DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment GAK and aux

DIOPT Version :9

Sequence 1:XP_011511727.1 Gene:GAK / 2580 HGNCID:4113 Length:1355 Species:Homo sapiens
Sequence 2:NP_649438.1 Gene:aux / 40527 FlyBaseID:FBgn0037218 Length:1165 Species:Drosophila melanogaster


Alignment Length:1375 Identity:491/1375 - (35%)
Similarity:681/1375 - (49%) Gaps:259/1375 - (18%)


- Green bases have known domain annotations that are detailed below.


Human     6 SALDFLAGPGSLGGASGRDQSDFVGQTVELGELRLRVRRVLAEGGFAFVYEAQDVGSGREYALKR 70
            |.::..||.|:.....||..:|||||.||:...|||::.|:||||:||||.||||.:|.||||||
  Fly    16 SEVNGAAGNGAPEALGGRLDNDFVGQVVEVAGHRLRIKCVIAEGGYAFVYVAQDVQTGTEYALKR 80

Human    71 LLSNEEEKNRAIIQEVCFMKKLSGHPNIVQFCSAASIGKEESDTGQAEFLLLTELCK-GQLVEFL 134
            |:..:.:.:.|||.|:...|:||||.|||.|. .:|.....:..| |::|||||||| |.||:..
  Fly    81 LIGADMQASTAIINEINIHKQLSGHENIVAFV-GSSYTAPSTQLG-AQYLLLTELCKGGSLVDCF 143

Human   135 KKMESRGPLSCDTVLKIFYQTCRAVQHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTIS 199
            :  .:..|.:...||:||||..|||..:|.|.|||.|||:|:||.|:.|...|||||||||:|..
  Fly   144 R--TNNAPFNPTCVLRIFYQMARAVASLHSQSPPIAHRDIKIENFLIGNDKQIKLCDFGSASTEV 206

Human   200 HYPDYSWSAQRRALVEEEITRNTTPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFRQHPFE 264
            ..|.:.|||.:|:::|:::...||||||:||::|.:||.|||.|.||||||||||.||:|:||:|
  Fly   207 LSPTFEWSANQRSMLEDQLNTVTTPMYRSPEMLDTWSNNPIGPKVDIWALGCILYFLCYRKHPYE 271

Human   265 DGAKLRIVNGKYSIPPHDTQYTVFHSLIRAMLQVNPEERLSIAEVVHQLQEIAAARNVNPKSPI- 328
            ||.||||:|..|.:|| |.||..|..:||..|:|||.|||.|..|:..|..:|...|.:.|.|: 
  Fly   272 DGGKLRIINANYMLPP-DPQYQCFSDIIRGCLKVNPFERLDITMVLEGLAALAETHNWSLKGPLD 335

Human   329 -----TELLEQNGGYGSATLSRGPPPPVGPA-GSGYSGGLALAEYDQPYGGFLDILRGGTERLFT 387
                 .|.|.......|:..|.....|:..| .|.|:|          :|..|..||||...|..
  Fly   336 LHIMPIESLPAESPLKSSAYSEVYTEPLSAAIPSSYNG----------HGSLLSSLRGGAGTLLK 390

Human   388 NLKDTSSKVIQSV-ANYAKGDLDISYITSRIAVMSFPAEGVESALK-NNIEDVRLFLDSKH-PGH 449
            |:||||:||:|:: .:.|:.|||||:|||||.||..|::|.||..| ||||||||.|:|:. |..
  Fly   391 NIKDTSTKVMQTMQQSLARNDLDISHITSRILVMPCPSDGFESTYKTNNIEDVRLSLESRFVPQK 455

Human   450 YAVYNL----SPRTYRPSRFHNRVSECGWAARRAPHLHTLYNICRNMHAWLRQDHKNVCVVHCMD 510
            .::||.    .||...|.|.....|..|.....||:|..|:.:..:|:.:|..|.|:|.:|...|
  Fly   456 LSIYNFGQRTEPRLPPPVRTVEAGSVYGCPQAHAPNLQGLFTVSADMYNFLNADPKSVVIVQTGD 520

Human   511 -GRAASAVAVCSFLCFCRLFSTAEAAVYMFSMKRCPPGIWPSHKRYIEYMCDMVAEEPITPHSKP 574
             |...:|..:|:.|.:..|....|.||.:|::||....:.||..||:.|..|::...|:.||.|.
  Fly   521 SGGCTAATVICALLMYADLLREPEDAVQVFAVKRHTINLRPSEFRYLYYFGDILRPTPLLPHYKN 585

Human   575 ILVRAVVMTPVPLFSKQRSGCRPFCEVYVGDERVASTSQEYDKMRDFKIEDGKAVIPLGVTVQGD 639
            ..:.::...|||..:|.|.|||.:.|||.....:.||.|:|:|||.::...||.|:|:.:|..||
  Fly   586 TTLVSLSCQPVPRMTKARDGCRIYMEVYCNGNLLLSTLQDYEKMRLYQAGPGKIVLPINLTACGD 650

Human   640 VLIVIYHARSTLGGRLQAKMASMKMFQIQFHTGFVPRNATTVKFAKYDLDACDIQEKYPDLFQVN 704
            |.:|::|||..:     .:...:|:.|.||:|||:|...|.:.|...|||.....|:....|.|:
  Fly   651 VTVVLFHARKGM-----VRPQGLKICQFQFNTGFIPEPETLITFTNQDLDDLPDPEQVTPRFCVS 710

