DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Myh9 and didum

DIOPT Version :9

Sequence 1:NP_037326.2 Gene:Myh9 / 25745 RGDID:3140 Length:1960 Species:Rattus norvegicus
Sequence 2:NP_724569.1 Gene:didum / 35680 FlyBaseID:FBgn0261397 Length:1800 Species:Drosophila melanogaster


Alignment Length:1937 Identity:523/1937 - (27%)
Similarity:881/1937 - (45%) Gaps:355/1937 - (18%)


- Green bases have known domain annotations that are detailed below.


  Rat    32 VWVPSTKNGFEPASLKEEV--GEEAIVELVENGK----KVKVNKDDIQKM-NPPKFSKVEDMAEL 89
            :|||.....:|.|:|:|..  |...:....::||    |:|.:..|:..: ||.......|:..|
  Fly    14 IWVPHADLVWESATLEESYRKGAGFLKICTDSGKLKEVKLKADGSDLPPLRNPAILVGQNDLTTL 78

  Rat    90 TCLNEASVLHNLKERYYS-GLIYTYSGLFCVVINPYKNLPIYSEEIVDMYKGKKRHEMPPHIYAI 153
            :.|:|..|||||:.|:.. .:||||.|:..|.||||..:|:|...|:..|:|....::.|||:|:
  Fly    79 SYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYRGHAMGDLEPHIFAL 143

  Rat   154 TDTAYRSMMQDREDQSILCTGESGAGKTENTKKVIQYLAHVASSHKSKKDQGELERQLLQANPIL 218
            .:.||..:.::..:.||:.:||||||||.:.|..::|.|.|..|    :.:.::||::|.::||:
  Fly   144 AEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGGS----ESETQVERKVLASSPIM 204

  Rat   219 EAFGNAKTVKNDNSSRFGKFIRINF-DVNG--YIVGANIETYLLEKSRAIRQAKEERTFHIFYYL 280
            ||||||||.:||||||||||.::.| :..|  ::.||.:.||||||||.:.||:.||.:||||.|
  Fly   205 EAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQGERNYHIFYQL 269

  Rat   281 LSGAGEHLKTDLLLEPYNKYRFLS-NGHVTIPGQQDKDMFQETMEAMRIMGIPEDEQMGLLRVIS 344
            .:...::  .:|:|:..:|::||: .|...|....|.:.|.||::||.::|....:...::::::
  Fly   270 CAARSKY--PELVLDHQDKFQFLNMGGAPEIERVSDAEQFNETVQAMTVLGFSIQQIADIVKILA 332

  Rat   345 GVLQLGNI-VFKK------ERNTDQASMPDNTA-AQKVSHLLGINVTDFTRGILTPRIKVGRDYV 401
            |:|.|||| |.||      |.::|...:..|.. .|..:.||.::..|..|.:|..:|:...:||
  Fly   333 GILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQITADLLRVSADDLRRWLLMRKIESVNEYV 397

  Rat   402 QKAQTKEQADFAIEALAKATYERMFRWLVLRINKALDKTKRQGASFIGILDIAGFEIFDLNSFEQ 466
            ....:.|.|..|.:||||..|.::|:::|..:||:|:...:| .||||:|||.|||.|::|||||
  Fly   398 LIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLNNGSKQ-CSFIGVLDIYGFETFEVNSFEQ 461

  Rat   467 LCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIDLIEKPAGPPGILALLDEE 531
            .||||.||||||.||..:|.||||||.:|||.|..||| .|.||||||||...   |:|.|||||
  Fly   462 FCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDF-YDNQPCIDLIESRL---GVLDLLDEE 522

  Rat   532 CWFPKATDKSFVEKVVQEQGTHPKFQKPKQLKDKADFCIIHYAGKVDYKADEWLMKNMDPLNDNI 596
            |..||.:|:|:..|::.:....|.|:||:  .....|.|.|::..|:|..:.:|.||.|.::..:
  Fly   523 CRMPKGSDESWAGKLIGKCNKFPHFEKPR--FGTTSFFIKHFSDTVEYDVNGFLEKNRDTVSKEL 585

  Rat   597 ATLLHQSSDKFVSELW--KDVDRIIGLDQVAGMSETALPGAF-----------KTRKGMF----- 643
            ..:|.:|:.....::.  :::|.:.    |.....:.|.|..           .||:.:.     
  Fly   586 TQVLSESNMSLAKQVMTLEEIDTLC----VDSAKSSTLGGRVVISAGRKQQGNDTRRRVVPSKQH 646

