
• Gene: gak / 549104
• XenbaseID: XB-GENE-5893404
• Length: 1322
• Species: Xenopus tropicalis
• Alignment Length: 1398
• Identity: 918/1398 - (65%)
• Similarity: 1054/1398 - (75%)
• Gaps: 119/1398 - (8%)

Human     1 MSLLQSALDFLAGPGSLGGASGRDQSDFVGQTVELGELRLRVRRVLAEGGFAFVYEAQDVGSGRE 65
            |||||||||||||||||||| ||||.||||||||:|::::||:||:|||||||||||||||||::
 Frog     1 MSLLQSALDFLAGPGSLGGA-GRDQHDFVGQTVEMGDMKMRVKRVIAEGGFAFVYEAQDVGSGKD 64

Human    66 YALKRLLSNEEEKNRAIIQEVCFMKKLSGHPNIVQFCSAASIGKEESDTGQAEFLLLTELCKGQL 130
            ||||||||||||||::||||:||||||||||||||||||||||||||||||.|||||||||:|||
 Frog    65 YALKRLLSNEEEKNKSIIQEICFMKKLSGHPNIVQFCSAASIGKEESDTGQGEFLLLTELCRGQL 129

Human   131 VEFLKKMESRGPLSCDTVLKIFYQTCRAVQHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSA 195
            ||||.|.|.:|||||||||||||||||||||||:||||||||||||||||:|||||:|||||||:
 Frog   130 VEFLNKAECKGPLSCDTVLKIFYQTCRAVQHMHKQKPPIIHRDLKVENLLVSNQGTVKLCDFGSS 194

Human   196 TTISHYPDYSWSAQRRALVEEEITRNTTPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFRQ 260
            |||:|||||:|:||:||.||:|:||||||||||||||||||||||||||||||||||||||||:|
 Frog   195 TTIAHYPDYNWTAQQRATVEDEVTRNTTPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFKQ 259

Human   261 HPFEDGAKLRIVNGKYSIPPHDTQYTVFHSLIRAMLQVNPEERLSIAEVVHQLQEIAAARNVNPK 325
            |||||||||||||||||:|.:||:|||||.||.:|::|||||||||.|||.||||||||||||||
 Frog   260 HPFEDGAKLRIVNGKYSVPQNDTKYTVFHGLINSMIKVNPEERLSITEVVSQLQEIAAARNVNPK 324

Human   326 SPITELLEQNGGYGSATLSR---GPPPPVGPAGSGYSGGLALAEYDQPYGGFLDILRGGTERLFT 387
            ||||||||||||||:..:.|   |.|....|..   ..||.|.:.||..|||.|||:|||||:.:
 Frog   325 SPITELLEQNGGYGNTVIQRSSSGAPQNSKPLA---HPGLTLTDDDQTSGGFFDILKGGTERILS 386

Human   388 NLKDTSSKVIQSVANYAKGDLDISYITSRIAVMSFPAEGVESALKNNIEDVRLFLDSKHPGHYAV 452
            |:|||||||||||.||||||||:||||||||||||||||||||:|||||||||||||||||||||
 Frog   387 NIKDTSSKVIQSVTNYAKGDLDLSYITSRIAVMSFPAEGVESAIKNNIEDVRLFLDSKHPGHYAV 451

Human   453 YNLSPRTYRPSRFHNRVSECGWAARRAPHLHTLYNICRNMHAWLRQDHKNVCVVHCMDGRAASAV 517
            |||..|.||||:|||||||||||.||||:|..||:||:|||.||:||.||||:|||.||||||||
 Frog   452 YNLCLRKYRPSKFHNRVSECGWAGRRAPNLMNLYSICKNMHLWLKQDPKNVCIVHCTDGRAASAV 516

Human   518 AVCSFLCFCRLFSTAEAAVYMFSMKRCPPGIWPSHKRYIEYMCDMVAEEPITPHSKPILVRAVVM 582
            .:||||||||||:||||||||||||||||||||||||||||||||:|||||.|||||||:||:.|
 Frog   517 VLCSFLCFCRLFTTAEAAVYMFSMKRCPPGIWPSHKRYIEYMCDMMAEEPIIPHSKPILIRAITM 581

Human   583 TPVPLFSKQRSGCRPFCEVYVGDERVASTSQEYDKMRDFKIEDGKAVIPLGVTVQGDVLIVIYHA 647
            ||||||||||:||||||||||||||||:|||||||||||:.|||||.|||.||||||||||||||
 Frog   582 TPVPLFSKQRNGCRPFCEVYVGDERVATTSQEYDKMRDFRNEDGKAEIPLNVTVQGDVLIVIYHA 646

Human   648 RSTLGGRLQAKMASMKMFQIQFHTGFVPRNATTVKFAKYDLDACDIQEKYPDLFQVNLEVEVEPR 712
            ||||||||||||.|||||||||||||||||||||||||||||||||||||||||||||||||..|
 Frog   647 RSTLGGRLQAKMTSMKMFQIQFHTGFVPRNATTVKFAKYDLDACDIQEKYPDLFQVNLEVEVSSR 711