Human   705 LEVEVEPRDRPSREAPPWENSSMRGLNPKILFSSREEQQDILSKFGKPELPRQPGSTAQYDAGAG 769
            |.:.|...:.|....|||..:..: .:|..||||..|..::|..|                    
  Fly   711 LSLAVTDSESPPSHKPPWMPAKPK-RSPAALFSSDLEYAEMLDNF-------------------- 754

Human   770 SPEAEPTDSDSPPSSSADASRFLHTLDWQEEKEAETGAENASSKESESALMEDRDESEVSDEGGS 834
              ..:|:...|||                      .||..                   ||...|
  Fly   755 --VTKPSTRSSPP----------------------PGARK-------------------SDRVSS 776

Human   835 PISSEGQEPRADPEPPGLAAGLVQQDLVFEV-ETPAVLPEPVPQEDGVDLLGLHSEVGAGPAVPP 898
            |                    ||..|:.... |.|:.:|||.|.   :|||.|:.:....||..|
  Fly   777 P--------------------LVLPDVTETAHELPSPMPEPSPP---IDLLNLNQQPSDVPAADP 818

Human   899 QACKAPSSNT--DLLSCLLGPPEAASQG--PPEDLLSEDPLLLASPAPPLSVQSTPRGGPPAAAD 959
            .....||::.  |||.. .|..::...|  |..|:|         |.|||   ..|:  |....|
  Fly   819 LTSAKPSTDASFDLLGA-FGDDDSTGIGSAPIPDIL---------PPPPL---QQPQ--PKINND 868

Human   960 PFGPLLPSSGNNSQPCSNPDLFGEFLNSDSVTVPPSFPSAHSAPPPSCSADFLHLGDLP---GEP 1021
            ||                 |:||   :.|...||...||..   ||       .:|.||   .:|
  Fly   869 PF-----------------DIFG---SVDQGGVPSMKPSGF---PP-------FVGSLPTFVAQP 903

Human  1022 SKMTASSSNPDLLGGWAAWTETAASAVAPTPATEGPLFSPGGQPAPCGSQASWTKSQNPDPFADL 1086
                |:::||                 :||            .||...:          ||||::
  Fly   904 ----AATTNP-----------------SPT------------HPARASA----------DPFANI 925

Human  1087 GDLSSGLQDPQAQSTVSPRGQRVCTCSRRLPTGKLKPGVADTGTAASPHRHCGSPAGFPPGGFIP 1151
            .||::||.....:||:|               ||.....:...|..|...|..||:..|...|: 
  Fly   926 ADLATGLNLNFNRSTLS---------------GKSPVNTSPQPTQFSSPTHKPSPSSQPQATFM- 974

Human  1152 KTATTPKGSSSWQTSRPPAQGASWPPQAKPPPKACTQPRPNYAS-NFSVIGAREERGVRAPSFAQ 1215
            .|..||:...|..:.|.|.|     |||.|     .|.||:|:. :|....|.::.|...     
  Fly   975 HTPPTPQTLPSTSSIRTPTQ-----PQAVP-----AQSRPDYSRLHFDSQKAAQQPGTGG----- 1024

Human  1216 KPKVSEND--FEDLLSNQGFSSRSD-KKGPKTIAEMRKQDLAKDTDPLKLKLLDWIEGKERNIRA 1277
                |:|.  |.|:|..||:|..|. .:.|::|.||||:||.||.||.|:::::|.:||:.||||
  Fly  1025 ----SKNSDIFADILGQQGYSFGSKMNQCPRSINEMRKEDLFKDMDPKKVRIMEWTDGKKNNIRA 1085

Human  1278 LLSTLHTVLWDGESRWTPVGMADLVAPEQVKKHYRRAVLAVHPDKAAGQPYEQHAKMIFMELNDA 1342
            ||.::|||||| .::|....|:.:|.|.:|||.||||.|||||||..|...|:.||:||||||:|
  Fly  1086 LLCSMHTVLWD-NAKWQRCEMSTMVTPTEVKKAYRRACLAVHPDKHNGTENEEIAKLIFMELNNA 1149

Human  1343 WSEFENQGSR 1352
            |::|||..::
  Fly  1150 WTDFENDATQ 1159

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GAKXP_011511727.1 STKc_GAK 39..320 CDD:270938 148/281 (53%)
S_TKc 41..309 CDD:214567 143/268 (53%)
PTEN_C2 570..708 CDD:287393 50/137 (36%)
DnaJ <1304..1348 CDD:99751 28/43 (65%)
auxNP_649438.1 PKc_like 49..326 CDD:304357 148/281 (53%)
S_TKc 51..317 CDD:214567 144/270 (53%)
PTEN_C2 581..711 CDD:287393 49/134 (37%)
DnaJ <1110..1150 CDD:197617 25/39 (64%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165155304
Domainoid 1 1.000 278 1.000 Domainoid score I1724
eggNOG 1 0.900 - - E1_KOG0431
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H3846
Inparanoid 1 1.050 545 1.000 Inparanoid score I1166
Isobase 1 0.950 - 0 Normalized mean entropy S4286
OMA 1 1.010 - - QHG45626
OrthoDB 1 1.010 - - D296562at33208
OrthoFinder 1 1.000 - - FOG0001565
OrthoInspector 1 1.000 - - otm42123
orthoMCL 1 0.900 - - OOG6_104372
Panther 1 1.100 - - LDO PTHR23172
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R5536
SonicParanoid 1 1.000 - - X2131
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1716.750

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