  Rat   644 -RTVGQLYKEQLAKLMATLRNTNPNFVRCIIPNHEKKAGKLDPHLVLDQLRCNGVLEGIRICRQG 707
             :|||..::|.||.|::||..|.|::||||.||.:|.|.|.:...::.|||..||||.:||...|
  Fly   647 RKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACGVLETVRISAAG 711

  Rat   708 FPNRVVFQEFRQRYEILTPNS-IPKGFMDGKQACVLMIKALELDSNLYRIGQSKVFFRAGVLAHL 771
            ||:|.::.:|..||::|...| :.|.  |.|.:|..::.....|.:.||.|.:::|||||.:|.|
  Fly   712 FPSRWLYPDFYMRYQLLVYRSKLDKN--DMKLSCRNIVMKWIQDEDKYRFGNTQIFFRAGQVAFL 774

  Rat   772 EEERD-----------------------LKITDVIIGFQACCRGYLARKAFAKRQQQLTAMKVLQ 813
            |:.|.                       |:|..||.|.|...||||||:. .::.::..|..:|.
  Fly   775 EQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQKHARGYLARER-TQKMREARAGLILS 838

  Rat   814 RNCAAYLRLRNWQWWRLFTKVKPLLNSIR-HEDELLAKEAELTKVREKHLAAENRLTEMETMQSQ 877
            :..      |.|...|.:.:::..::.|: :...:||        |.|..|..:....::..:..
  Fly   839 KYA------RGWLCRRRYLRLRHSISGIQTYARGMLA--------RNKFHAMRDHYRAVQIQRFV 889

  Rat   878 LMAEKLQLQEQLQAETELCAEAEE---LRARLTAKKQELEEICHDLEARVEEEEERCQYLQAEKK 939
            ..|...:..::.:....:|..|..   .|.:....|.|.:.|.|     :|.     :|:..|.|
  Fly   890 RGALARRAYQKRRRNIIICQAAIRRFLARRKFKRMKAEAKTISH-----MEN-----KYMGLENK 944

  Rat   940 --KMQQNIQE-------LEEQLEEEESARQKLQLEKVTTEAKLKKLEEDQIIMEDQNCKLAKEKK 995
              .|||.|.|       |:.:..|....:.||:|:| |.||:.|            |.|.|.:.|
  Fly   945 IISMQQRIDELNRDNSNLKHKTSEISVLKMKLELKK-TLEAEFK------------NVKAACQDK 996

  Rat   996 LLEDRVAEFTTNLMEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDL 1060
               |::.|.....:|.|...|.....:|.|..     ||.:.:::..|||.|:.||::       
  Fly   997 ---DKLIEALNKQLEAERDEKMQLLEENGHAQ-----EEWISQKQTWRQENEELRRQI------- 1046

  Rat  1061 SDQIAELQAQIAELKMQLAKKEEELQAALARVE-EEAAQKNMALKKIRELETQISELQEDLE--- 1121
             |:|.:: |:.||:..:  .:|:.:.|.:...| .||.|:  |:|....:|.:...|:|:|.   
  Fly  1047 -DEIIDM-AKNAEVNQR--NQEDRMLAEIDNRELNEAYQR--AIKDKEVIENENFMLKEELSRLT 1105

  Rat  1122 ------SERACRNKAEKQKRDLGEELEALKTELE-----DTL-------DSTAAQQELRSKREQE 1168
                  ..|...|.:.:.:.|:|  ..:.|..|:     |.|       |||:...:|||..|:|
  Fly  1106 AGSFSLHARKASNASSQNEDDVG--YASAKNTLDINRPPDLLSKNYSYNDSTSLVVKLRSILEEE 1168

  Rat  1169 -------------VSILKKTLEDEAKT----------------------HEAQIQEMRQKHSQAV 1198
                         :|...|..||..:.                      |..:|.|:..:|:...
  Fly  1169 KQKHKVLQEQYIKLSSRHKPTEDSFRVSELEVENEKLRSEYDQLRTSIKHGVEINELNAQHAALQ 1233

  Rat  1199 EELAEQLEQTKRVKATL---EKAKQTLENERGEL-ANEVKALLQGKGDSEHKRKKVEAQLQ-ELQ 1258
            ||:..:.|:..::||.|   .::.::||.|..:: .|:|..|:    ::.|.:|.:..||: ||:
  Fly  1234 EEVRRRREECIQLKAVLLQQSQSMRSLEPESLQMRGNDVNELM----EAFHSQKLINRQLESELK 1294

