Protein Alignment Nf2 and Moe

DIOPT Version :10

• Sequence 1: XP_063128952.1
• Gene: Nf2 / 25744
• RGDID: 3169
• Length: 653
• Species: Rattus norvegicus
• Sequence 2: NP_727290.1
• Gene: Moe / 31816
• FlyBaseID: FBgn0011661
• Length: 649
• Species: Drosophila melanogaster
• Alignment Length: 705
• Identity: 271/705 - (38%)
• Similarity: 385/705 - (54%)
• Gaps: 137/705 - (19%)

  Rat    13 SLKRKQPKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYT-IKDTVAWLK 76
            |:||   ||..||:.|||||:||..:....||.|||.|.:|:||||.|||||||| .|....|:|
  Fly    18 SVKR---KTLNVRVTTMDAELEFAIQSTTTGKQLFDQVVKTIGLREVWFFGLQYTDSKGDSTWIK 79

  Rat    77 MDKK-----------------------------------------------------VLDHDVSK 88
            :.||                                                     |::.||.|
  Fly    80 LYKKPESPAIKTIKYLKRVKKYVDKKTADSNGVNHLETSEEDDDADDMTGSMPFSTWVMNQDVKK 144

  Rat    89 EEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKVYCPPEASVLLASYAVQAKYGDY 153
            |.|:.|.|.||||||:..|||:|:||..||:||||..||.:::|||||.|||||||||||::||:
  Fly   145 ENPLQFRFRAKFYPEDVAEELIQDITLRLFYLQVKNAILTDEIYCPPETSVLLASYAVQARHGDH 209

  Rat   154 DPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYG 218
            :.:.|..||||.:.|||:|||:.::|:.:.||:.|..|:.|||...|::|.||||||||||||||
  Fly   210 NKTTHTAGFLANDRLLPQRVIDQHKMSKDEWEQSIMTWWQEHRSMLREDAMMEYLKIAQDLEMYG 274

  Rat   219 VNYFTIRHSGGRSRRISVSSNVSLKPAWSTELSSRTTRTTQKKLSKTKTEFLANLFYLEEEEKYN 283
            ||||.||                                                         |
  Fly   275 VNYFEIR---------------------------------------------------------N 282

  Rat   284 KKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKIDVFKFNSSKLR 348
            ||||:|.||||||||:||:.::||||||.|||:||||||:|:|:|.|||:|||...|.|.:.::|
  Fly   283 KKGTDLWLGVDALGLNIYEQDDRLTPKIGFPWSEIRNISFSEKKFIIKPIDKKAPDFMFFAPRVR 347

  Rat   349 VNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLAREKQMREEAERTRDEL 413
            :||.||.||:|||:|:|||||.|:::||||||||||||..||.||::|......||.||:.:.|.
  Fly   348 INKRILALCMGNHELYMRRRKPDTIDVQQMKAQAREEKNAKQQEREKLQLALAARERAEKKQQEY 412

  Rat   414 ERRLLQMKEEATMANEALMRSEETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAIRTEE 478
            |.||.||:|:...:...|:.:::....|       ||:.|.|.....|.|...:.::|...|.||
  Fly   413 EDRLKQMQEDMERSQRDLLEAQDMIRRL-------EEQLKQLQAAKDELELRQKELQAMLQRLEE 470

  Rat   479 EKRL--MEQKVLEAEVLALKM-----AEESERRAKEADQLKQDLQEAREAE---RRAKQKLLEIA 533
            .|.:  :|:..||.|::|.:|     .:|...:.:|..:|:.::::||..:   ..|...||..:
  Fly   471 AKNMEAVEKLKLEEEIMAKQMEVQRIQDEVNAKDEETKRLQDEVEDARRKQVIAAEAAAALLAAS 535

  Rat   534 TKPTYPPMNPIPAPLPPDIPSFDIIGDSLSFDFKDTDMKRLSMEIEKEKVEYMEKSKHLQEQLNE 598
            |.|.:..:.........::.:.|..|| :|.|. ||| :.:...||..:. ..|:::.|.:||..
  Fly   536 TTPQHHHVAEDENENEEELTNGDAGGD-VSRDL-DTD-EHIKDPIEDRRT-LAERNERLHDQLKA 596

  Rat   599 LKTEIEALKLKERETALDILHSEHSDRGGTSSKHNTIKKLTLQSAKSRVAFFEEL 653
            ||.::...:.:.:|||.|.:|.|:..:|  ..|:.|::::...:.|.||..||.:
  Fly   597 LKQDLAQSRDETKETANDKIHRENVRQG--RDKYKTLREIRKGNTKRRVDQFENM 649

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nf2	XP_063128952.1	None
Moe	NP_727290.1	B41	26..278	CDD:214604	116/251 (46%)
		FERM_C_ERM	272..368	CDD:270015	65/152 (43%)
		ERM_helical	402..521	CDD:466641	35/125 (28%)
		ERM_C	573..649	CDD:459932	22/78 (28%)