DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Myh9 and Mhc

DIOPT Version :9

Sequence 1:NP_037326.2 Gene:Myh9 / 25745 RGDID:3140 Length:1960 Species:Rattus norvegicus
Sequence 2:NP_001162991.1 Gene:Mhc / 35007 FlyBaseID:FBgn0264695 Length:1962 Species:Drosophila melanogaster


Alignment Length:1915 Identity:783/1915 - (40%)
Similarity:1172/1915 - (61%) Gaps:36/1915 - (1%)


- Green bases have known domain annotations that are detailed below.


  Rat    28 AKKLVWVPSTKNGFEPASLKEEVGEEAIVELVENGKKVKVNKDDIQKMNPPKFSKVEDMAELTCL 92
            :||..|:|..|.|:....:|...|:...|.| :.|:...:..:.::|:|||||.|:||||::|.|
  Fly    34 SKKSCWIPDEKEGYLLGEIKATKGDIVSVGL-QGGEVRDIKSEKVEKVNPPKFEKIEDMADMTVL 97

  Rat    93 NEASVLHNLKERYYSGLIYTYSGLFCVVINPYKNLPIYSEEIVDMYKGKKRHEMPPHIYAITDTA 157
            |...|||||::|||:.|||||||||||.|||||..|:|:.....||:||:|:|:||||:||:|.|
  Fly    98 NTPCVLHNLRQRYYAKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYRGKRRNEVPPHIFAISDGA 162

  Rat   158 YRSMMQDREDQSILCTGESGAGKTENTKKVIQYLAHVASSHK---SKKDQGELERQLLQANPILE 219
            |..|:.:..:||:|.||||||||||||||||.|.|.|.:|.|   :.|.:|.||.|::|.||:||
  Fly   163 YVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGASKKTDEAAKSKGSLEDQVVQTNPVLE 227

  Rat   220 AFGNAKTVKNDNSSRFGKFIRINFDVNGYIVGANIETYLLEKSRAIRQAKEERTFHIFYYLLSGA 284
            ||||||||:|||||||||||||:|...|.:.||:||||||||:|.|.|...||::||||.::||:
  Fly   228 AFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQSLERSYHIFYQIMSGS 292

  Rat   285 GEHLK-TDLLLEPYNKYRFLSNGHVTIPGQQDKDMFQETMEAMRIMGIPEDEQMGLLRVISGVLQ 348
            ...:| ..||.:....|..:|.|.||:....|.:.|..|.:|..|:|..:.|:..:.|:.:.|:.
  Fly   293 VPGVKDICLLTDNIYDYHIVSQGKVTVASIDDAEEFSLTDQAFDILGFTKQEKEDVYRITAAVMH 357

  Rat   349 LGNIVFKKERNTDQASMPDNTAAQKVSHLLGINVTDFTRGILTPRIKVGRDYVQKAQTKEQADFA 413
            :|.:.||:....:||.........:||.|.|.:..:..:.:|.||||||.::|.:.:..:|...:
  Fly   358 MGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCDTAELYKNLLKPRIKVGNEFVTQGRNVQQVTNS 422

  Rat   414 IEALAKATYERMFRWLVLRINKALDKTKRQGASFIGILDIAGFEIFDLNSFEQLCINYTNEKLQQ 478
            |.||.|..::|:|:|||.:.|:.|| |:::...|||:|||||||||:.|.|||||||:|||||||
  Fly   423 IGALCKGVFDRLFKWLVKKCNETLD-TQQKRQHFIGVLDIAGFEIFEYNGFEQLCINFTNEKLQQ 486

  Rat   479 LFNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIDLIEKPAGPPGILALLDEECWFPKATDKSFV 543
            .|||.||:||||||:||||:|.|||||:||..||||||||.   |||::|:||..||||||::|.
  Fly   487 FFNHHMFVLEQEEYKREGIDWAFIDFGMDLLACIDLIEKPM---GILSILEEESMFPKATDQTFS 548

  Rat   544 EKVVQEQ-GTHPKFQKPKQLK---DKADFCIIHYAGKVDYKADEWLMKNMDPLNDNIATLLHQSS 604
            ||:.... |....|||||..|   ..|.|.|.||||.|.|....||.||.|||||.:.....:|.
  Fly   549 EKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITGWLEKNKDPLNDTVVDQFKKSQ 613

