Protein Alignment SNX33 and SH3PX1

DIOPT Version :10

• Sequence 1: NP_695003.1
• Gene: SNX33 / 257364
• HGNCID: 28468
• Length: 574
• Species: Homo sapiens
• Sequence 2: NP_648348.1
• Gene: SH3PX1 / 39136
• FlyBaseID: FBgn0040475
• Length: 565
• Species: Drosophila melanogaster
• Alignment Length: 585
• Identity: 194/585 - (33%)
• Similarity: 318/585 - (54%)
• Gaps: 43/585 - (7%)

Human     6 RALYDFHSE-NKEEISIQQDEDLVIFSETSLDGWLQGQNSRGETGLFPASYVEIVRSGISTNHAD 69
            ||:|||..| ...|:||...:.|.:......:||.:|:|:||:.|||||:|||:    :|...|.
  Fly     6 RAMYDFTGEPGSSELSIATGDVLSVTRSDVGEGWWEGKNARGQIGLFPAAYVEV----MSAAEAQ 66

Human    70 YSSSPAGSPGAQV-SLYNSPSVASPARSGGGSGFLSNQGSFEEDDDDDWDDWDDGCTVV------ 127
            ..|:...:...|| ..:.||.:....::....|  ||.     ||:|||.|.:|..:.:
  Fly    67 KLSASGATSVPQVPDPFASPPLPRYDQTADDDG--SNW-----DDEDDWSDDNDTYSEIGPGGQK 124

Human   128 ---EEPRAGGLGTNGHPPLNLSYPGAYPSQHMAFRPKPPLERQDSLASAKRGSVVGRNLNRFSCF 189
               :..|||||..:         ...|.::|:   |..|.:...||||...|:.....:.: ..|
  Fly   125 SAGQSARAGGLSHS---------TSDYDNKHL---PIAPNDDTQSLASVAGGTGAAGTVKK-GMF 176

Human   190 VRSGVEAFILGDVPMMAKIAE---TYSIEMGPRGPQWKANPHPFACSVEDPTKQTKFKGIKSYIS 251
            .:|. :::|||......||.|   .|..::.....||..|..|::..|..|.|::||||:|::|:
  Fly   177 AKSS-DSYILGLSSTKEKIPECEMAYITQVEDSIYQWTQNHSPYSVVVASPKKESKFKGMKTFIA 240

Human   252 YKLTPTHAASPVYRRYKHFDWLYNRLLHKFTVISVPHLPEKQATGRFEEDFIEKRKRRLILWMDH 316
            |:|||:.....|.|||||||||:.||:.||.:|.||.||:||.:||:||.|:|.|:.:|..::|.
  Fly   241 YQLTPSFNNISVSRRYKHFDWLHERLVDKFCLIPVPPLPDKQISGRYEEQFVEHRRVQLQEFVDW 305

Human   317 MTSHPVLSQYEGFQHFLSCLDDKQWKMGKRRAEKDEMVGASFLLTFQIPTEHQDLQDVEDRVDTF 381
            :..|||:|:.|.:.|||:|.|:|.||.|||:||:|..:|.::.|....|.::.....|:.:|:..
  Fly   306 VCRHPVISKCEVWYHFLTCRDEKIWKSGKRKAERDPYMGVNYCLAISPPDKNLLHSKVDAQVELG 370

Human   382 KAFSKKMDDSVLQLSTVASELVRKHVGGFRKEFQKLGSAFQAISHSFQMD----PPFCSEALNSA 442
            ..|...||.:|..|:.:::::.::.:...:||||::|.....::.:..:|    |...:..|:.:
  Fly   371 TQFIHSMDVAVRNLNNISNDMAKRSMSQSKKEFQRIGDGLSDLAKALAIDERRAPTRNAVPLSES 435

Human   443 ISHTGRTYEAIGEMFAEQPKNDLFQMLDTLSLYQGLLSNFPDIIHLQKGAFAKVKESQRMSDEGR 507
            :...|..:..||:.|.:|||:|...:.|.|.:|:|:|:.||||....|||..|.|:.::::.|||
  Fly   436 VGRIGGIFIGIGQAFGDQPKHDWIPLSDRLHIYRGVLNCFPDIFSTHKGAIQKRKDCEKLAGEGR 500

Human   508 MVQDEADGIRRRCRVVGFALQAEMNHFHQRRELDFKHMMQNYLRQQILFYQRVGQQLEKTLRMYD 572
            |...:...:.||..||.:.:.||:.||...|:...||.::|::.:||.|||.|..:|::..|..:
  Fly   501 MNNPQLHDVNRRTDVVSYTVLAELTHFKSERDTHLKHTLKNFIAEQIKFYQGVVARLQEASRQIE 565

Human   573  572
              Fly   566  565

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SNX33	NP_695003.1	SH3_SNX33	4..58	CDD:212829	23/52 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	68..119		14/51 (27%)
		PX_domain	230..354	CDD:470617	62/123 (50%)
		BAR_SNX33	365..571	CDD:153353	62/209 (30%)
SH3PX1	NP_648348.1	SH3_SNX9_like	4..59	CDD:212697	23/52 (44%)
		PX_SNX9_18_like	219..343	CDD:132772	62/123 (50%)
		BAR_SNX9_like	362..564	CDD:153310	61/201 (30%)