DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SUN2 and koi

DIOPT Version :9

Sequence 1:	XP_024307971.1	Gene:	SUN2 / 25777	HGNCID:	14210	Length:	810	Species:	Homo sapiens
Sequence 2:	NP_001260738.1	Gene:	koi / 35594	FlyBaseID:	FBgn0265003	Length:	965	Species:	Drosophila melanogaster

Alignment Length:	969	Identity:	248/969 - (25%)
Similarity:	372/969 - (38%)	Gaps:	304/969 - (31%)

- Green bases have known domain annotations that are detailed below.

Human    35 IMSRRSQRLTRYSQGDDDGSSSSGGSSVAGSQSTLFKDSPLRTLKRKSSNMKRLSPAPQLGPSSD 99
            |:::||...|         |:....|.:..:|:||  :|....|.:.:.|:..       |..||
  Fly   103 ILTKRSGGAT---------STPRNRSQLETTQNTL--NSAQEKLNQSNGNLSS-------GNVSD 149

Human   100 --AHTSY----------------YSESLVHESWFPP---------RSSLEELHGDANWGECGALR 137
              |:..|                |||...|.....|         |.|||. |.|         |
  Fly   150 YLAYIEYRDAGEYWNKTPKTDYTYSELSPHRRQLAPGIVAMPNMSRKSLEN-HND---------R 204

Human   138 PGALLPRPPA-------RYSSQCPLQSPGFPPQSTSLPRPHFSEALGGPEEPLVLPCTGEDLRVR 195
            ...::.:.||       ||.|:       :..|.............|..::...|        :|
  Fly   205 VNYMVQQNPAQEEFIRRRYQSK-------YTQQVNYDSADELDATFGQQKQSWWL--------IR 254

Human   196 RRRGTGGSESSRASGLVGRKATEDFLGSSSGYSSEDDYVGYSDVDQQSSSSRLRSAVSRAGSLLW 260
            ..:....|.::..|.:....|||           ...|..|....|||...          .|.|
  Fly   255 LIQLVVSSITTVWSRVTNLSATE-----------TTAYQNYHAKRQQSQQV----------GLWW 298

Human   261 MVATSPG----RLFRLLYWWAGT-----TWYRLTTAASLLDVFVLTRRFSSLKTFLWF---LLPL 313
            .:..:.|    .|.|.||.:.|:     ||...::.|          ...|.|.||.|   ||||
  Fly   299 KIVQTIGGGLASLLRYLYVFIGSVLSLDTWLLRSSDA----------ENKSKKRFLIFLLILLPL 353

Human   314 LLLTCLTYGAWY----------------FYPYGLQTF----------HPALVSWWAAKDSRRPDE 352
            |||:     .|.                ..|..|..|          ...|.||......|.|..
  Fly   354 LLLS-----GWLLLQEDQRSAYVQRAEALLPLPLSIFGSLRSRFSNAGATLKSWMEVPTVRSPQR 413

Human   353 GWEA---------RDSSPHFQAE--QRVMSRVHSLERRLEALAAEFSS------------NWQKE 394
            ..||         ::......||  :.:::.|:|..::|..|..:..|            ...||
  Fly   414 EAEAIKVNMASIEQNIQKALTAEEYENILNHVNSYVQQLVELKMQQHSKELAPQQIELFVKLMKE 478

Human   395 -------------------AMRLERLELRQGAPGQGGGGGLS-----------------HE---- 419
                               |::| :||| |.:.|...|..||                 ||
  Fly   479 NLKQIMYKTELSEKDLSDLAIKL-KLEL-QSSGGWQDGAKLSQANLEEITKLIKAEVHLHESHYT 541

Human   420 ------DTLALLEGLVSRREAALKEDFRRETAARIQEELSALRAEHQQDSED------------L 466
                  |..:|||.:::   |....||   ..|||...:..|..:....|.|            .
  Fly   542 IQLDRIDFASLLERILA---APALADF---VDARISLRVGELEPKESSGSSDAEVQIERLNREIA 600

Human   467 FKKIVRASQESE-----ARIQQLKSEWQSMTQESFQESSVKELRRLEDQLAGLQQELAA------ 520
            |.|:..:.:::|     ..|..||...:.:. |..|:..:.:.||....||.::.:|:|
  Fly   601 FIKLALSDKQAENADLHQSISNLKLGQEDLL-ERIQQHELSQDRRFHGLLAEIENKLSALNDSQF 664

Human   521 --------------LALKQSSVAEEVGLLPQQIQAVRDDVESQFPAWI-SQFLARGGGGRVGLLQ 570
                          |..|||:.....|.|        ||.:.|  .|: |.|:|
  Fly   665 ALLNKQIKLSLVEILGFKQSTAGGSAGQL--------DDFDLQ--TWVRSMFVA----------- 708

Human   571 REEMQAQLRELESKILTHVAEMQGKSAREAAASLSLTLQKEGVI---------------GVTEEQ 620
            ::.::.||.||..:...::.:...:|:....:.:|..|::|.::               .:.||:
  Fly   709 KDYLEQQLLELNKRTNNNIRDEIERSSILLMSDISQRLKREILLVVEAKHNESTKALKGHIREEE 773

Human   621 VHHIVKQALQRYSEDRIGLADYALESGGASVISTRCSETYETKTALLSLFGIPLWYHSQSPRVIL 685
            |..|||..|..|..|:.||.|:||||.|..::||||:|:|:||:|.:|:|||||||.:.:|||.:
  Fly   774 VRQIVKTVLAIYDADKTGLVDFALESAGGQILSTRCTESYQTKSAQISVFGIPLWYPTNTPRVAI 838

Human   686 QPDVHPGNCWAFQGPQGFAVVRLSARIRPTAVTLEHVPKALSPNSTISSAPKDFAIFGFDEDLQQ 750
            .|:|.||.||||||..||.|::|::.:..|..||||:||:|||...|.|||::|.::|.:::..|
  Fly   839 SPNVQPGECWAFQGFPGFLVLKLNSLVYVTGFTLEHIPKSLSPTGRIESAPRNFTVWGLEQEKDQ 903

Human   751 EGTLLGKFTYDQDGEPIQTFHFQ-APTMATYQVVELRILTNWGHPEYTCIYRFRVHGEP 808
            |..|.|.:.::.:|..:|.|..| ......|::|||||.||.|||.|||:|||||||:|
  Fly   904 EPVLFGDYQFEDNGASLQYFAVQNLDIKRPYEIVELRIETNHGHPTYTCLYRFRVHGKP 962

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SUN2	XP_024307971.1	SMC_N	<364..640	CDD:330553	79/388 (20%)
SUN2	XP_024307971.1	Sad1_UNC	674..808	CDD:311603	65/134 (49%)
koi	NP_001260738.1	Sad1_UNC	827..962	CDD:285038	65/134 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	158	1.000	Domainoid score	I4120
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000864
OrthoInspector	1	1.000	-	-		otm41361
orthoMCL	1	0.900	-	-		OOG6_102039
Panther	1	1.100	-	-	LDO	PTHR12911
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2888
SonicParanoid	1	1.000	-	-		X471
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.940