Protein Alignment GAK and Pten

DIOPT Version :10

• Sequence 1: XP_011511727.1
• Gene: GAK / 2580
• HGNCID: 4113
• Length: 1355
• Species: Homo sapiens
• Sequence 2: NP_477422.2
• Gene: Pten / 43991
• FlyBaseID: FBgn0026379
• Length: 514
• Species: Drosophila melanogaster
• Alignment Length: 464
• Identity: 110/464 - (23%)
• Similarity: 199/464 - (42%)
• Gaps: 100/464 - (21%)

Human   394 SKVIQSVAN------YAKG-DLDISYITSRIAVMSFPA-EGVESALKNNIEDVRLFLDSKHPGHY 450
            |.||::|.:      ..|| |||::||...|..|.:|| :.:|...:|.:|||...|:..|..||
  Fly     9 SNVIRNVVSKKRIRYKEKGYDLDLTYINDNIIAMGYPAPDKLEGLFRNRLEDVFKLLEENHAQHY 73

Human   451 AVYNL-SPRTYRPSRFHNRVSECGWAARRAPHLHTLYNICRNMHAWLRQDHKNVCVVHCMDGRAA 514
            .:||| |.|:|..::|..||:...:.....|.:..:...|.::..||::|..||..|||..|:..
  Fly    74 KIYNLCSERSYDVAKFRGRVAVYPFDDHNPPTIELIQRFCSDVDMWLKEDSSNVVAVHCKAGKGR 138

Human   515 SAVAVCSFLCFCRLFSTAEAAVYMFSMKRCP--PGIW-PSHKRYIEYMCDMVAEEPITPHSKPIL 576
            :...:|::|.|..:..:|:.|:..:..||..  .|:. ||.:||::|...:|...  .|:||..|
  Fly   139 TGTMICAYLVFSGIKKSADEALAWYDEKRTKDRKGVTIPSQRRYVQYFSKLVCSS--VPYSKVSL 201

Human   577 ----VRAVVMTPVPLFSKQRSGC-----RPFCEVYVGDERVASTSQEYDKMRDFKIEDGKA---V 629
                :|         ||:  |.|     ...|.:.|..:. |:.:.:.|:::...|:..|:   .
  Fly   202 NVCEIR---------FSE--SSCVQNLGMVECSISVLHDS-ATENAKPDRLKTLPIDFQKSFVLT 254

Human   630 IPLGVTVQGDVLIVIYHARSTLGGRLQAKMASMKMFQIQFHTGFVPRN-------ATTVKF---- 683
            |...:.|.|||..           .|..|.....:.....:|.|| ||       .|..|:
  Fly   255 IKPSIPVSGDVKF-----------ELTKKSPDKIICHFWLNTFFV-RNYSPCESDGTVNKYIHTL 307

Human   684 AKYDLDACDI-----QEKYPDLFQVNLEVEVEPRDRPSREAPPWENSSMRGLNPKILFSSREEQQ 743
            :|.::|  |:     .:::.:.|::::..|.             ||.|    |.....:|.:|:.
  Fly   308 SKSEID--DVHKDSEHKRFSEEFKISIVFEA-------------ENFS----NDVQAEASEKERN 353

Human   744 DILSKFGKPELPRQPGSTAQYDAGAGSPEAEPTDSDSPPSSSADASRFLHTLDWQE-----EKEA 803
            :.:..|.:          :.||:.:.:..||.....:..:.:...|:.:.|||.::     :.:.
  Fly   354 ENVLNFER----------SDYDSLSPNCYAEKKVLTAIVNDNTTKSQTIETLDHKDIVTKIQYDT 408

Human   804 ETGAENASS 812
            .|.::|.|:
  Fly   409 STNSKNTST 417

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GAK	XP_011511727.1	STKc_GAK	39..320	CDD:270938
		PTP_GAK	400..562	CDD:350412	54/173 (31%)
		PTEN_C2	570..708	CDD:463081	33/165 (20%)
		PHA03247	<839..1169	CDD:223021
		DnaJ	<1304..1348	CDD:99751
Pten	NP_477422.2	PTP_PTEN	31..189	CDD:350359	49/157 (31%)
		PTEN_C2	196..335	CDD:463081	32/164 (20%)