DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Myh9 and ck

DIOPT Version :9

Sequence 1:NP_037326.2 Gene:Myh9 / 25745 RGDID:3140 Length:1960 Species:Rattus norvegicus
Sequence 2:NP_001285949.1 Gene:ck / 34882 FlyBaseID:FBgn0000317 Length:2167 Species:Drosophila melanogaster


Alignment Length:2178 Identity:544/2178 - (24%)
Similarity:898/2178 - (41%) Gaps:526/2178 - (24%)


- Green bases have known domain annotations that are detailed below.


  Rat    32 VWVPSTKNGFEPASLKE-EVGEEAIVELVENGKKVKVNKDD-----------IQKMNPPKFSKVE 84
            :|:       ||||.:| :|...|.|...| |::::|..||           |:.|:......||
  Fly    10 IWI-------EPASGREFDVAIGARVVSAE-GRRIQVRDDDGDEVWLAPERRIKAMHASSVQGVE 66

  Rat    85 DMAELTCLNEASVLHNLKERYYSGLIYTYSGLFCVVINPYKNLPIYSEEIVDMYKGKKRHEMPPH 149
            ||..|..|:||.:|.||..||...|||||:|...|.:|||:.||||:.:.:.:||.:|..|:|||
  Fly    67 DMISLGDLHEAGILRNLLIRYKENLIYTYTGSILVAVNPYQILPIYTGDQIKLYKERKIGELPPH 131

  Rat   150 IYAITDTAYRSMMQDREDQSILCTGESGAGKTENTKKVIQYLAHVASSHKSKKDQGELERQLLQA 214
            |:||.|.||..|.:.|:||.|:.:|||||||||:||.::||||.::..|      ..:|:|:|:|
  Fly   132 IFAIGDNAYAHMKRYRQDQCIVISGESGAGKTESTKLILQYLAAISGKH------SWIEQQILEA 190

  Rat   215 NPILEAFGNAKTVKNDNSSRFGKFIRINFDVNGYIVGANIETYLLEKSRAIRQAKEERTFHIFYY 279
            ||||||||||||::|||||||||:|.|:|..||.|.||.||.|||||||.:.|...||.:|:||.
  Fly   191 NPILEAFGNAKTIRNDNSSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHSERNYHVFYC 255

  Rat   280 LLSGAGEHLKTDLLLEPYNKYRFLSNGH-VTIPGQQDKDMFQETMEAMRIMGIPEDEQMGLLRVI 343
            :|:|.....|:.|.|.....|::|:.|: :|..|:.|...|.:...||:::...:.|...:::::
  Fly   256 ILAGLSADEKSRLDLGMAADYKYLTGGNSITCEGRDDAAEFSDIRSAMKVLLFSDQEIWEIIKLL 320

  Rat   344 SGVLQLGNIVFKKE--RNTDQASMPDNTAAQKVSHLLGINVTDFTRGILTPRIKVGRDYVQKAQT 406
            :.:|..|||.:|..  .|.|...:|::...::|:.|||:.:......:....:....:.|....:
  Fly   321 AALLHCGNIKYKATVVDNLDATEIPEHINVERVAGLLGLPIQPLIDALTRRTLFAHGETVVSTLS 385

  Rat   407 KEQADFAIEALAKATYERMFRWLVLRINKALDKTKRQGASFIGILDIAGFEIFDLNSFEQLCINY 471
            ::|:....:|..|..|.|||..:|.:||.|:.|.:....:.||:|||.|||.||.|||||.||||
  Fly   386 RDQSVDVRDAFVKGIYGRMFVHIVRKINTAIFKPRGTSRNAIGVLDIFGFENFDQNSFEQFCINY 450

  Rat   472 TNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIDLIEKPAGPPGILALLDEECWFPK 536
            .||.|||.|...:|.||||||..|.|.|..|:| :|.|..:|||  ......|:||:|||..|||
  Fly   451 ANENLQQFFVQHIFKLEQEEYNHEAINWQHIEF-VDNQDALDLI--AIKQLNIMALIDEEARFPK 512

