Protein Alignment FBXO7 and MET30

DIOPT Version :10

• Sequence 1: NP_036311.3
• Gene: FBXO7 / 25793
• HGNCID: 13586
• Length: 522
• Species: Homo sapiens
• Sequence 2: NP_012218.1
• Gene: MET30 / 854765
• SGDID: S000001308
• Length: 640
• Species: Saccharomyces cerevisiae
• Alignment Length: 329
• Identity: 64/329 - (19%)
• Similarity: 116/329 - (35%)
• Gaps: 100/329 - (30%)

Human   114 SMQDEQPSDSFQGQAAQSGVWNDDSMLGPSQNFEAESIQDNAHMAEGTGFYPSEPMLCSESVEGQ 178
            |.:|:...|.....:..|....|.:|:.|.:........|:  :|:|:              .|:
Yeast    10 SFEDKDKDDLDNSNSNNSSEMTDTAMMPPLKRLLITGSSDD--LAQGS--------------SGK 58

Human   179 VPHSLETLYQSADCSDA-NDALIVLIHLLMLESGYIPQGTEAKALSMPEKWKLSGVYKLQYMH-P 241
            ...::.|...|:....| ||:                 ||..:.|  ||    ....|..|.| |
Yeast    59 KKMTMATRSPSSSPDLATNDS-----------------GTRVQPL--PE----YNFTKFCYRHNP 100

Human   242 LCEGSSATLTCVPLGNLIVVNATLKINNEIR-SVKRLQLLPESFICKEKLGENVANIYKDL-QKL 304
            ..:.|.....|        ....||...||. ::.:|.|..:|.|      .::.:.|.:. .|:
Yeast   101 DIQFSPTHTAC--------YKQDLKRTQEINANIAKLPLQEQSDI------HHIISKYSNSNDKI 151

Human   305 SRLFKDQLV----YPLLAFTRQAL-NLPDVFGLVVLPLELKLRIFRLLDVRSVLSLSAVCRDLFT 364
            .:|..|.::    :|.|::....: ::..:..:.:||.||.|:|...||.:|:.:.:.|||....
Yeast   152 RKLILDGILSTSCFPQLSYISSLVTHMIKIDFISILPQELSLKILSYLDCQSLCNATRVCRKWQK 216

Human   365 ASNDPLLW-------------------RFLYLR---------------DFRDNTVRVQDTDWKEL 395
            .::|..:|                   ..|:::               |.:..|.|    .||.:
Yeast   217 LADDDRVWYHMCEQHIDRKCPNCGWGLPLLHMKRARIQQNSTGSSSNADIQTQTTR----PWKVI 277

Human   396 YRKR 399
            ||:|
Yeast   278 YRER 281

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FBXO7	NP_036311.3	Ubiquitin-like	1..88
		Ubl1_cv_Nsp3_N-like	1..77	CDD:475130
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	85..144		7/29 (24%)
		Important for interaction with PINK1. /evidence=ECO:0000269|PubMed:23933751	92..129		3/14 (21%)
		Important for interaction with CDK6	129..169		7/39 (18%)
		Important for dimerization and interaction with PSMF1. /evidence=ECO:0000269|PubMed:18495667	180..324		30/151 (20%)
		PI31_Prot_N	189..317	CDD:463296	28/135 (21%)
		F-box_FBXO7	332..376	CDD:438859	14/62 (23%)
		Important for interaction with CDK6	381..522		7/19 (37%)
		PHA03247	<431..520	CDD:223021
		RFDP motif	481..484
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	483..522
MET30	NP_012218.1	F-box_SpPof1-like	183..228	CDD:438918	14/44 (32%)
		WD40	295..590	CDD:238121
		WD40 repeat	305..340	CDD:293791
		WD40 repeat	346..380	CDD:293791
		WD40 repeat	385..418	CDD:293791
		WD40 repeat	425..460	CDD:293791
		WD40 repeat	488..549	CDD:293791