Protein Alignment GAK and CG1227

DIOPT Version :10

• Sequence 1: XP_011511727.1
• Gene: GAK / 2580
• HGNCID: 4113
• Length: 1355
• Species: Homo sapiens
• Sequence 2: NP_649712.1
• Gene: CG1227 / 40872
• FlyBaseID: FBgn0037491
• Length: 320
• Species: Drosophila melanogaster
• Alignment Length: 297
• Identity: 82/297 - (27%)
• Similarity: 147/297 - (49%)
• Gaps: 19/297 - (6%)

Human    31 QTVELGELRLRVRRVLAEGGFAFVYEAQDVGSGREYALKRLLSNEEEKNRAIIQEVCFMKKLSGH 95
            :|:.:...|..:|..||.|||:.:...::..:.|.||:||:..:..:.....::|:...:|:...
  Fly    21 ETLNINGSRYTIRERLATGGFSLIDLGENASTRRSYAIKRITCHSIDDQNIALREIENCRKIDSE 85

Human    96 PNIVQFCSAASIGKEE--SDTGQAEFLLLTELCKGQLVEFLK-KMESRGPLSCDTVLKIFYQTCR 157
             |:::.......|:.:  .:|....|::|.....|.|.:.|: :...:..:....:|:||...|.
  Fly    86 -NVIRVVDYELKGQADIVINTTSTLFIVLPYYKHGSLADHLQLRSRKQDHMPEAQILQIFLGVCE 149

Human   158 AVQHMHRQKP-PIIHRDLKVENLLLSNQGTIKLCDFGSATTISHYPDYSWSAQRRALVEEEITRN 221
            .::.:|...| |:.|||||..|:.||:.....:.|.||.|...........|||   :::|....
  Fly   150 GLKAIHEAMPVPLAHRDLKTANICLSDSFEPIIVDLGSMTEARLQIVGQTDAQR---LQDEAEER 211

Human   222 TTPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFRQHPFE------DGAKLRIVNGKYSIPP 280
            ::.:||.||:..:.:...|.|:.|||:|||:||.:|:...|::      |...|.:::|..:| |
  Fly   212 SSIVYRAPELFTVKTYCTIDERTDIWSLGCVLYAMCYFNSPYDPIYERGDSVALAVLSGNINI-P 275

Human   281 HDTQYTV-FHSLIRAMLQVNPEER---LSIAEVVHQL 313
            .|:.||. .|.||:.||:.:|.||   .|:.|..|.|
  Fly   276 EDSIYTEDMHELIKYMLRTDPMERPFVFSVIERTHDL 312

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GAK	XP_011511727.1	STKc_GAK	39..320	CDD:270938	81/289 (28%)
		PTP_GAK	400..562	CDD:350412
		PTEN_C2	570..708	CDD:463081
		PHA03247	<839..1169	CDD:223021
		DnaJ	<1304..1348	CDD:99751
CG1227	NP_649712.1	STKc_16	29..314	CDD:270888	81/289 (28%)