Protein Alignment GAK and Gak

DIOPT Version :10

• Sequence 1: XP_011511727.1
• Gene: GAK / 2580
• HGNCID: 4113
• Length: 1355
• Species: Homo sapiens
• Sequence 2: NP_705797.1
• Gene: Gak / 231580
• MGIID: 2442153
• Length: 1305
• Species: Mus musculus
• Alignment Length: 1356
• Identity: 1085/1356 - (80%)
• Similarity: 1161/1356 - (85%)
• Gaps: 52/1356 - (3%)

Human     1 MSLLQSALDFLAGPGSLGGASGRDQSDFVGQTVELGELRLRVRRVLAEGGFAFVYEAQDVGSGRE 65
            ||||||||||||||||||||:||||||||||||||||||||||||||||||||||||||:|||||
Mouse     1 MSLLQSALDFLAGPGSLGGAAGRDQSDFVGQTVELGELRLRVRRVLAEGGFAFVYEAQDLGSGRE 65

Human    66 YALKRLLSNEEEKNRAIIQEVCFMKKLSGHPNIVQFCSAASIGKEESDTGQAEFLLLTELCKGQL 130
            |||||||||||||||||||||||:|||||||||||||||||||||||||||||||||||||||||
Mouse    66 YALKRLLSNEEEKNRAIIQEVCFLKKLSGHPNIVQFCSAASIGKEESDTGQAEFLLLTELCKGQL 130

Human   131 VEFLKKMESRGPLSCDTVLKIFYQTCRAVQHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSA 195
            |||||::|.:||||||::|||||||||||||||||||||||||||||||||||||||||||||||
Mouse   131 VEFLKRVECKGPLSCDSILKIFYQTCRAVQHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSA 195

Human   196 TTISHYPDYSWSAQRRALVEEEITRNTTPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFRQ 260
            ||||||||||||||:||:||||||||||||||||||:||||||||||||||||||||||||||||
Mouse   196 TTISHYPDYSWSAQKRAMVEEEITRNTTPMYRTPEIVDLYSNFPIGEKQDIWALGCILYLLCFRQ 260

Human   261 HPFEDGAKLRIVNGKYSIPPHDTQYTVFHSLIRAMLQVNPEERLSIAEVVHQLQEIAAARNVNPK 325
            |||||||||||||||||||.:||:|||||.||||||:|||||||||||||.||||||||||||||
Mouse   261 HPFEDGAKLRIVNGKYSIPVNDTRYTVFHDLIRAMLKVNPEERLSIAEVVRQLQEIAAARNVNPK 325

Human   326 SPITELLEQNGGYGSATLSRGPPPPVGPAGSGYSGGLALAEYDQPYGGFLDILRGGTERLFTNLK 390
            :|||||||||||||::..||..||..|...|  ||.|||||||||||||||||||||||||||||
Mouse   326 APITELLEQNGGYGNSGPSRAQPPCGGTVNS--SGVLALAEYDQPYGGFLDILRGGTERLFTNLK 388

Human   391 DTSSKVIQSVANYAKGDLDISYITSRIAVMSFPAEGVESALKNNIEDVRLFLDSKHPGHYAVYNL 455
            ||||||||||||||||||||||||||||||||||||||||:||||||||:|||:|||||||||||
Mouse   389 DTSSKVIQSVANYAKGDLDISYITSRIAVMSFPAEGVESAIKNNIEDVRMFLDAKHPGHYAVYNL 453

Human   456 SPRTYRPSRFHNRVSECGWAARRAPHLHTLYNICRNMHAWLRQDHKNVCVVHCMDGRAASAVAVC 520
            |||.||.|:|||||:|||||.|||||||:||.:||:||||||:||:|||||||||||||||||||
Mouse   454 SPRIYRASKFHNRVTECGWAVRRAPHLHSLYTLCRSMHAWLREDHRNVCVVHCMDGRAASAVAVC 518

Human   521 SFLCFCRLFSTAEAAVYMFSMKRCPPGIWPSHKRYIEYMCDMVAEEPITPHSKPILVRAVVMTPV 585
            :|||||||||||||||||||||||||||||||||||||:|||||||||||||||:||::||||||
Mouse   519 AFLCFCRLFSTAEAAVYMFSMKRCPPGIWPSHKRYIEYVCDMVAEEPITPHSKPMLVKSVVMTPV 583

Human   586 PLFSKQRSGCRPFCEVYVGDERVASTSQEYDKMRDFKIEDGKAVIPLGVTVQGDVLIVIYHARST 650
            |||||||:|||||||||||:|||.:||||||:|::||||||||||||||||||||||:|||||:|
Mouse   584 PLFSKQRNGCRPFCEVYVGEERVTTTSQEYDRMKEFKIEDGKAVIPLGVTVQGDVLIIIYHARAT 648

Human   651 LGGRLQAKMASMKMFQIQFHTGFVPRNATTVKFAKYDLDACDIQEKYPDLFQVNLEVEVEPRDRP 715
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   649 LGGRLQAKMASMKMFQIQFHTGFVPRNATTVKFAKYDLDACDIQEKYPDLFQVNLEVEVEPRDRP 713

