DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Cacna1b and para

DIOPT Version :9

Sequence 1:XP_006233631.1 Gene:Cacna1b / 257648 RGDID:628852 Length:2359 Species:Rattus norvegicus
Sequence 2:NP_001259619.1 Gene:para / 32619 FlyBaseID:FBgn0285944 Length:2145 Species:Drosophila melanogaster


Alignment Length:2361 Identity:550/2361 - (23%)
Similarity:914/2361 - (38%) Gaps:759/2361 - (32%)


- Green bases have known domain annotations that are detailed below.


  Rat    69 FTVNRSLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDT 133
            |:.::::::....|.:|:.|..|...|.|...|:.||:.|||::.:          |.:..::.|
  Fly   127 FSASKAMWMLDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM----------PTTPTVEST 181

  Rat   134 EPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILATAGTDF-DLRTLRAVRVL 197
            |..|.||:.||:.:|::|.||:....:|||:.||.:||||:....: |.|.|. :|..||..|||
  Fly   182 EVIFTGIYTFESAVKVMARGFILCPFTYLRDAWNWLDFVVIALAYV-TMGIDLGNLAALRTFRVL 245

  Rat   198 RPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKAC---FP---- 255
            |.||.|:.:|.|:.::.::::::..|..:.:|..|::.:||::||:.|||...:.|   ||    
  Fly   246 RALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCIKKFPLDGS 310

  Rat   256 --NSTD--------------AEPVG-DFP-CGKEAPARLCDSDTECRE-YWPGPNFGITNFDNIL 301
              |.||              :|..| .|| ||..:.|..||.|..|.: :.|.||:|.|:||:..
  Fly   311 WGNLTDENWDYHNRNSSNWYSEDEGISFPLCGNISGAGQCDDDYVCLQGFGPNPNYGYTSFDSFG 375

  Rat   302 FAILTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEF------A 360
            :|.|:.|:.:|.:.|.| ||.....|...|:.|:||.:|.:|||:::||:|.:::..:      |
  Fly   376 WAFLSAFRLMTQDFWED-LYQLVLRAAGPWHMLFFIVIIFLGSFYLVNLILAIVAMSYDELQKKA 439

  Rat   361 KERERVEN------------RRAFLKLRRQQQIERELNGYLEWIFKAEEVMLAEE---------- 403
            :|.|..|.            :.|.|:.|...|.:...:.     ..|||..|..|          
  Fly   440 EEEEAAEEEAIREAEEAAAAKAAKLEERANAQAQAAADA-----AAAEEAALHPEMAKSPTYSCI 499

  Rat   404 ------------DKNAEEKSPLDAV---------------------------------------- 416
                        |.|.:||..:.:|                                        
  Fly   500 SYELFVGGEKGNDDNNKEKMSIRSVEVESESVSVIQRQPAPTTAHQATKVRKVSTTSLSLPGSPF 564

  Rat   417 -LKRAA----------------------------------------------------------- 421
             ::|.:                                                           
  Fly   565 NIRRGSRSSHKYTIRNGRGRFGIPGSDRKPLVLSTYQDAQQHLPYADDSNAVTPMSEENGAIIVP 629

  Rat   422 ----------------------------------------TKKS-------RNDLIHAEEGEDRF 439
                                                    ||:|       ||..:.|..|....
  Fly   630 VYYGNLGSRHSSYTSHQSRISYTSHGDLLGGMAVMGVSTMTKESKLRNRNTRNQSVGATNGGTTC 694

  Rat   440 VDL--------------CA--AG------SPF--------------------------ARASLKS 456
            :|.              |.  ||      :||                          .|.|..|
  Fly   695 LDTNHKLDHRDYEIGLECTDEAGKIKHHDNPFIEPVQTQTVVDMKDVMVLNDIIEQAAGRHSRAS 759

  Rat   457 GKTESSSYFRR----------KEKMFRFLIRRM------------VKAQSF-----------YWV 488
            .:..|..||..          |:|....:::.:            :|.|.:           .::
  Fly   760 DRGVSVYYFPTEDDDEDGPTFKDKALEVILKGIDVFCVWDCCWVWLKFQEWVSLIVFDPFVELFI 824

  Rat   489 VLCVVALNTLCVAMVHYNQPQRLTTALYFAEFVFLGLFLTEMSLKMYGLGPRSYFRSSFNCFDFG 553
            .||:| :||:.:||.|::..:.:...|....:.|...|..|.::|:..:.|:.||:..:|.|||.
  Fly   825 TLCIV-VNTMFMAMDHHDMNKEMERVLKSGNYFFTATFAIEATMKLMAMSPKYYFQEGWNIFDFI 888

  Rat   554 VIVGSIFEVVWAAIKPGTSFGISVLRALRLLRIFKVTKYWNSLRNLVVSLL-NSMKSIISLLFLL 617
            ::..|:.|:....::     |:||||:.||||:||:.|.|.:| ||::|:: .:|.::.:|.|:|
  Fly   889 IVALSLLELGLEGVQ-----GLSVLRSFRLLRVFKLAKSWPTL-NLLISIMGRTMGALGNLTFVL 947

