Protein Alignment SNX33 and lst-4

DIOPT Version :10

• Sequence 1: NP_695003.1
• Gene: SNX33 / 257364
• HGNCID: 28468
• Length: 574
• Species: Homo sapiens
• Sequence 2: NP_001379029.1
• Gene: lst-4 / 178361
• WormBaseID: WBGene00003086
• Length: 592
• Species: Caenorhabditis elegans
• Alignment Length: 511
• Identity: 182/511 - (35%)
• Similarity: 278/511 - (54%)
• Gaps: 46/511 - (9%)

Human    71 SSSPAGSP--GAQVSLYNSPSVASPARSGGGSGFLSNQGSFEEDDDDDWDDWDDGCTVVEEPR-- 131
            :|..|..|  |||.....:|||....|        |:..|..:|.||:|.|.||    .:||.
 Worm   119 ASEVAAPPSYGAQHHHQPTPSVPEVTR--------SSYPSQNDDFDDEWTDEDD----EQEPTRP 171

Human   132 --AGGLGTNGHPPLNLSYPGAYPSQHMAFRPKPPLERQDSLASAKRGS-VVGRNLNRFSCFVRSG 193
              ...:|:|....|:.|:     |:|               ....||| .|.:|:||||.||:||
 Worm   172 NVQSSIGSNSRRDLSRSH-----SEH---------------GGPDRGSNKVNKNINRFSNFVKSG 216

Human   194 VEAFILGDVPMMAKIAETYSIEMGPRGPQWKANPHPFACSVEDPTKQTKFKGIKSYISYKLTP-- 256
            |||:::|:....::|:|.:.:.|.....|||.....:.|.|:.|.|::|.||:||:|:|.:|.
 Worm   217 VEAYVIGESKTTSQISERHEVVMNNGIIQWKPIQQYYTCIVDKPKKESKLKGLKSFIAYSITSSL 281

Human   257 THAASPVYRRYKHFDWLYNRLLHKFTVISVPHLPEKQATGRFEEDFIEKRKRRLILWMDHMTSHP 321
            |:....|.|||||||||:.:|..|:.:|.:|.|||||..||:|||.|:.||..|.||::.:..||
 Worm   282 TNIQRQVSRRYKHFDWLHEQLSAKYVLIPIPPLPEKQVAGRYEEDLIDHRKHILQLWVNKICRHP 346

Human   322 VLSQYEGFQHFLSCLDDKQWKMGKRRAEKDEMVGASFLLTFQIPTEHQDLQDVEDRVDTFKAFSK 386
            ||||.|.:.||:||.|:|.||.|||||||||.:|.:||....:|.:..|..:|:.:|:.|:...|
 Worm   347 VLSQSEVWLHFISCTDEKDWKNGKRRAEKDEYIGGAFLNCITVPHQPLDPNNVDMQVERFQRSVK 411

Human   387 KMDDSVLQLSTVASELVRKHVGGFRKEFQKLGSAFQAISHSFQMDPPFCSEALNSAISHTGRTYE 451
            ..::::..:....:...:...|..::.:||:||||:.:..||::|....|..|..|:::|...|.
 Worm   412 TSEEAMRVMQERMNMFQKVFAGPVKQNWQKMGSAFKTLQQSFEIDETVASRRLTEALAYTASEYH 476

Human   452 AIGEMFAEQPKNDLFQMLDTLSLYQGLLSNFPDIIHLQKGAFAKVKESQRMSDEGRMVQDEADGI 516
            .||::|....|||:..:|:.|..|:|.:.|.||||.:.|.|..|.::|     |||:...||:.:
 Worm   477 EIGQVFDAHTKNDMEPVLENLYSYKGTVQNVPDIIQVHKQAVQKFRDS-----EGRLSSAEAEKM 536

Human   517 RRRCRVVGFALQAEMNHFHQRRELDFKHMMQNYLRQQILFYQRVGQQLEKTLRMYD 572
            ::|...:.:.:.||:.|....:..|.|..|..||::|.:|||.|..:|......||
 Worm   537 KQRIDAMSYTVIAEVQHQTAEKVEDMKSTMGTYLKKQAMFYQEVATKLTSLAARYD 592

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SNX33	NP_695003.1	SH3_SNX33	4..58	CDD:212829
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	68..119		16/49 (33%)
		PX_domain	230..354	CDD:470617	67/125 (54%)
		BAR_SNX33	365..571	CDD:153353	60/205 (29%)
lst-4	NP_001379029.1	PX_SNX9_18_like	253..379	CDD:132772	67/125 (54%)
		BAR	362..592	CDD:472257	76/234 (32%)