DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RAD54B and Rad54b

DIOPT Version :9

Sequence 1:	NP_036547.1	Gene:	RAD54B / 25788	HGNCID:	17228	Length:	910	Species:	Homo sapiens
Sequence 2:	NP_001034645.1	Gene:	Rad54b / 623474	MGIID:	3605986	Length:	886	Species:	Mus musculus

Alignment Length:	908	Identity:	711/908 - (78%)
Similarity:	795/908 - (87%)	Gaps:	26/908 - (2%)

- Green bases have known domain annotations that are detailed below.

Human     1 MRRSAAPSQLQGNSFKKPKFIPPGRSNPGLNEEITKLNPDIKLFEGVAINNTFLPSQNDLRICSL 65
            |||||||||:||.||||.:||||||||..:::||||::||.|||:|..      .||||..:||.
Mouse     1 MRRSAAPSQVQGKSFKKTRFIPPGRSNADVSKEITKMSPDPKLFQGAE------QSQNDPGVCSS 59

Human    66 N-LPSEESTREINNRDNCSGKYCFEAPTLATLDPPHTVHSAPKEVAVSKEQEEKSDSLVKYFSVV 129
            | .|||...||:.:.              ..:||...||||.||:..||.|||::.||:||||||
Mouse    60 NPCPSEGIPREVGDG--------------TRVDPLPPVHSASKEITESKAQEEEASSLLKYFSVV 110

Human   130 WCKPSKKKHKKWEGDAVLIVKGKSFILKNLEGKDIGRGIGYKFKELEKIEEGQTLMICGKEIEVM 194
            |||.||||||||||||:|||:|:||.||:|||||||||||||||:||.:||||||:|.|||||::
Mouse   111 WCKASKKKHKKWEGDAILIVRGRSFTLKDLEGKDIGRGIGYKFKDLENVEEGQTLIIGGKEIEIL 175

Human   195 GVISPDDFSSGRCFQLGGGSTAISHSSQVARKCFSNPFKSVCKPSSKENRQNDFQNCKPRHDPYT 259
            |.||.|||:||:|||.|.||.|:. |||.|||||||||||||:.:..:.::  :.:|:|||:|.|
Mouse   176 GTISSDDFNSGKCFQHGSGSPAVP-SSQAARKCFSNPFKSVCQSTQAQGKR--WNDCRPRHNPCT 237

Human   260 PNSLVMPRPDKNHQWVFNKNCFPLVDVVIDPYLVYHLRPHQKEGIIFLYECVMGMRMNGRCGAIL 324
            ||:|||||||:|||.:||::|.|:|||||||:||:|||||||:|||||||||||||..|:|||||
Mouse   238 PNALVMPRPDENHQRMFNRHCSPIVDVVIDPHLVHHLRPHQKDGIIFLYECVMGMRAVGKCGAIL 302

Human   325 ADEMGLGKTLQCISLIWTLQCQGPYGGKPVIKKTLIVTPGSLVNNWKKEFQKWLGSERIKIFTVD 389
            ||||||||||||||||||||||||||||||||||||||||||||||:||||||||||||||||||
Mouse   303 ADEMGLGKTLQCISLIWTLQCQGPYGGKPVIKKTLIVTPGSLVNNWRKEFQKWLGSERIKIFTVD 367

Human   390 QDHKVEEFIKSIFYSVLIISYEMLLRSLDQIKNIKFDLLICDEGHRLKNSAIKTTTALISLSCEK 454
            |||||||||.|.|:||||||||||||||||||.|.|.|||||||||||||:|||||||.||||||
Mouse   368 QDHKVEEFINSTFHSVLIISYEMLLRSLDQIKTIPFGLLICDEGHRLKNSSIKTTTALSSLSCEK 432

Human   455 RIILTGTPIQNDLQEFFALIDFVNPGILGSLSSYRKIYEEPIILSREPSASEEEKELGERRAAEL 519
            .:||||||:||||||||||:|||||||||||||||||||||||:|||||:|:||:|||||||.||
Mouse   433 TVILTGTPVQNDLQEFFALVDFVNPGILGSLSSYRKIYEEPIIISREPSSSKEERELGERRATEL 497