  Rat   605 DKFVSELWKDVDRIIGLDQVAGMS---ETALPGAFKTRKGMFRTVGQLYKEQLAKLMATLRNTNP 666
            :|.:.|::.|         .||.|   |.|..|..| :.|.|.||...|||||..||.|||:|.|
  Fly   614 NKLLIEIFAD---------HAGQSGGGEQAKGGRGK-KGGGFATVSSAYKEQLNSLMTTLRSTQP 668

  Rat   667 NFVRCIIPNHEKKAGKLDPHLVLDQLRCNGVLEGIRICRQGFPNRVVFQEFRQRYEILTPNSIPK 731
            :||||||||..|:.|.:|.|||:.||.||||||||||||:|||||:::.:|:.||:|:.|..: :
  Fly   669 HFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYKIMCPKLL-Q 732

  Rat   732 GFMDGKQACVLMIKALELDSNLYRIGQSKVFFRAGVLAHLEEERDLKITDVIIGFQACCRGYLAR 796
            |....|:|..::||.::|..:.||:|.:|||||||||..:||.||.::..::...||..||||:|
  Fly   733 GVEKDKKATEIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERLGKIMSWMQAWARGYLSR 797

  Rat   797 KAFAKRQQQLTAMKVLQRNCAAYLRLRNWQWWRLFTKVKPLLNSIRHEDELLAKEAELTKVREKH 861
            |.|.|.|:|..|:||:|||...||:||.|.|::|:.|||||||..|.|||:...|.:..|..|.|
  Fly   798 KGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRIEDEIARLEEKAKKAEELH 862

  Rat   862 LAAENRLTEMETMQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEE 926
            .|......|:|.:.::|:|||..|.:.|..|.....:.:|..|:|||:|.:||....|::.|:.:
  Fly   863 AAEVKVRKELEALNAKLLAEKTALLDSLSGEKGALQDYQERNAKLTAQKNDLENQLRDIQERLTQ 927

  Rat   927 EEERCQYLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEDQIIMEDQNC-KL 990
            ||:....|..:|||..|.|..|::.:|:.|...||.:.:|.|.:.:::.| .|:|..:|:.. ||
  Fly   928 EEDARNQLFQQKKKADQEISGLKKDIEDLELNVQKAEQDKATKDHQIRNL-NDEIAHQDELINKL 991

  Rat   991 AKEKKLLEDRVAEFTTNLMEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEG 1055
            .||||:..:...:....|...|:|...|.|:|.|.|..:.:||:.|.||:|.|.::||::||:||
  Fly   992 NKEKKMQGETNQKTGEELQAAEDKINHLNKVKAKLEQTLDELEDSLEREKKVRGDVEKSKRKVEG 1056

  Rat  1056 DSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELETQISELQEDL 1120
            |.....:.:|:|:....||:..:.:|::||.:..|::|:|........::|:||:.:|.||:|::
  Fly  1057 DLKLTQEAVADLERNKKELEQTIQRKDKELSSITAKLEDEQVVVLKHQRQIKELQARIEELEEEV 1121

  Rat  1121 ESERACRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVSILKKTLEDEAKTHEA 1185
            |:||..|.|||||:.||..|||.|...||:...:|:||.||..|||.|:|.|::.||:....||:
  Fly  1122 EAERQARAKAEKQRADLARELEELGERLEEAGGATSAQIELNKKREAELSKLRRDLEEANIQHES 1186

  Rat  1186 QIQEMRQKHSQAVEELAEQLEQTKRVKATLEKAKQTLENERGELANEVKALLQGKGDSEHKRKKV 1250
            .:..:|:||:.||.|:|||::|..::||..||.|.....:..:|...|..:...|...|...|::
  Fly  1187 TLANLRKKHNDAVAEMAEQVDQLNKLKAKAEKEKNEYYGQLNDLRAGVDHITNEKAAQEKIAKQL 1251

  Rat  1251 EAQLQELQVKFSEGERVRTELADKVSKLQVELDSVTGLLNQSDSKSSKLTKDFSALESQLQDTQE 1315
            :..|.|:|.|..|..|...:......||.:|...:...|.:::|:.|:|:|...:|.:||:||:.
  Fly  1252 QHTLNEVQSKLDETNRTLNDFDASKKKLSIENSDLLRQLEEAESQVSQLSKIKISLTTQLEDTKR 1316

  Rat  1316 LLQEENRQKLSLSTKLKQMEDEKNSFREQLEEEEEAKRNLEKQIATLHAQVTDMKKKME-DGVGC 1379
            |..||:|::.:|..|.:.:|.:.::.|||:|||.|.|.:|::|::..:|:....:.|.| |||..
  Fly  1317 LADEESRERATLLGKFRNLEHDLDNLREQVEEEAEGKADLQRQLSKANAEAQVWRSKYESDGVAR 1381