  Rat   537 ATDKSFVEKVVQEQGTHPKFQKPKQLKDKADFCIIHYAGKVDYKADEWLMKNMDPLNDNIATLLH 601
            .||::.:.|:.:..|:|..:.|||. .....|.:.|:||.|.|....:|.||.|..:.::..|:.
  Fly   513 GTDQTMLAKLHKTHGSHKNYLKPKS-DINTSFGLNHFAGVVFYDTRGFLDKNRDTFSPDLLHLVS 576

  Rat   602 QSSDKFVSELW-KDVDRIIGLDQVAGMSETALPGAFKTRKGMFRTVGQLYKEQLAKLMATLRNTN 665
            ||::||:.::: :|::.                || :||| ...|:...:::.|..||.||.:..
  Fly   577 QSTNKFLRQIFAQDIEM----------------GA-ETRK-RTPTLSTQFRKSLDALMKTLSSCQ 623

  Rat   666 PNFVRCIIPNHEKKAGKLDPHLVLDQLRCNGVLEGIRICRQGFPNRVVFQEFRQRYEILTPNSIP 730
            |.|:|||.||..||....|..|...|||.:|::|.|||.|.|:|.|..|:||.:||..|.| .:|
  Fly   624 PFFIRCIKPNELKKPMMFDRGLCCRQLRYSGMMETIRIRRAGYPIRHGFREFVERYRFLIP-GVP 687

  Rat   731 KGFMDGKQACVLMIKALELDSNLYRIGQSKVFFRAGVLAHLEEERDLKITDVIIGFQACCRGYLA 795
            .......||....|.|:.|..:.|::|.:|||.:......||:|||..:|..|:..|...||::.
  Fly   688 PAHRTDCQAATSRICAVVLGKSDYQLGHTKVFLKDAHDLFLEQERDRVLTRKILILQRSIRGWVY 752

  Rat   796 RKAFAKRQQQLTAMKVLQRNCAAYLRLRNWQWWRL-FTKVKPLLNS------IRH-EDELLAKEA 852
            |:.|.:.:   .|...:||....|.:.:.::..|: :.:::.|:.|      .|| ...::..:|
  Fly   753 RRRFLRLR---AAAITVQRFWKGYAQRKRYRNMRVGYMRLQALIRSRVLSHRFRHLRGHIVGLQA 814

  Rat   853 ELT--KVREKH-------LAAENRLTEMETMQSQLMAEKLQLQEQLQAETELCAEAEELRARLTA 908
            ...  .||.::       :..::.:..|..|:..   .||:|:.:..||.            |..
  Fly   815 HARGYLVRREYGHKMWAVIKIQSHVRRMIAMRRY---RKLRLEHKQFAEV------------LQL 864

  Rat   909 KKQELEEICH--DLEAR-VEEEEERCQYLQAEKKKMQQNIQELEEQLEE-----------EESAR 959
            :|.|.:|:.|  :..|| :.|:..|.:..:.|::       |::||||.           .::||
  Fly   865 RKLEEQELLHRGNKHAREIAEQHYRDRLHELERR-------EIQEQLENRRRVEVNMNIINDAAR 922

  Rat   960 QKLQLEKVTTEAKL---------------------------------KKLEEDQI-----IMEDQ 986
            ::   |:...:.||                                 :.:.:|.|     |.|| 
  Fly   923 KQ---EEPVDDGKLVEAMFDFLPDSSSDAPTPHGGRETSVFNDLPHAQNVNQDDIIAPIHISED- 983

  Rat   987 NCKLAKEKKLLEDRVAEFTTNLMEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRR 1051
                  |:.|.|.:..:|..... :...:...||...||..    |....:.::...|.|..|..
  Fly   984 ------EEDLSEFKFQKFAATYF-QGNVNHQYAKKALKHPL----LPLHTQGDQLAAQALWITIL 1037