  Rat   618 FLFIVVFALLGMQLFGGQFN-----FQD-ETPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIES 676
            .:.|.:||::||||||..::     |.| :.|..||..|..:.:.||::|.|| |       |||
  Fly   948 CIIIFIFAVMGMQLFGKNYHDHKDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-W-------IES 1004

  Rat   677 Q------GGVSKGMFSSFYFIVLTLFGNYTLLNVFLAIAVDNLA----NAQELTKDEEEMEEAAN 731
            .      |.||...|    |:...:.||..:||:|||:.:.|..    :|.....|..::.||.|
  Fly  1005 MWDCMYVGDVSCIPF----FLATVVIGNLVVLNLFLALLLSNFGSSSLSAPTADNDTNKIAEAFN 1065

  Rat   732 QKLALQKAKEVAEVSPMSAANISIAAFVKQTRGTVSRSSSVSSVNSPRQQNSAKARSVWEQRASQ 796
            :   :.:.|        |....:||...|..|..::...|    :.|..:.:.:...:|.:.   
  Fly  1066 R---IGRFK--------SWVKRNIADCFKLIRNKLTNQIS----DQPSGERTNQISWIWSEG--- 1112

  Rat   797 LRLQNLRASCEALYSEMDPEERLRYASTRHVRPDMKTHMDRPLVVEPGRDGLRGPA----GNKSK 857
                  :..|..:.:|                     |.|..|  |.|.|.:....    |.|.:
  Fly  1113 ------KGVCRCISAE---------------------HGDNEL--ELGHDEILADGLIKKGIKEQ 1148

  Rat   858 P-------EGTEATEGAD-----PPRRHHRHRDRDKTSASTPAGGEQDRTDCPKAESTETGAREE 910
            .       :|.|.|...|     |.:..:.:...|..:||..:.|                  ..
  Fly  1149 TQLEVAIGDGMEFTIHGDMKNNKPKKSKYLNNATDDDTASINSYG------------------SH 1195

  Rat   911 RARPRRSHSKEAPGADTQVRCERSRRHHRRGSPEEATEREPRRHRAHRHAQDSSKEGKEGTAPVL 975
            :.||.:..|                   .:||.|                               
  Fly  1196 KNRPFKDES-------------------HKGSAE------------------------------- 1210

  Rat   976 VPKGERRARHRGPRTGPRETENSEEPTRRHRAKHKVPPTLEPPEREVAEKESNVVEGDKETRNHQ 1040
                                                  |:|..|:..|.||              
  Fly  1211 --------------------------------------TMEGEEKRDASKE-------------- 1223

  Rat  1041 PKEPRCDLEAIAVTGVGSLHMLPSTCLQKVDEQPEDADNQRNVTRMGSQPSDPSTTVHVPVTLTG 1105
                  ||      |:.          :::||:.|..:.          |.|....:|       
  Fly  1224 ------DL------GLD----------EELDEEGECEEG----------PLDGDIIIH------- 1249

  Rat  1106 PPGEATVVPSANTDLEGQAEGKKEAEADDVLRRGPRPIVPYS-------------SMFCLSPTNL 1157
                                    |..:|:|...|....|.|             |.|.....||
  Fly  1250 ------------------------AHDEDILDEYPADCCPDSYYKKFPILAGDDDSPFWQGWGNL 1290

  Rat  1158 -LRRFCHYIVTMRYFEMVILVVIALSSIALAAED------PVRTDSFRNNALKYMDYIFTGVFTF 1215
             |:.|  .::..:|||..::.:|.:||:|||.||      |:..|     .|.|||.|||.:|..
  Fly  1291 RLKTF--QLIENKYFETAVITMILMSSLALALEDVHLPQRPILQD-----ILYYMDRIFTVIFFL 1348

  Rat  1216 EMVIKMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSSFMGGSKGKDINTIKSLRVLRVLR 1280
            ||:||.:.||..:    ||.:.|..|||::|..:|:.|..|  :.|:.|  |...|::|.||.||
  Fly  1349 EMLIKWLALGFKV----YFTNAWCWLDFVIVMVSLINFVAS--LVGAGG--IQAFKTMRTLRALR 1405

  Rat  1281 PLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFFYCTDESKELERDC 1345
            ||:.:.|:..::.|.:.:|.::.::.|:|:|.::|..|||::.||||.||:|.|        .|.
  Fly  1406 PLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKC--------EDM 1462

  Rat  1346 RGQYLDYE----KEEVEAQPRQWKKYDFHYDNVLWALLTLFTVSTGEGWPMVLKHSVDATYEEQG 1406
            .|..|.:|    :...|::...|.....::|:|..|.|.||.|:|.:||..::..::|:...::.
  Fly  1463 NGTKLSHEIIPNRNACESENYTWVNSAMNFDHVGNAYLCLFQVATFKGWIQIMNDAIDSREVDKQ 1527

  Rat  1407 PSPGFRMELSIF---YVVYFVVF-PFFFVNIFVALIIITFQEQGDKVMSECSL-----EKNERAC 1462
            |.    .|.:|:   |.|:|::| .||.:|:|:.:||..|.||..|......:     :|.....
  Fly  1528 PI----RETNIYMYLYFVFFIIFGSFFTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNA 1588

