DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kcnb1 and Shab

DIOPT Version :9

Sequence 1:	NP_037318.2	Gene:	Kcnb1 / 25736	RGDID:	2954	Length:	857	Species:	Rattus norvegicus
Sequence 2:	NP_001189037.1	Gene:	Shab / 38352	FlyBaseID:	FBgn0262593	Length:	1607	Species:	Drosophila melanogaster

Alignment Length:	996	Identity:	432/996 - (43%)
Similarity:	566/996 - (56%)	Gaps:	193/996 - (19%)

- Green bases have known domain annotations that are detailed below.

  Rat    10 SRSTSSL-PPEPMEIVRSKACSRRVRLNVGGLAHEVLWRTLDRLPRTRLGKLRDCNTHDSLLQVC 73
            |||.||: ||||..|.:|||.:.||.:||||:.||||||||:|||.||||:||:|.||::::::|
  Fly   285 SRSMSSIPPPEPFMIAQSKAVNSRVSINVGGVRHEVLWRTLERLPHTRLGRLRECTTHEAIVELC 349

  Rat    74 DDYSLEDNEYFFDRHPGAFTSILNFYRTGRLHMMEEMCALSFSQELDYWGIDEIYLESCCQARYH 138
            |||||.||||||||||.:|:|||||||||:||:::|||.|:||.:|:|||:||:|||||||.:||
  Fly   350 DDYSLADNEYFFDRHPKSFSSILNFYRTGKLHIVDEMCVLAFSDDLEYWGVDELYLESCCQHKYH 414

  Rat   139 QKKEQMNEELKREAETLREREGEEFDNTCCAEKRKKLWDLLEKPNSSVAAKILAIISIMFIVLST 203
            |:||.::||:::|||:||:|:.|||....|||.:|.||:||||||:|.||:::|:|||:||||||
  Fly   415 QRKENVHEEMRKEAESLRQRDEEEFGEGKCAEYQKYLWELLEKPNTSFAARVIAVISILFIVLST 479

  Rat   204 IALSLNTLPELQSLDEFGQSTDNPQLAHVEAVCIAWFTMEYLLRFLSSPKKWKFFKGPLNAIDLL 268
            |||:|||||:||.:|. |...||||||.||||||.|||:||:|||.:||.|||||||.||.||||
  Fly   480 IALTLNTLPQLQHIDN-GTPQDNPQLAMVEAVCITWFTLEYILRFSASPDKWKFFKGGLNIIDLL 543

  Rat   269 AILPYYVTIFLTESNKSVL-QFQNVRRVVQIFRIMRILRILKLARHSTGLQSLGFTLRRSYNELG 332
            |||||:|::||.|:||:.. |||:||||||:|||||||||||||||||||||||||||.||.|||
  Fly   544 AILPYFVSLFLLETNKNATDQFQDVRRVVQVFRIMRILRILKLARHSTGLQSLGFTLRNSYKELG 608

  Rat   333 LLILFLAMGIMIFSSLVFFAEKDEDDTKFKSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLC 397
            ||:||||||::|||||.:||||||.||||.|||.:||||.|||||||||||||.|.|||::|.:|
  Fly   609 LLMLFLAMGVLIFSSLAYFAEKDEKDTKFVSIPETFWWAGITMTTVGYGDIYPTTALGKVIGTVC 673

  Rat   398 CIAGVLVIALPIPIIVNNFSEFYKEQKRQEKAIKRREALERAKRNGSIVS---MNMKDAFARSIE 459
            ||.||||||||||||||||:||||.|.|:|||:||||||:||||.|||||   :|:|||||:|::
  Fly   674 CICGVLVIALPIPIIVNNFAEFYKNQMRREKALKRREALDRAKREGSIVSFHHINLKDAFAKSMD 738

  Rat   460 MMDIVVE--KNGESIAKKDKVQDNHLSPNKWKWTKRALS----------------ETSSSKSFET 506
            ::|::|:  |....:..|.|.|.   :||..:.|....|                |::|.::..|
  Fly   739 LIDVIVDTGKQTNVVHPKGKRQS---TPNIGRQTLDVQSAPGHNLSQTDGNSTEGESTSGRNPAT 800

