Protein Alignment SNX33 and VPS5

DIOPT Version :10

• Sequence 1: NP_695003.1
• Gene: SNX33 / 257364
• HGNCID: 28468
• Length: 574
• Species: Homo sapiens
• Sequence 2: NP_014712.2
• Gene: VPS5 / 854235
• SGDID: S000005595
• Length: 675
• Species: Saccharomyces cerevisiae
• Alignment Length: 684
• Identity: 143/684 - (20%)
• Similarity: 240/684 - (35%)
• Gaps: 200/684 - (29%)

Human    17 EEISIQQD--EDLVIFSETSLDGWLQGQNSRGETGLF--PASYVEIVRSGISTNHADYSSSPAGS 77
            :|::.:.|  :.||..|..|: |.:.....|.:..|.  .||:.:.:....:....|...|.||:
Yeast    13 DELNHEGDKTQSLVSNSIESI-GQISTNEERKDNELLETTASFADKIDLDSAPEWKDPGLSVAGN 76

Human    78 PGAQ---------------------VSLYNSPSVASPARSGGGSGFLSNQGSFEEDDDDDWDDWD 121
            |..:                     ..|.||.:.....|..||:.|..|..|....||..:|
Yeast    77 PQLEEHDNSKADDLINSLAPEQDPIADLKNSTTQFIATRESGGALFTGNANSPLVFDDTIYD--- 138

Human   122 DGCTVVEEPRAGGLGTNGHPPLNLSYPGAYPSQ-HMAF---RPKPPLERQDSLASAKRGSVVG-- 180
                           .|..|..:.|..|....: .:.|   |.:...:|..|| .|||.:...
Yeast   139 ---------------ANTSPNTSKSISGRRSGKPRILFDSARAQRNSKRNHSL-KAKRTTASDDT 187

Human   181 ----------------------------RNLNRFSCFVRSGVEAFILGDV--PMM------AKIA 209
                                        |..|....|..| ||..||..|  |:.      |.|:
Yeast   188 IKTPFTDPLKKAEKENEFVEEPLDDRNERRENNEGKFTAS-VEKNILEQVDRPLYNLPQTGANIS 251

Human   210 ETYSIE----------MGPRGPQWKANPHPFACSVEDPTKQTKFKGIKSYISYKLTPTHAA---- 260
            ....:|          :|.:.|..: ....|...|:||.|..:...|  ::.|.:....:.
Yeast   252 SPAEVEENSEKFGKTKIGSKVPPTE-KAVAFKVEVKDPVKVGELTSI--HVEYTVISESSLLELK 313

Human   261 -SPVYRRYKHFDWLYNRLLHKFTVISVPHLPEKQATGRFEEDFIEKRKRRLILWMDHMTSHPVLS 324
             :.|.|||:.|.|||.:|.:......:|..||||:.|.|:|:|||.|:.::...:..:...|||.
Yeast   314 YAQVSRRYRDFRWLYRQLQNNHWGKVIPPPPEKQSVGSFKENFIENRRFQMESMLKKICQDPVLQ 378

Human   325 QYEGFQHFLSCLDDKQWKMGKRRAEKDEMVGASFLLTFQIPTEHQDLQDVEDRVDTFKAFSKKMD 389
            :.:.|..||:. ||...:..||          :||.......:..||.:|  |:
Yeast   379 KDKDFLLFLTS-DDFSSESKKR----------AFLTGSGAINDSNDLSEV--RI----------- 419

Human   390 DSVLQL--STVASELVRKHVGGFRKEFQKLGSAFQAISHS----------FQMDPPFCSEALNSA 442
             |.:||  :..|:|:::.  ||...|..|   .|.:||.|          |.::.....:.|...
Yeast   420 -SEIQLLGAEDAAEVLKN--GGIDAESHK---GFMSISFSSLPKYNEADEFFIEKKQKIDELEDN 478

Human   443 ISHTGRTYEAIGEMFAEQPKNDL-------FQMLDTLSLY------QGLLSNFPDIIHLQKGAF- 493
            :....::.|.:     :..:|.|       ..|::||:..      ..||:||.|:....|.:.
Yeast   479 LKKLSKSLEMV-----DTSRNTLAASTEEFSSMVETLASLNVSEPNSELLNNFADVHKSIKSSLE 538

Human   494 -AKVKESQRMSDEGRMVQDEADGI-------RRRCRVVGF--ALQAEMNHFH------------- 535
             :.::|:..|   |.|:.|....:       .:|.::..|  .::.:||..|
Yeast   539 RSSLQETLTM---GVMLDDYIRSLASVKAIFNQRSKLGYFLVVIENDMNKKHSQLGKLGQNIHSE 600

Human   536 ----QRRELDFKHMMQNYLRQQILFYQRVGQQLE 565
                .|:|........|..::|   :|.||.:::
Yeast   601 KFREMRKEFQTLERRYNLTKKQ---WQAVGDKIK 631

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SNX33	NP_695003.1	SH3_SNX33	4..58	CDD:212829	11/44 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	68..119		16/71 (23%)
		PX_domain	230..354	CDD:470617	38/128 (30%)
		BAR_SNX33	365..571	CDD:153353	48/254 (19%)
VPS5	NP_014712.2	PX_Vps5p	281..390	CDD:132771	34/111 (31%)
		BAR_Vps5p	460..673	CDD:153311	31/183 (17%)