  Rat  1463 IDFAISAKPLTRYMPQNKQSFQYKTWTFVVSPPFEYFIMAMIALNTVVLMMKFYDAPYEYELMLK 1527
            :....|.||| :.:|:.:...|...:..|....|:..||..|.||...:.:..|||...|..:|.
  Fly  1589 MKKMGSKKPL-KAIPRPRWRPQAIVFEIVTDKKFDIIIMLFIGLNMFTMTLDRYDASDTYNAVLD 1652

  Rat  1528 CLNIVFTSMFSLECILKIIAFGVLNYFRDAWNVFDFVTVLGSITDILVTEIAETNNFINLSFLRL 1592
            .||.:|..:||.||:|||.|.. .:||.:.||:||.|.|:.||..:::::|.| ..|::.:.||:
  Fly  1653 YLNAIFVVIFSSECLLKIFALR-YHYFIEPWNLFDVVVVILSILGLVLSDIIE-KYFVSPTLLRV 1715

  Rat  1593 FRAA---RLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIALDDGTS 1654
            .|.|   |:::|::....||.||:....|..||..:|||:.::.||:||.||..|.::....|  
  Fly  1716 VRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKEKSG-- 1778

  Rat  1655 INRHNNFRTFLQALMLLFRSATGEAWHEIMLSCLGNRACDPHAN----ASECGS-DFAYFYFVSF 1714
            ||...||:||.|:::|||:.:|...|..::.:.:...||||..|    ...||| .....:.:|:
  Fly  1779 INDVYNFKTFGQSMILLFQMSTSAGWDGVLDAIINEEACDPPDNDKGYPGNCGSATVGITFLLSY 1843

  Rat  1715 IFLCSFLMLNLFVAVIMDNFEYLTRD-SSILGPHHLDEFIRVWAEYDPAACGRISYNDMFEMLKH 1778
            :.:...:::|:::|||::|:...|.| ...|.....|.:..:|.::||.....|.|:.:.|.|..
  Fly  1844 LVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQQFDPEGTQYIRYDQLSEFLDV 1908

  Rat  1779 MSPPLGLGKKCPARVAYKRLVRMNMPISNEDMTVHFTSTLMALIRTALEIKLAP------AGTKQ 1837
            :.|||.:.|  |.:  || ::.|::||...|: ::....|.||.:.....|..|      .|...
  Fly  1909 LEPPLQIHK--PNK--YK-IISMDIPICRGDL-MYCVDILDALTKDFFARKGNPIEETGEIGEIA 1967

  Rat  1838 HQCDAELRKEISS-VWANLPQKTLDLLVPPHKPDEMTVGKVYAALMIFDFYKQNKTTRD------ 1895
            .:.|.|..:.:|| :|....:                    |.|.:|...::::|...:      
  Fly  1968 ARPDTEGYEPVSSTLWRQREE--------------------YCARLIQHAWRKHKARGEGGGSFE 2012

  Rat  1896 -QTHQAPGGLSQMGPVSLFHPLKATLEQTQPAVLRGARVFLRQKSATSLSNG---GAIQTQESGI 1956
             .|....||....|..:   |.:|| :...||...|:            .||   ||....||.:
  Fly  2013 PDTDHGDGGDPDAGDPA---PDEAT-DGDAPAGGDGS------------VNGTAEGAADADESNV 2061

  Rat  1957 KESLSWGTQRTQDVLYEARAPLERGHSAEIPVGQPGA-----------------------LAVDV 1998
            ...       .:|....|.|......:.....|.|||                       :.:..
  Fly  2062 NSP-------GEDAAAAAAAAAAAAAAGTTTAGSPGAGSAGRQTAVLVESDGFVTKNGHKVVIHS 2119

  Rat  1999 QMQNMTLRGPD--GEPQPGLE 2017
            :..::|.|..|  ..|:|.|:
  Fly  2120 RSPSITSRTADVXARPRPPLQ 2140

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cacna1bXP_006233631.1 Ion_trans 112..367 CDD:278921 93/287 (32%)
Ion_trans 500..721 CDD:278921 76/237 (32%)
Ion_trans 1186..1448 CDD:278921 92/275 (33%)
Ion_trans 1511..1742 CDD:278921 81/239 (34%)
GPHH 1750..1814 CDD:293510 19/63 (30%)
Ca_chan_IQ 1816..1890 CDD:285917 14/80 (18%)
paraNP_001259619.1 Ion_trans 165..436 CDD:278921 93/282 (33%)
Na_trans_cytopl 515..648 CDD:288761 4/132 (3%)
Ion_trans 835..1028 CDD:278921 67/210 (32%)
Na_trans_assoc 1054..1296 CDD:284034 65/473 (14%)
Ion_trans 1318..1571 CDD:278921 93/277 (34%)
Na_channel_gate 1561..1613 CDD:240441 11/52 (21%)
Ion_trans 1636..1871 CDD:278921 81/238 (34%)
GPHH 1880..1930 CDD:293510 16/54 (30%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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