  Rat  1259 VKFSEGERVRTELADKVSKLQVELDSVTGLLNQS-----DSKSSKLTKDFSALESQLQDTQE--- 1315
            ....|......|:..::.:|..|.|.:..::.:|     ||....|.::...|..:||....   
  Fly  1295 AITEEHNSKLVEMTQEIERLNNEKDELQKVMFESIDEFEDSNVDTLRQNDRYLRRELQKAVAQFL 1359

  Rat  1316 LLQEENRQKLSLSTKLKQMEDEKNSFREQLEEEEEAKRNLEKQIATLHAQVTDMKKKMEDGVGCL 1380
            |:|||  .||: :.|||....:......:: |||..:.......|.:.|.||..|.:...|:...
  Fly  1360 LVQEE--LKLA-NAKLKAYRQDGGQLEHKI-EEEMIRNKSNGTSADVGANVTKQKSQNPQGLMKF 1420

  Rat  1381 ETAEEAKRRLQKDLEGLSQRLEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSVSNLEKKQKK 1445
            .::         ||:.:.|||...:.     .:|...|.......|:.:..:...::|.:.    
  Fly  1421 HSS---------DLDKILQRLLSALT-----PRTVVGLLPGFPAYLIFMCIRYTDLTNADD---- 1467

  Rat  1446 FDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARA--LEEAMEQKAELERLNKQFRTEMED 1508
                  :.:.:.:|:..:..:........|.:.:.|..:  |...|:|..:::...| |.||.::
  Fly  1468 ------DVRELLSKFVIQIKKMHRTPHPIENRVIWLVNSITLLNLMKQYGDVDEYVK-FNTEKQN 1525

  Rat  1509 LMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDL 1573
            ....|:      ..|.:.:|.:...:..:   .:.|..::|...|.|:   |.......:.:|..
  Fly  1526 QQQLKN------FNLFEYRRVILDLIVNL---YQALIMQIQGLLDPKI---VPAILNNDEIQRGR 1578

  Rat  1574 QGRDEQSEEKK---------------KQLVRQVREMEAELEDERKQRSIAMAARKKLEMDLKDLE 1623
            |....:|....               |||:.|:.....:.:                        
  Fly  1579 QAHGMRSRATSIGASSSPEHGGGPAWKQLIGQLEHFYKQFQ------------------------ 1619

  Rat  1624 AHIDTANKNREEAIKQ---------LRKLQAQMKDCMRE-----------LDD----TRASREEI 1664
             |....|...|:...|         |..|..:...||.|           ::|    .:.|.:.:
  Fly  1620 -HFGLDNCYAEQIFHQLLYFICAVALNCLMLRGDICMWETGMIIRYNIGCIEDWVRSKKMSNDVL 1683

  Rat  1665 LAQAKENE--KKLKSMEAE-----MIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALE 1722
            .|.|..|:  :.|:|.::|     :..|...|:.|:..|.....:.|:...||.|      :.||
  Fly  1684 TALAPLNQVSQLLQSRKSEQDVQTICDLCTSLSTAQVLKVMKSYKLDDYESEITN------VFLE 1742

  Rat  1723 E-KRRLEARIAQL--EEELEEEQGNTELINDRLKKANLQIDQIN--TDLNLE 1769
            : ..:|.||..|.  .:|...:|...:......:.::::::.|.  :.|||:
  Fly  1743 KLTEKLNARQMQKSNSDEFTIDQKFIQPFKVVFRYSDIKLEDIELPSHLNLD 1794

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myh9NP_037326.2 Myosin_N 29..68 CDD:397036 12/41 (29%)
Motor_domain 95..764 CDD:419868 267/701 (38%)
Myosin_tail_1 842..1921 CDD:396244 211/1064 (20%)
didumNP_724569.1 MYSc 65..778 CDD:214580 280/731 (38%)
MYSc_Myo5 84..767 CDD:276831 267/701 (38%)
IQ 900..922 CDD:197470 3/21 (14%)
GBP_C <971..1086 CDD:303769 39/148 (26%)
coiled coil 1049..1068 CDD:293879 5/21 (24%)
coiled coil 1077..1086 CDD:293879 4/10 (40%)
JAKMIP_CC3 <1190..1299 CDD:292653 24/112 (21%)
Myo5_CBD 1424..1792 CDD:271254 68/426 (16%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.910

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