  Rat  1380 LETAEEAKRRLQKDLEGLSQRLEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSVSNLEKKQK 1444
            .|..|||||:||..|....:.:|........|||||.||..|::||.:::|......:..|||||
  Fly  1382 SEELEEAKRKLQARLAEAEETIESLNQKCIGLEKTKQRLSTEVEDLQLEVDRANAIANAAEKKQK 1446

  Rat  1445 KFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDL 1509
            .||:::.|.|......|.|.|.::.|.|...|:...|..|.||..||...:.|.||....|::||
  Fly  1447 AFDKIIGEWKLKVDDLAAELDASQKECRNYSTELFRLKGAYEEGQEQLEAVRRENKNLADEVKDL 1511

  Rat  1510 MSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQ 1574
            :....:.|:::||:||:::.||.:.:|::..|||.|..|:..|:..||.::.|..::.:.:|.:|
  Fly  1512 LDQIGEGGRNIHEIEKARKRLEAEKDELQAALEEAEAALEQEENKVLRAQLELSQVRQEIDRRIQ 1576

  Rat  1575 GRDEQSEEKKKQLVRQVREMEAELEDERKQRSIAMAARKKLEMDLKDLEAHIDTANKNREEAIKQ 1639
            .::|:.|..:|...|.:..|:|.||.|.|.::.|:..:||||.|:.:||..:|.|||...||.|.
  Fly  1577 EKEEEFENTRKNHQRALDSMQASLEAEAKGKAEALRMKKKLEADINELEIALDHANKANAEAQKN 1641

  Rat  1640 LRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERD 1704
            :::.|.|:||....|::.:.:|::...|...:|::..:::.|:.:.:..|..|:|.:|||:||..
  Fly  1642 IKRYQQQLKDIQTALEEEQRARDDAREQLGISERRANALQNELEESRTLLEQADRGRRQAEQELA 1706

  Rat  1705 ELADEIANSSGKGALALEEKRRLEARIAQLEEELEE---EQGNTELINDRLKKANLQIDQINTDL 1766
            :..:::...|.:.|.....||:||:.:..|..:|:|   |..|:|   ::.|||.:...::..:|
  Fly  1707 DAHEQLNEVSAQNASISAAKRKLESELQTLHSDLDELLNEAKNSE---EKAKKAMVDAARLADEL 1768

  Rat  1767 NLERSHAQKNENARQQLERQNKELKAKLQEMESAVKSKYKASIAALEAKIAQLEEQLDNETKERQ 1831
            ..|:.|||..|..|:.||:|.|||:.:|.|.|:......|.:|..||.::.:||.:||.|.:...
  Fly  1769 RAEQDHAQTQEKLRKALEQQIKELQVRLDEAEANALKGGKKAIQKLEQRVRELENELDGEQRRHA 1833

  Rat  1832 AASKQVRRAEKKLKDVLLQVEDERRNAEQFKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKL 1896
            .|.|.:|::|:::|::..|.|::|:|.|:.:|..||...::|..|||:|||||.|....|..||.
  Fly  1834 DAQKNLRKSERRVKELSFQSEEDRKNHERMQDLVDKLQQKIKTYKRQIEEAEEIAALNLAKFRKA 1898

  Rat  1897 QRELEDATETADAMNREVSSLKNKLRRGDM 1926
            |:|||:|.|.||...:.:|..:.|.|.|.:
  Fly  1899 QQELEEAEERADLAEQAISKFRAKGRAGSV 1928

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myh9NP_037326.2 Myosin_N 29..68 CDD:397036 11/38 (29%)
Motor_domain 95..764 CDD:419868 343/679 (51%)
Myosin_tail_1 842..1921 CDD:396244 370/1083 (34%)
MhcNP_001162991.1 Myosin_N 36..73 CDD:280832 10/37 (27%)
MYSc 81..777 CDD:214580 364/710 (51%)
MYSc_Myh1_insects_crustaceans 100..765 CDD:276874 343/679 (51%)
Myosin_tail_1 842..1897 CDD:279860 359/1058 (34%)
V_Alix_like 1557..1877 CDD:187408 101/322 (31%)
ATP-synt_B <1671..1771 CDD:304375 26/102 (25%)
TMPIT 1739..>1825 CDD:285135 30/88 (34%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0161
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D47111at2759
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100110
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X58
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
76.720

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