Protein Alignment GAK and aux

DIOPT Version :10

• Sequence 1: XP_011511727.1
• Gene: GAK / 2580
• HGNCID: 4113
• Length: 1355
• Species: Homo sapiens
• Sequence 2: NP_649438.1
• Gene: aux / 40527
• FlyBaseID: FBgn0037218
• Length: 1165
• Species: Drosophila melanogaster
• Alignment Length: 1375
• Identity: 491/1375 - (35%)
• Similarity: 681/1375 - (49%)
• Gaps: 259/1375 - (18%)

Human     6 SALDFLAGPGSLGGASGRDQSDFVGQTVELGELRLRVRRVLAEGGFAFVYEAQDVGSGREYALKR 70
            |.::..||.|:.....||..:|||||.||:...|||::.|:||||:||||.||||.:|.||||||
  Fly    16 SEVNGAAGNGAPEALGGRLDNDFVGQVVEVAGHRLRIKCVIAEGGYAFVYVAQDVQTGTEYALKR 80

Human    71 LLSNEEEKNRAIIQEVCFMKKLSGHPNIVQFCSAASIGKEESDTGQAEFLLLTELCK-GQLVEFL 134
            |:..:.:.:.|||.|:...|:||||.|||.|. .:|.....:..| |::|||||||| |.||:..
  Fly    81 LIGADMQASTAIINEINIHKQLSGHENIVAFV-GSSYTAPSTQLG-AQYLLLTELCKGGSLVDCF 143

Human   135 KKMESRGPLSCDTVLKIFYQTCRAVQHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTIS 199
            :  .:..|.:...||:||||..|||..:|.|.|||.|||:|:||.|:.|...|||||||||:|..
  Fly   144 R--TNNAPFNPTCVLRIFYQMARAVASLHSQSPPIAHRDIKIENFLIGNDKQIKLCDFGSASTEV 206

Human   200 HYPDYSWSAQRRALVEEEITRNTTPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFRQHPFE 264
            ..|.:.|||.:|:::|:::...||||||:||::|.:||.|||.|.||||||||||.||:|:||:|
  Fly   207 LSPTFEWSANQRSMLEDQLNTVTTPMYRSPEMLDTWSNNPIGPKVDIWALGCILYFLCYRKHPYE 271

Human   265 DGAKLRIVNGKYSIPPHDTQYTVFHSLIRAMLQVNPEERLSIAEVVHQLQEIAAARNVNPKSPI- 328
            ||.||||:|..|.:|| |.||..|..:||..|:|||.|||.|..|:..|..:|...|.:.|.|:
  Fly   272 DGGKLRIINANYMLPP-DPQYQCFSDIIRGCLKVNPFERLDITMVLEGLAALAETHNWSLKGPLD 335

Human   329 -----TELLEQNGGYGSATLSRGPPPPVGPA-GSGYSGGLALAEYDQPYGGFLDILRGGTERLFT 387
                 .|.|.......|:..|.....|:..| .|.|:|          :|..|..||||...|..
  Fly   336 LHIMPIESLPAESPLKSSAYSEVYTEPLSAAIPSSYNG----------HGSLLSSLRGGAGTLLK 390

Human   388 NLKDTSSKVIQSV-ANYAKGDLDISYITSRIAVMSFPAEGVESALK-NNIEDVRLFLDSKH-PGH 449
            |:||||:||:|:: .:.|:.|||||:|||||.||..|::|.||..| ||||||||.|:|:. |..
  Fly   391 NIKDTSTKVMQTMQQSLARNDLDISHITSRILVMPCPSDGFESTYKTNNIEDVRLSLESRFVPQK 455

Human   450 YAVYNL----SPRTYRPSRFHNRVSECGWAARRAPHLHTLYNICRNMHAWLRQDHKNVCVVHCMD 510
            .::||.    .||...|.|.....|..|.....||:|..|:.:..:|:.:|..|.|:|.:|...|
  Fly   456 LSIYNFGQRTEPRLPPPVRTVEAGSVYGCPQAHAPNLQGLFTVSADMYNFLNADPKSVVIVQTGD 520

Human   511 -GRAASAVAVCSFLCFCRLFSTAEAAVYMFSMKRCPPGIWPSHKRYIEYMCDMVAEEPITPHSKP 574
             |...:|..:|:.|.:..|....|.||.:|::||....:.||..||:.|..|::...|:.||.|.
  Fly   521 SGGCTAATVICALLMYADLLREPEDAVQVFAVKRHTINLRPSEFRYLYYFGDILRPTPLLPHYKN 585

Human   575 ILVRAVVMTPVPLFSKQRSGCRPFCEVYVGDERVASTSQEYDKMRDFKIEDGKAVIPLGVTVQGD 639
            ..:.::...|||..:|.|.|||.:.|||.....:.||.|:|:|||.::...||.|:|:.:|..||
  Fly   586 TTLVSLSCQPVPRMTKARDGCRIYMEVYCNGNLLLSTLQDYEKMRLYQAGPGKIVLPINLTACGD 650

Human   640 VLIVIYHARSTLGGRLQAKMASMKMFQIQFHTGFVPRNATTVKFAKYDLDACDIQEKYPDLFQVN 704
            |.:|::|||..:     .:...:|:.|.||:|||:|...|.:.|...|||.....|:....|.|:
  Fly   651 VTVVLFHARKGM-----VRPQGLKICQFQFNTGFIPEPETLITFTNQDLDDLPDPEQVTPRFCVS 710