  Rat  1052 KLEGD-------STDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIREL 1109
            :..||       :.|..|..:.:....|.|.....:.:|..:|.|..::.:|..|    :|.|.:
  Fly  1038 RFTGDMPEPKYHTMDRMDTTSVMSKVTATLGRNFIRSKEFQEAQLMGLDPDAFLK----QKPRSI 1098

  Rat  1110 ETQISELQEDLESERACRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEV----- 1169
            ..::..|             ..|:|..|||::.....:.|.|.||  .|..|:|:....:     
  Fly  1099 RHKLVSL-------------TLKRKNKLGEDVRRRLQDDEYTADS--YQSWLQSRPTSNLEKLHF 1148

  Rat  1170 ----SILKKTLEDEAKTHEAQI------QEMRQKH-------SQAVEELAEQLEQTKRVKATL-- 1215
                .||:..|.||.   ..||      ..::..|       |..|...|...:....::|.:  
  Fly  1149 IIGHGILRAELRDEI---YCQICKQLTNNPLKSSHARGWILLSLCVGCFAPSEKFVNYLRAFIRE 1210

  Rat  1216 ----------EKAKQTLENERGELANEVKALLQGKGDSEHKRKKVEAQLQE------LQVKFSEG 1264
                      |:.|:|..|                |........:|.|..:      |.:.|.:|
  Fly  1211 GPPGYAPYCEERLKRTFNN----------------GTRNQPPSWLELQATKSKKPIMLPITFMDG 1259

  Rat  1265 ERVRTELADKVSKLQVELDSVTGLLNQSD-----------SKSSKLTKDFSALESQLQDTQELLQ 1318
             ..:|.|||..:..:...:.::..::..|           .|.|.|......:...:...::..:
  Fly  1260 -NTKTLLADSATTARELCNQLSDKISLKDQFGFSLYIALFDKVSSLGSGGDHVMDAISQCEQYAK 1323

  Rat  1319 EENRQKLSLSTKLKQMEDEKNSFREQL------EEEEEAKRNL------------------EKQI 1359
            |:..|:.:...:|        .||:::      ...::...||                  |:.:
  Fly  1324 EQGAQERNAPWRL--------FFRKEIFAPWHEPTHDQVATNLIYQQVVRGVKFGEYRCDKEEDL 1380

  Rat  1360 ATLHAQ------VTDMKKK---------MEDGVGCLETAEEAKRR-----LQ--------KDLEG 1396
            |.:.||      .|||..:         :.|  .||...::|..|     ||        || :.
  Fly  1381 AMIAAQQYFIEYSTDMSMERLFTLLPNFIPD--FCLSGVDKAIERWAALVLQAYKKSYYVKD-KI 1442

  Rat  1397 LSQRLEEKVAAYDK--------------------LEK---------TKTRLQQELDDLLVDLDHQ 1432
            ...:::|.:.:|.|                    |.|         |...:..:.:.:|::|...
  Fly  1443 APLKIKEDIVSYAKYKWPLLFSRFYEAYRNSGPNLPKNDVIIAVNWTGVYVVDDQEQVLLELSFP 1507

  Rat  1433 RQSVSNLEKKQKKFDQLLA------EEKTISAKYAEE-RDRA-----EAEAREKETKALSLARAL 1485
            ..:..:.:|..|.|.|..:      ||.|..:..||: ||..     ..:.|.|...||...||.
  Fly  1508 EITAVSSQKTNKVFTQTFSLSTVRGEEFTFQSPNAEDIRDLVVYFLDGLKKRSKYVIALQDYRAP 1572