Human   716 SREAPPWENSSMRGLNPKILFSSREEQQDILSKFGKPELPRQPGSTAQYDAGAGSPEAEPTDSDS 780
            |||||||||:|:||||||||||:||||||||||||||||||||||||||||.|||||||.|:|||
Mouse   714 SREAPPWENTSLRGLNPKILFSNREEQQDILSKFGKPELPRQPGSTAQYDAEAGSPEAEITESDS 778

Human   781 PPSSSADASRFLHTLDWQEEKEAETGAENASSKESESALMEDRDESEVSDEGGSPISSEGQEPRA 845
            |.|||.|.:.||||||||||||.|||.:|.|.|||:|.|:.|.|.||||||..:...||.::|.|
Mouse   779 PQSSSTDTNHFLHTLDWQEEKEPETGLDNTSPKESQSVLIADGDGSEVSDEEEASFPSEERKPGA 843

Human   846 DPEPPGLAAGLVQQDLVFEVETPAVLPEPVPQEDGVDLLGLHSEVGAGPAVPPQACKAPSSNTDL 910
            ..:.|.||||..||||:|:|...|...|||..|:||||||||||....||.|.|||..|||||||
Mouse   844 GEDTPRLAAGTKQQDLIFDVGMLAAPQEPVQPEEGVDLLGLHSEGDLRPAAPLQACGVPSSNTDL 908

Human   911 LSCLLGPPEAASQGPPEDLL-SEDPLLLASPAPPLSVQSTPRGGPPAAADPFGPLLPSSGNNSQP 974
            |||||.|.:||..|||.||| .|.|||||||..||.:|:..:|..|...|||...|.||.:::||
Mouse   909 LSCLLEPSDAAQVGPPGDLLGGEAPLLLASPVSPLGLQNNLQGKVPDTVDPFDQFLLSSNSDTQP 973

Human   975 CSNPDLFGEFLNSDSVTVPPSFPSAHSAPPPSCSADFLHLGDLPGEPSKMTASSSNPDLLGGWAA 1039
            ||.|||||||||||||....:|||.|||||||||..||||||||.||||:.||||:|||||||..
Mouse   974 CSKPDLFGEFLNSDSVASSTAFPSTHSAPPPSCSTAFLHLGDLPAEPSKVIASSSHPDLLGGWDT 1038

Human  1040 WTETAASAVAPTPATEGPLFSPGGQPAPCGSQASWTKSQNPDPFADLGDLSSGLQDPQAQSTVSP 1104
            |.:||....|..|..||.|||..|.|||.|...|.|||||.||||||.||||.||
Mouse  1039 WADTATPGPASIPVPEGTLFSSAGHPAPPGPNPSQTKSQNLDPFADLSDLSSSLQ---------- 1093

Human  1105 RGQRVCTCSRRLPTGKLKPGVADTGTAASPHRHCGSPAGFPPGGFIPKTATTPKGSSSWQTSRPP 1169
                                              |.|||.|.|||:...|.|.|.:|.||.:||.
Mouse  1094 ----------------------------------GLPAGLPAGGFVGAPAPTQKSNSPWQANRPT 1124

Human  1170 AQGASWPPQAKPPPKACTQPRPNYASNFSVIGAREERGVRAPSFAQKPKVSENDFEDLLSNQGFS 1234
            |.|.||.|||||.|:|..|.|    |:|||||||||||||.||||||||||||||||||.||||
Mouse  1125 APGTSWTPQAKPAPRASEQLR----SHFSVIGAREERGVRVPSFAQKPKVSENDFEDLLPNQGF- 1184

Human  1235 SRSDKKGPKTIAEMRKQDLAKDTDPLKLKLLDWIEGKERNIRALLSTLHTVLWDGESRWTPVGMA 1299
            |:||||||||:||||||:||:|||||||||||||||||||||||||||||||||||||||||.||
Mouse  1185 SKSDKKGPKTMAEMRKQELARDTDPLKLKLLDWIEGKERNIRALLSTLHTVLWDGESRWTPVSMA 1249

Human  1300 DLVAPEQVKKHYRRAVLAVHPDKAAGQPYEQHAKMIFMELNDAWSEFENQGSRPLF 1355
            |||.||||||.||||||.||||||.||||||:||||||||||||||||||||||||
Mouse  1250 DLVTPEQVKKQYRRAVLVVHPDKATGQPYEQYAKMIFMELNDAWSEFENQGSRPLF 1305

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GAK	XP_011511727.1	STKc_GAK	39..320	CDD:270938	263/280 (94%)
		PTP_GAK	400..562	CDD:350412	145/161 (90%)
		PTEN_C2	570..708	CDD:463081	125/137 (91%)
		PHA03247	<839..1169	CDD:223021	175/330 (53%)
		DnaJ	<1304..1348	CDD:99751	39/43 (91%)
Gak	NP_705797.1	STKc_GAK	39..320	CDD:270938	263/280 (94%)
		PTP_GAK	398..560	CDD:350412	145/161 (90%)
		PTEN_C2	568..706	CDD:463081	125/137 (91%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	707..732		22/24 (92%)
		PHA03247	<713..1169	CDD:223021	305/503 (61%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	747..854		72/106 (68%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1037..1139		58/145 (40%)
		DnaJ	<1253..1298	CDD:99751	39/44 (89%)