Human   713 DRPSREAPPWENSSMRGLNPKILFSSREEQQDILSKFGKPELPRQPGSTAQYDAGAGSPEAEPTD 777
            |:.:..:|||||.:.:.||||||||||||||::|||||||||||||||||||:......:..|..
 Frog   712 DKQATSSPPWENINTKRLNPKILFSSREEQQEMLSKFGKPELPRQPGSTAQYEGDINMEKPSPDL 776

Human   778 SDSPPSSSADASRFLHTLDWQEE---KEAETG-AENASSKESESALMEDRDESEVSDE------- 831
            ||   |.:...:.|..|||||::   :.|:.| .||.:.::.|:..:.| .:||.|||
 Frog   777 SD---SETLQKNNFFQTLDWQDQSGVRNAQIGDQENVAKEDYENEYLSD-SKSEASDEEFYSFPQ 837

Human   832 GGSPISSEGQEPRADPEPPGLAAGLVQQDLVFEV--ETPAVLPEPVPQEDGVDLLGLHSEVGAGP 894
            |...|..|...|....:..      |.::::||.  :|.:....| |.|:.||||||:      |
 Frog   838 GNRGIRCEENGPAVGTDDS------VAREVLFEANKDTQSTEQGP-PVEEEVDLLGLN------P 889

Human   895 A-------VPPQACKAPSSNTDLLSCLLGPP-EAASQGPPEDLLSEDPLLLASPA-------PPL 944
            |       ..|...|..|||..||..|.... ...:.....|.:..|  ||.:..       |..
 Frog   890 ATNKVDTNTVPSEIKNSSSNIALLDNLFSDSLSGTADNVKTDFIGHD--LLGNRGDFYFIGPPQT 952

Human   945 SVQSTPRGG--PPAAADPFGPLLPSSGNNSQPCSNPDLFGEFLNSDSVTVPPSFPSAHSAPPPSC 1007
            ||:|:....  |.:::|||.|...|:..|..  |.||||...::.:|.:.|..:||..||.||:.
 Frog   953 SVESSSNSFDIPFSSSDPFDPFAMSTSENKS--SGPDLFEGLVSPNSASTPNVYPSVQSAAPPTS 1015

Human  1008 SADFLHLGDLPGEPSKMTASSSNPDLLGGWAAWTETAASA--VAP---TPATEGPLFSPGGQPAP 1067
            :.|||:|.:||...||:.:|:|||||||||::|.||:.|:  ..|   .||.|||.:|.....:.
 Frog  1016 NIDFLNLDNLPTRQSKIVSSASNPDLLGGWSSWEETSKSSNVFLPKLNKPAFEGPAYSSTSHLST 1080

Human  1068 CGSQA-SWTKSQNPDPFADLGDLSSGLQDPQAQSTVSPRGQRVCTCSRRLPTGKLKPGVADTGTA 1131
            ..|.: |.|||...||||||.:|||.||
 Frog  1081 SSSSSFSQTKSSGFDPFADLDNLSSSLQ------------------------------------- 1108

Human  1132 ASPHRHCGSPAGFPPGGFIPKTATTPKGSSSWQTSRPPAQ----GASWPPQAKPPPKACTQPRPN 1192
                   ||...||... ..|:|  .|.|:|||:.:.||:    |..|..||||    .||.:||
 Frog  1109 -------GSSTQFPSQS-TEKSA--QKVSNSWQSVKQPAKPQTGGNPWQSQAKP----ATQSKPN 1159

Human  1193 YASNFSVIGAREERGVRAPSFAQKPKVSENDFEDLLSNQGFSSRSDKKGPKTIAEMRKQDLAKDT 1257
            |.:||||||.|||||:|||.|..||||||:||.|||||.|||:::|:.|||||||||:.:|.|||
 Frog  1160 YTANFSVIGGREERGIRAPGFGLKPKVSESDFGDLLSNHGFSAKTDRGGPKTIAEMRRHELTKDT 1224

Human  1258 DPLKLKLLDWIEGKERNIRALLSTLHTVLWDGESRWTPVGMADLVAPEQVKKHYRRAVLAVHPDK 1322
            ||||||:||||||||||||||:||||||||:|||||.||.||:||.|:||||:||:|||.|||||
 Frog  1225 DPLKLKILDWIEGKERNIRALISTLHTVLWEGESRWKPVNMAELVTPDQVKKYYRKAVLVVHPDK 1289

Human  1323 AAGQPYEQHAKMIFMELNDAWSEFENQGSRPLF 1355
            |.||||||:|||||||||||||||||||||.||
 Frog  1290 ATGQPYEQYAKMIFMELNDAWSEFENQGSRSLF 1322

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GAK	XP_011511727.1	STKc_GAK	39..320	CDD:270938	242/280 (86%)
		PTP_GAK	400..562	CDD:350412	140/161 (87%)
		PTEN_C2	570..708	CDD:463081	127/137 (93%)
		PHA03247	<839..1169	CDD:223021	109/354 (31%)
		DnaJ	<1304..1348	CDD:99751	37/43 (86%)
gak	NP_001016350.2	STKc_GAK	38..319	CDD:270938	242/280 (86%)
		PTP_GAK	399..561	CDD:350412	140/161 (87%)
		PTEN_C2	569..707	CDD:463081	127/137 (93%)
		DnaJ	<1270..1315	CDD:99751	37/44 (84%)