Human   705 LEVEVEPRDRPSREAPPWENSSMRGLNPKILFSSREEQQDILSKFGKPELPRQPGSTAQYDAGAG 769
            |.:.|...:.|....|||..:..: .:|..||||..|..::|..|
  Fly   711 LSLAVTDSESPPSHKPPWMPAKPK-RSPAALFSSDLEYAEMLDNF-------------------- 754

Human   770 SPEAEPTDSDSPPSSSADASRFLHTLDWQEEKEAETGAENASSKESESALMEDRDESEVSDEGGS 834
              ..:|:...|||                      .||..                   ||...|
  Fly   755 --VTKPSTRSSPP----------------------PGARK-------------------SDRVSS 776

Human   835 PISSEGQEPRADPEPPGLAAGLVQQDLVFEV-ETPAVLPEPVPQEDGVDLLGLHSEVGAGPAVPP 898
            |                    ||..|:.... |.|:.:|||.|.   :|||.|:.:....||..|
  Fly   777 P--------------------LVLPDVTETAHELPSPMPEPSPP---IDLLNLNQQPSDVPAADP 818

Human   899 QACKAPSSNT--DLLSCLLGPPEAASQG--PPEDLLSEDPLLLASPAPPLSVQSTPRGGPPAAAD 959
            .....||::.  |||.. .|..::...|  |..|:|         |.|||   ..|:  |....|
  Fly   819 LTSAKPSTDASFDLLGA-FGDDDSTGIGSAPIPDIL---------PPPPL---QQPQ--PKINND 868

Human   960 PFGPLLPSSGNNSQPCSNPDLFGEFLNSDSVTVPPSFPSAHSAPPPSCSADFLHLGDLP---GEP 1021
            ||                 |:||   :.|...||...||..   ||       .:|.||   .:|
  Fly   869 PF-----------------DIFG---SVDQGGVPSMKPSGF---PP-------FVGSLPTFVAQP 903

Human  1022 SKMTASSSNPDLLGGWAAWTETAASAVAPTPATEGPLFSPGGQPAPCGSQASWTKSQNPDPFADL 1086
                |:::||                 :||            .||...:          ||||::
  Fly   904 ----AATTNP-----------------SPT------------HPARASA----------DPFANI 925

Human  1087 GDLSSGLQDPQAQSTVSPRGQRVCTCSRRLPTGKLKPGVADTGTAASPHRHCGSPAGFPPGGFIP 1151
            .||::||.....:||:|               ||.....:...|..|...|..||:..|...|:
  Fly   926 ADLATGLNLNFNRSTLS---------------GKSPVNTSPQPTQFSSPTHKPSPSSQPQATFM- 974

Human  1152 KTATTPKGSSSWQTSRPPAQGASWPPQAKPPPKACTQPRPNYAS-NFSVIGAREERGVRAPSFAQ 1215
            .|..||:...|..:.|.|.|     |||.|     .|.||:|:. :|....|.::.|...
  Fly   975 HTPPTPQTLPSTSSIRTPTQ-----PQAVP-----AQSRPDYSRLHFDSQKAAQQPGTGG----- 1024

Human  1216 KPKVSEND--FEDLLSNQGFSSRSD-KKGPKTIAEMRKQDLAKDTDPLKLKLLDWIEGKERNIRA 1277
                |:|.  |.|:|..||:|..|. .:.|::|.||||:||.||.||.|:::::|.:||:.||||
  Fly  1025 ----SKNSDIFADILGQQGYSFGSKMNQCPRSINEMRKEDLFKDMDPKKVRIMEWTDGKKNNIRA 1085

Human  1278 LLSTLHTVLWDGESRWTPVGMADLVAPEQVKKHYRRAVLAVHPDKAAGQPYEQHAKMIFMELNDA 1342
            ||.::|||||| .::|....|:.:|.|.:|||.||||.|||||||..|...|:.||:||||||:|
  Fly  1086 LLCSMHTVLWD-NAKWQRCEMSTMVTPTEVKKAYRRACLAVHPDKHNGTENEEIAKLIFMELNNA 1149

Human  1343 WSEFENQGSR 1352
            |::|||..::
  Fly  1150 WTDFENDATQ 1159

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GAK	XP_011511727.1	STKc_GAK	39..320	CDD:270938	148/281 (53%)
		PTP_GAK	400..562	CDD:350412	64/169 (38%)
		PTEN_C2	570..708	CDD:463081	50/137 (36%)
		PHA03247	<839..1169	CDD:223021	81/337 (24%)
		DnaJ	<1304..1348	CDD:99751	28/43 (65%)
aux	NP_649438.1	Protein Kinases, catalytic domain	49..326	CDD:473864	148/281 (53%)
		PTP_auxilin-like	404..573	CDD:350361	64/168 (38%)
		PTEN_C2	581..711	CDD:463081	49/134 (37%)
		PHA03247	<698..1037	CDD:223021	126/548 (23%)
		Herpes_BLLF1	<882..>999	CDD:282904	46/190 (24%)
		DnaJ	<1110..1150	CDD:99751	25/39 (64%)