Human   520 TCLTGLFILRRTQEIINKYLPPKIENVVFCRPGALQIELYRKLLNSQVVRFCLQGLLENSPHLIC 584
            |.|||.||||||||:|||||||||||||||||||||||||||||.||.||||||||||||.||||
Mouse   498 TRLTGRFILRRTQEVINKYLPPKIENVVFCRPGALQIELYRKLLRSQSVRFCLQGLLENSAHLIC 562

Human   585 IGALKKLCNHPCLLFNSIKEKECSSTCDKNEEKSLYKGLLSVFPADYNPLLFTEKESGKLQVLSK 649
            |||||||||||||||:|:|.||.||:|::|||::|.:||||||||.||||.|:|:||||||||.|
Mouse   563 IGALKKLCNHPCLLFSSVKGKEFSSSCEENEERNLCQGLLSVFPAGYNPLQFSEEESGKLQVLVK 627

Human   650 LLAVIHELRPTEKVVLVSNYTQTLNILQEVCKRHGYAYTRLDGQTPISQRQQIVDGFNSQHSSFF 714
            ||||||||||||||:|||||.||||:|:|||||||||..|||||||:||||.|||.|||::|:.|
Mouse   628 LLAVIHELRPTEKVILVSNYRQTLNVLEEVCKRHGYACARLDGQTPVSQRQHIVDSFNSKYSTDF 692

Human   715 IFLLSSKAGGVGLNLIGGSHLILYDIDWNPATDIQAMSRVWRDGQKYPVHIYRLLTTGTIEEKIY 779
            ||||||||||||||||||||||||||||||||||||||||||||||:||||||||||||||||||
Mouse   693 IFLLSSKAGGVGLNLIGGSHLILYDIDWNPATDIQAMSRVWRDGQKHPVHIYRLLTTGTIEEKIY 757

Human   780 QRQISKQGLCGAVVDLTKTSEHIQFSVEELKNLFTLHESSDCVTHDLLDCECTGEEVHTGDSLEK 844
            |||||||||.|||||||::|||||||||||||||||||||.||||||||||||||:.||.|:.|.
Mouse   758 QRQISKQGLSGAVVDLTRSSEHIQFSVEELKNLFTLHESSHCVTHDLLDCECTGEKGHTEDASEG 822

Human   845 FIVSRDCQLGPHHQKSNSLKPLSMSQLKQWKHFSGDHLNLTDPFLERITENVSFIFQNITTQA 907
            .:.||.||.||  |||::|:||||||||||||||||||||.|||||||.|||||.|||||.||
Mouse   823 PVASRQCQFGP--QKSDALRPLSMSQLKQWKHFSGDHLNLPDPFLERIRENVSFFFQNITNQA 883

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RAD54B	NP_036547.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..33		23/31 (74%)
		HepA	<296..815	CDD:223627	457/518 (88%)
		DEGH box	431..434		2/2 (100%)
Rad54b	NP_001034645.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..95		54/113 (48%)
		SNF2_N	277..576	CDD:278600	270/298 (91%)
		DEXDc	299..440	CDD:238005	129/140 (92%)
		DEGH box	409..412		2/2 (100%)
		HDA2-3	531..807	CDD:288366	238/275 (87%)
		Helicase_C	619..736	CDD:278689	102/116 (88%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83955122
Domainoid	1	1.000	517	1.000	Domainoid score	I7114
eggNOG	1	0.900	-	-		E2759_KOG0390
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8240
Inparanoid	1	1.050	1426	1.000	Inparanoid score	I3296
Isobase	0	0.000	Not matched by this tool.
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG42468
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001533
OrthoInspector	1	1.000	-	-		oto119640
orthoMCL	1	0.900	-	-		OOG6_105504
Panther	1	1.100	-	-	LDO	PTHR45629
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8216
SonicParanoid	1	1.000	-	-		X6349
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	18.290