  Rat  1486 EEAME----QKAELERLNKQ------------------------FRTE----MEDLMSSKDDVGK 1518
            .:...    .|.:|..|..:                        |..|    :..|.....|:..
  Fly  1573 SDGTSFLSFFKGDLIILEDESCGESVLNNGWCIGRCDRSQERGDFPAETVYVLPTLSKPPQDILA 1637

  Rat  1519 --SVHELEKSKR--------ALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQA--------- 1564
              ::.|....:|        |:|.: :...|.:|...|..:......:...:.|.:         
  Fly  1638 LFNIEEAHHGRRLSMASNGGAVEPR-DRPHTLMEYALDHFRLPPKRTMSKTLTLSSKRSEELWRY 1701

  Rat  1565 ----MKAQFERDLQGRDEQSEE-----------------KKKQLVRQVRE--MEAELEDERKQRS 1606
                :||...|.||.::|.:||                 |:.::..::.:  .:..|:.|..:..
  Fly  1702 SRDPIKAPLLRKLQSKEEFAEEACFAFAAILKYMGDLPSKRPRMGNEITDHIFDGPLKHEILRDE 1766

  Rat  1607 IAMAARKKLEMDLKDLEAHIDTANKNR--EEAIKQLRKLQAQMKDC----MRELDDTRASREEIL 1665
            |.....|:|            |.|:||  ||...:|..|...:..|    ::||.....:|...:
  Fly  1767 IYCQLMKQL------------TDNRNRMSEERGWELMWLATGLFACSQGLLKELLLFLRTRRHPI 1819

  Rat  1666 AQ---------AKENEKKLKSMEAEMIQLQE-------------------ELAAAERAKRQAQQE 1702
            :|         .:..::|....:.|:..:|.                   |:.::.|||      
  Fly  1820 SQDSMHRLQKTIRHGQRKYPPHQVEVEAIQHKTTQIFHKVYFPDDTDEAFEVDSSTRAK------ 1878

  Rat  1703 RDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGN-----TELINDRLKKANLQIDQI 1762
                 |...|.|.:.:|...|...|..:||  ::.:...:|:     ...:.|.:|||....|..
  Fly  1879 -----DFCNNISQRLSLRTSEGFSLFVKIA--DKVISVPEGDFFFDFVRHLTDWIKKARPIRDGA 1936

  Rat  1763 NTDLNLE---------RSHAQKNENA------RQQL-------ERQNKELKAKLQEMESAVKSKY 1805
            |.....:         .:...|:.||      .|:|       .:.::|..|||..:  ..:.::
  Fly  1937 NPQFTYQVFFMKKLWTNTVPGKDRNADLIFHYHQELPKLLRGYHKCSREEAAKLAAL--VFRVRF 1999

  Rat  1806 KASIAALEAKIAQLEEQLDNETKERQAASKQVR 1838
            ..:...|:|....|.|.:.::..:.|:.|:..|
  Fly  2000 GENKQELQAIPQMLRELIPSDIMKIQSTSEWKR 2032

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myh9NP_037326.2 Myosin_N 29..68 CDD:397036 11/36 (31%)
Motor_domain 95..764 CDD:419868 269/672 (40%)
Myosin_tail_1 842..1921 CDD:396244 233/1345 (17%)
ckNP_001285949.1 MYSc 64..733 CDD:214580 279/697 (40%)
MYSc_Myo7 77..721 CDD:276832 269/672 (40%)
MyTH4 <1138..1245 CDD:214535 19/125 (15%)
B41 1251..1467 CDD:214604 37/227 (16%)
FERM_B-lobe 1355..1439 CDD:271216 16/85 (19%)
FERM_C1_MyoVII 1461..1559 CDD:270019 16/97 (16%)
SH3 1560..1624 CDD:302595 10/63 (16%)
MyTH4 1701..1849 CDD:214535 29/159 (18%)
B41 1856..2068 CDD:214604 35/192 (18%)
FERM_M 1966..2068 CDD:278785 13/69 (19%)
FERM_C2_MyoVII 2064..2159 CDD:270020
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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