  Rat   507 KEQG--------------SPEKARSSSSPQ---------HLNVQQLEDMYSKMAKTQSQPILNTK 548
            ...|              :....|.|||.|         :.|.:|...|..:..:.:.|.:|..:
  Fly   801 TGTGCYKNYDHVANLRNSNLHNRRGSSSEQDAVPPYSFDNPNARQTSMMAMESYRREQQALLQQQ 865

  Rat   549 EMAPQSKPPEELEMSSMPSPVAPLPARTEGVIDMRSMSSIDSFISCATDFPEATRFSHSPLASLS 613
            :.  |.:...:::.....:|.....|...||.:..:|.:..   |.||....||..|::
  Fly   866 QQ--QQQQMLQMQQIQQKAPNGNGGATGGGVANNLAMVAAS---SAATAVATATNASNA------ 919

  Rat   614 SKAGSSTAPEVGWRGALG---ASGGRLTETN-------PIPETSRSGFFVESPR----------- 657
                |:|||  |..||.|   ..||.:.:.|       ||......|...|..|
  Fly   920 ----SNTAP--GSEGAEGGGDGDGGGVDDDNLSQAKGLPIQMMITPGEVAELRRQVALENLQNQR 978

  Rat   658 -SSMKTNNPLKLRALKV------NFVEGDPTPLLPSLGLYHDP--LRNRGGAAAAVAG------- 706
             .:::.:.|::......      .|.:.:....||:.. :|.|  |..|..||...||
  Fly   979 MDNLEQDVPVEFECCFCTTKDFKEFTDAEGVISLPTSD-FHKPICLEMRLAAAGRQAGAYGLLSP 1042

  Rat   707 -----------------------LECASLLDKPVLSPESSIYTTASARTPPRSPEKHTAIAF--- 745
                                   ..||::| .|.:|..||..::....|       .|.||.
  Fly  1043 LPAPLPPLHGPLLALPPPPPLPPTSCAAVL-LPAISQSSSTSSSYGTTT-------STTIALPLD 1099

  Rat   746 -------------NFEAGVHHYIDTDT---DDEGQLLY---------------SVDSSPPKSLHG 779
                         ||....::..:|.|   ...|.||:               |||||   ..:.
  Fly  1100 VSLRYGATICSSSNFNHNYNNNFNTTTVGGGGNGTLLFGGNYNGSNNNNADLASVDSS---DTYA 1161

  Rat   780 S--TSPKFSTGARTEKNHFESSPLPTSPK--FLRP------NCVYSSEGL--------TGKGPGA 826
            |  |.|..|.|..|...:.|:..|.....  ::.|      ..:.||.|.        :..||.|
  Fly  1162 SCQTHPFLSQGDLTADFNDEACALDIDMDNLYINPLEREQHQGISSSTGFIVGLPSTNSSGGPRA 1226

  Rat   827 QEKCKLENHTPPDVHMLPGGG 847
            |.|......|.  :..|..||
  Fly  1227 QVKKSASGDTA--LRNLAAGG 1245

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kcnb1	NP_037318.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21		8/11 (73%)
		BTB_POZ_KCNB2	15..141	CDD:349719	85/126 (67%)
		Self-association. /evidence=ECO:0000269\|PubMed:18463252, ECO:0000269\|PubMed:19690160	59..75		6/15 (40%)
		Ion_trans	188..424	CDD:395416	181/236 (77%)
		Selectivity filter. /evidence=ECO:0000250\|UniProtKB:P63142	377..382		4/4 (100%)
		Self-association. /evidence=ECO:0000269\|PubMed:18463252, ECO:0000269\|PubMed:19690160	448..481		13/34 (38%)
		Kv2channel	467..678	CDD:397541	52/277 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	476..524		15/86 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	540..569		3/28 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	610..658		16/69 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	770..802		10/33 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	818..857		10/38 (26%)
Shab	NP_001189037.1	BTB	309..416	CDD:197585	74/106 (70%)
		BTB_2	309..408	CDD:280393	68/98 (69%)
		Ion_trans	501..700	CDD:278921	157/198 (79%)
		Ion_trans_2	613..696	CDD:285168	65/82 (79%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	362	1.000	Domainoid score	I919
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002877
OrthoInspector	1	1.000	-	-		otm46099
orthoMCL	1	0.900	-	-		OOG6_101602
Panther	1	1.100	-	-	LDO	PTHR11537
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.810