DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ZNF324 and znf180

DIOPT Version :9

Sequence 1:	XP_005258770.1	Gene:	ZNF324 / 25799	HGNCID:	14096	Length:	558	Species:	Homo sapiens
Sequence 2:	NP_001072533.1	Gene:	znf180 / 779988	XenbaseID:	XB-GENE-5829966	Length:	500	Species:	Xenopus tropicalis

Alignment Length:	523	Identity:	196/523 - (37%)
Similarity:	267/523 - (51%)	Gaps:	105/523 - (20%)

- Green bases have known domain annotations that are detailed below.

Human     3 QDQMAFEDVAVYFSQEEWGLLDTAQRALYRRVMLDNFALVASLGLSTSRPRVVIQLERGEEPW-V 66
            |..:.||::|||||:||||.|...|:.||..|||||:..:..||.....|.::.::.:|.:.: :
Frog    11 QAPVKFEEIAVYFSEEEWGCLAEWQKLLYANVMLDNYETLCYLGFIHEIPDIITKIWQGRDLYEL 75

Human    67 PSGTDTTLSRTTYRRRNPGSWSLTED-------RDVSGEWPRAFPDTPPGMTTSVFPVAG-ACHS 123
            |..|            :.||..:.|:       .|::.:        ...:.|..:.:.| .|
Frog    76 PLNT------------SHGSIRIKEELHHPLYLEDLANQ--------QSSIHTQYWQIEGVTC-- 118

Human   124 VKSLQRQRGASPSRERKPTGVSVIYWERLLLGSGSGQASVSLRLTSPLRPPEG----VRLREKTL 184
                 |:|..||              |:|                 |..|.|.    |.||.||.
Frog   119 -----RKRYCSP--------------EQL-----------------PAYPRENRTQVVSLRNKTC 147

Human   185 TEHALLGRQPRTPERQKPCAQEVPGRTFGSAQDLEAAGGRGHHRMGAVWQEPHRLLGGQEPSTWD 249
            ::             .:..|.:|.| ..||.|:              .|.|      |.......
Frog   148 SD-------------SRATANQVYG-NIGSDQE--------------AWNE------GINKKAEC 178

Human   250 ELGEALHAGEKSFECRACSKVFVKSSDLLKHLRTHTGERPYECAQCGKAFSQTSHLTQHQRIHSG 314
            ..|...|..||.:.|..|.|.|.:||.||:|.|.|.|||||.|.:|||:|..:|.|..|:|.|:|
Frog   179 MAGLNSHTTEKYYTCTECGKGFNRSSHLLRHKRIHIGERPYFCGKCGKSFIDSSQLVIHKRTHTG 243

Human   315 ETPYACPVCGKAFRHSSSLVRHQRIHTAEKSFRCSECGKAFSHGSNLSQHRKIHAGGRPYACAQC 379
            |.||||..|.|:|.....||||||.||.|:.:.||:|||.|:..|||..|.:.|.|.:||:||||
Frog   244 EKPYACSDCEKSFICKLHLVRHQRSHTGERPYVCSKCGKGFAQSSNLLTHLRTHTGEKPYSCAQC 308

Human   380 GRRFCRNSHLIQHERTHTGEKPFVCALCGAAFSQGSSLFKHQRVHTGEKPFACPQCGRAFSHSSN 444
            |:.|.|.||:|:|:|.||||.|:.|..||.:|::.|:|.||||.||||||:||.||.::|...|.
Frog   309 GKSFIRRSHVIRHQRIHTGEGPYGCTECGKSFTESSALLKHQRTHTGEKPYACTQCPKSFMDKSA 373

Human   445 LTQHQLLHTGERPFRCVDCGKAFAKGAVLLSHRRIHTGEKPFVCTQCGRAFRERPALFHHQRIHT 509
            |..||..||||||:.|.||||:|:..:.|:.|:||||||||:.|.:|.::|.:..||.:|||.||
Frog   374 LANHQRTHTGERPYPCRDCGKSFSHSSALVKHQRIHTGEKPYACGKCEKSFSQTSALVNHQRTHT 438

Human   510 GEK 512
            |||
Frog   439 GEK 441

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZNF324	XP_005258770.1	KRAB	6..66	CDD:214630	24/60 (40%)
		KRAB	6..45	CDD:279668	20/38 (53%)
		C2H2 Zn finger	264..284	CDD:275368	10/19 (53%)
		COG5048	<268..468	CDD:227381	109/199 (55%)
		zf-H2C2_2	276..301	CDD:290200	15/24 (63%)
		C2H2 Zn finger	292..312	CDD:275368	9/19 (47%)
		zf-H2C2_2	304..329	CDD:290200	13/24 (54%)
		C2H2 Zn finger	320..340	CDD:275368	10/19 (53%)
		zf-H2C2_2	332..357	CDD:290200	15/24 (63%)
		C2H2 Zn finger	348..368	CDD:275368	10/19 (53%)
		zf-C2H2	374..396	CDD:278523	13/21 (62%)
		C2H2 Zn finger	376..396	CDD:275368	12/19 (63%)
		zf-H2C2_2	388..413	CDD:290200	13/24 (54%)
		C2H2 Zn finger	404..424	CDD:275368	10/19 (53%)
		zf-H2C2_2	416..441	CDD:290200	16/24 (67%)
		C2H2 Zn finger	432..452	CDD:275368	8/19 (42%)
		COG5048	437..>524	CDD:227381	40/76 (53%)
		zf-H2C2_2	444..468	CDD:290200	14/23 (61%)
		C2H2 Zn finger	460..480	CDD:275368	9/19 (47%)
		zf-H2C2_2	473..495	CDD:290200	12/21 (57%)
		C2H2 Zn finger	488..508	CDD:275368	8/19 (42%)
znf180	NP_001072533.1	KRAB	13..54	CDD:307490	20/40 (50%)
		COG5048	189..465	CDD:227381	136/253 (54%)
		C2H2 Zn finger	193..213	CDD:275368	10/19 (53%)
		C2H2 Zn finger	221..241	CDD:275368	9/19 (47%)
		C2H2 Zn finger	249..269	CDD:275368	10/19 (53%)
		C2H2 Zn finger	277..297	CDD:275368	10/19 (53%)
		C2H2 Zn finger	305..325	CDD:275368	12/19 (63%)
		C2H2 Zn finger	333..353	CDD:275368	10/19 (53%)
		C2H2 Zn finger	361..381	CDD:275368	8/19 (42%)
		C2H2 Zn finger	389..409	CDD:275368	9/19 (47%)
		C2H2 Zn finger	417..437	CDD:275368	8/19 (42%)
		C2H2 Zn finger	445..465	CDD:275368
		zf-H2C2_2	457..482	CDD:316026
		C2H2 Zn finger	473..493	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010