DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NGEF and Exn

DIOPT Version :9

Sequence 1:	NP_062824.2	Gene:	NGEF / 25791	HGNCID:	7807	Length:	710	Species:	Homo sapiens
Sequence 2:	NP_001097630.2	Gene:	Exn / 39900	FlyBaseID:	FBgn0261547	Length:	2029	Species:	Drosophila melanogaster

Alignment Length:	777	Identity:	229/777 - (29%)
Similarity:	349/777 - (44%)	Gaps:	150/777 - (19%)

- Green bases have known domain annotations that are detailed below.

Human     2 ETRESEDLEKTRRKSASDQWNTDNEPAKVKPELLPEKEETSQADQDIQDKEPHCHIPIKRNSIFN 66
            :|::...|..||    |..:..|.|.:.....|.||...:.:.|....||  :| .|:.....|:
  Fly  1298 DTKQLSSLAPTR----STFYVEDPEGSLPALPLEPEIHGSGELDSGFSDK--NC-TPLPETPKFS 1355

Human    67 RSIRRKSKAKARDNPERNASCLADSQDNGKSVNEPLTLNIPWSRMPPCRTAMQT--DPGAQEMSE 129
             ::.||:|.:|:.|..|...        |...|:|       ...||..|..::  ||..:..:|
  Fly  1356 -TVARKAKKEAKANRRRTTI--------GLRPNDP-------PPPPPPMTGNKSPLDPERELDAE 1404

Human   130 SSST----------PGNGATPEEWPALADSPTTLTEALRMIHPIPA-----DSW---RNLIEQIG 176
            .:::          ..|||....    .|.|.|         |.|:     .||   ..|.:..|
  Fly  1405 QTTSWYAECGVFKQATNGAVSPR----GDEPVT---------PTPSGHGGVSSWYAESGLYQTSG 1456

Human   177 L-----------------------------------LYQEYRDKSTLQEIETRRQQDAEIEDNTN 206
            :                                   |||.| ..:.|:.| ||   |.|...:::
  Fly  1457 ISVASSSGSSGVSTGNEAGLGDELSSEPHSLFSNEPLYQMY-SAAKLESI-TR---DLEAHGSSD 1516

Human   207 GSPASEDTPEEEE---EEEEEEEPASPPERKTLPQICLLSNPHSRFNLWQDLPEIRSSGVLEILQ 268
            |         .||   :.:.:.||...| |.|..|:....|..|| .||.::||:..|.:|..|.
  Fly  1517 G---------YEEIGLQAKAKPEPLVKP-RPTALQLVEPKNGPSR-TLWSEIPEVIHSCILPTLT 1570

Human   269 PEEIKLQEAMFELVTSEASYYKSLNLLVSHFMENERI--RKILHPSEAHILFSNVLDVLAVSERF 331
            ..|..||||.||::||||||.||||||..|||.:...  ..:|...:...|||.::.|...|||.
  Fly  1571 SRERSLQEAKFEIITSEASYLKSLNLLRRHFMNHNAFLDSSVLSAKDRKALFSYIVPVHECSERL 1635

Human   332 LLELEHRMEENIVISDVCDIVYRYAADHFSVYITYVSNQTYQERTYKQLLQ--EKAAFRELIAQL 394
            |.|||...::||::..:...:|..|..||.||:.:..:|...:||.::|.:  |..||::.:.:|
  Fly  1636 LTELEACWQDNIMLLGLSRCIYEIAERHFHVYVAFCEHQGRMDRTLRRLKESKESLAFQQHLERL 1700

Human   395 ELDPKCRGLPFSSFLILPFQRITRLKLLVQNI------LKRVEERSERECTALDAHKELEMVVKA 453
            |..|.|.||...|||:||.||||||.||:..:      |.|.|..|.:...||     ::.||..
  Fly  1701 EASPSCCGLNLHSFLMLPMQRITRLPLLIDAVFSKESPLNREEYESWKLTLAL-----VQKVVGQ 1760

Human   454 CNEGVRKMSRTEQMISIQKKMEF--KIKSVPII--------SHSRWLLKQGELQQM--SGPKTSR 506
            |||...:..:..::..|.:::||  .::::.|.        :..|:|:|:|||..:  .|.....
  Fly  1761 CNEAANRWEQAFELERIARQLEFPSHVRALAIAPVGVPRAGAKPRFLVKRGELTHLLWRGEDAKL 1825

Human   507 TLRTKKLFHEIYLFLFNDLLVICRQIPGDKYQVFDSAPRGLLRV-----------EELEDQGQTL 560
            |...:.....||.|||:|||::|::.....:.|||..||.:|.:           ::|:||..
  Fly  1826 TFGKRLTKISIYAFLFSDLLLLCKRRGESCFSVFDYCPRSMLTLAAGDSLPQLPTKDLKDQAG-- 1888

Human   561 ANVFILRLLENADDREATYMLKASSQSEMKRWMTSLAPNRRTKFVSFTSRLLDCPQVQCVHPYVA 625
            .|:.::.||||.|.:....:|...|.|:.:||:.::.|..............|||||...|.|.:
  Fly  1889 KNLILMTLLENCDRKTVELVLSCPSVSDQQRWLQAMRPPEAETPGEKLYESWDCPQVVAKHSYES 1953

Human   626 QQPDELTLELADILNILDKTDDGWIFGERLHDQERGWFPSSMTEEILNPKIRSQNLKECFRV 687
            .:||.|.|||.|::|:..|..|||..|||:.|...||||.|.|||:.:..:|::|||:..|:
  Fly  1954 DEPDVLQLELGDVVNVSRKLPDGWYQGERIRDGAVGWFPGSYTEELNSAHVRARNLKQRHRL 2015

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NGEF	NP_062824.2	Regulatory region, modulates activity toward RHOA, RAC1 and CDC42. /evidence=ECO:0000250	1..273		73/328 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..143		34/152 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	194..236		10/44 (23%)
		RhoGEF	277..456	CDD:279015	73/188 (39%)
		PH_ephexin	477..603	CDD:269929	39/146 (27%)
		PH	490..596	CDD:278594	36/118 (31%)
		SH3_ephexin1	616..670	CDD:212872	26/53 (49%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	687..710		0/1 (0%)
Exn	NP_001097630.2	RhoGEF	1581..1763	CDD:279015	72/186 (39%)
		PH_ephexin	1805..1931	CDD:269929	38/127 (30%)
		SH3_ephexin1_like	1944..1998	CDD:212727	26/53 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	117	1.000	Domainoid score	I5908
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001805
OrthoInspector	1	1.000	-	-		otm41472
orthoMCL	1	0.900	-	-		OOG6_105893
Panther	1	1.100	-	-	O	PTHR12845
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3601
SonicParanoid	1	1.000	-	-		X1705
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.840