Protein Alignment GAK and gakh-1

DIOPT Version :10

• Sequence 1: XP_011511727.1
• Gene: GAK / 2580
• HGNCID: 4113
• Length: 1355
• Species: Homo sapiens
• Sequence 2: NP_508971.1
• Gene: gakh-1 / 180844
• WormBaseID: WBGene00018516
• Length: 570
• Species: Caenorhabditis elegans
• Alignment Length: 459
• Identity: 148/459 - (32%)
• Similarity: 229/459 - (49%)
• Gaps: 78/459 - (16%)

Human    16 SLG-GASGRDQSDFV--GQTVELGELRLRVRRVLAEGGFAFVYEAQDVGSGREYALKRLLSNEEE 77
            |:| ||...:||:..  |||..:.....||.:|:|:|||..|:.|.:. .|::.|:|.:||::..
 Worm    12 SVGRGAGISEQSELYDRGQTFSINGNNYRVEKVIAKGGFGTVFLATNT-KGKQVAVKIMLSHDAA 75

Human    78 KNRAIIQEVCFMKKLSGHPNIVQFCSAASIGKEESDTGQAEFLLLTELCKGQLVEFLKKMESRGP 142
            ..:.|..|:..||||. |.||:|... ||.....|:....|:.:..|.||..:.:.|.|.:.
 Worm    76 ATKDIDNEIDMMKKLQ-HENIIQLFD-ASAESRSSNRSVKEYKISMEYCKFSIADVLLKYKE--- 135

Human   143 LSCDTVLKIFYQTCRAVQHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATT--ISHYPDYS 205
            :|.|.|::|.|.|.||:.::|  ....||||:|.||||::..|.:||||||||||  |...|
 Worm   136 VSIDFVVRIIYFTTRALVYLH--SVGAIHRDIKAENLLINGNGKLKLCDFGSATTKSIEMAP--- 195

Human   206 WSAQRRALVEEEITRNTTPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFRQHPFEDGAKLR 270
            .|...|..|:||:.:.|||:.|:||:.|:|||:|||::||.||:||::|.:.|.:||| ||:.|.
 Worm   196 LSNSERLAVQEEMFKYTTPITRSPEVCDVYSNWPIGKQQDNWAMGCLIYFVAFGEHPF-DGSALA 259

Human   271 IVNGKYSIPP--HDTQYTVFHSLIRAMLQVNPEERLSIAEVVHQLQEIAAAR--NVNPKSPITEL 331
            |:||||..||  ...|.:.|..||...|..||:||::.|: :.:..::|..:  .:..|:..|::
 Worm   260 IINGKYKKPPPVQQNQLSAFADLIAKCLTPNPDERITAAK-IEEYMKLAMQKQPKLAAKTDFTDI 323

Human   332 LEQNGGYGSATLSRGPPPPVGPAGSGYSGGLALAEYDQPYGGFLDILRGGTERLFTNLKDTSSKV 396
            |:...              |.|..:..|      ...|...||..:    .::||:||....:.|
 Worm   324 LDLMN--------------VQPVQAEQS------IESQAAKGFFTM----QDKLFSNLTSLKNTV 364

Human   397 IQSVANYAKGDLDISYITSRIAVMSFPAEGVESALKNNIEDVRLFLDSKHPGHYAVY-NLSPRTY 460
            :|.......| ::.:..|.|                              |||.:.. .|.|:|:
 Worm   365 VQQTNKMGWG-MEPTNTTPR------------------------------PGHPSTSPKLVPKTH 398

Human   461 RPSR 464
            |.::
 Worm   399 RSNQ 402

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GAK	XP_011511727.1	STKc_GAK	39..320	CDD:270938	114/284 (40%)
		PTP_GAK	400..562	CDD:350412	10/66 (15%)
		PTEN_C2	570..708	CDD:463081
		PHA03247	<839..1169	CDD:223021
		DnaJ	<1304..1348	CDD:99751
gakh-1	NP_508971.1	Protein Kinases, catalytic domain	38..304	CDD:473864	113/278 (41%)