DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hnf4a and Hnf4

DIOPT Version :9

Sequence 1:	XP_006235577.1	Gene:	Hnf4a / 25735	RGDID:	2810	Length:	484	Species:	Rattus norvegicus
Sequence 2:	NP_723413.1	Gene:	Hnf4 / 44544	FlyBaseID:	FBgn0004914	Length:	732	Species:	Drosophila melanogaster

Alignment Length:	469	Identity:	254/469 - (54%)
Similarity:	315/469 - (67%)	Gaps:	66/469 - (14%)

- Green bases have known domain annotations that are detailed below.

  Rat    41 SPSEGANLNSS-----NSLGVS--------------------ALCAICGDRATGKHYGASSCDGC 80
            |.|.|:|.|:|     |:|..|                    .:|||||||||||||||||||||
  Fly   126 SASSGSNNNNSMFSPNNNLSGSGSGTNSSQQQLQQQQQQQSPTVCAICGDRATGKHYGASSCDGC 190

  Rat    81 KGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYE 145
            ||||||||||||.|:|||:|.||||||||||||||||:|||:||||||||||||||||.||:|.:
  Fly   191 KGFFRRSVRKNHQYTCRFARNCVVDKDKRNQCRYCRLRKCFKAGMKKEAVQNERDRISCRRTSND 255

  Rat   146 DSSLP----SINALLQAEVLSQQITSPIS---GINGDIRAKRIANITDVCESMKEQLLVLVEWAK 203
            |.. |    |:.:|::||..|:|..:..:   .||.|:..|:.|:|.|||||||:|||.||||||
  Fly   256 DPD-PGNGLSVISLVKAENESRQSKAGAAMEPNINEDLSNKQFASINDVCESMKQQLLTLVEWAK 319

  Rat   204 YIPAFCELLLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPE-----LAEMSR 263
            .||||.||.|||||||||||||||||||.::|||..||||||.|:.::.||||:     ..::||
  Fly   320 QIPAFNELQLDDQVALLRAHAGEHLLLGLSRRSMHLKDVLLLSNNCVITRHCPDPLVSPNLDISR 384

  Rat   264 VSIRILDELVLPFQELQIDDNEYACLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQY 328
            :..||:||||...:::.|||.|:||:||::||||:||||::|.:||.||.|:..:|||||:||||
  Fly   385 IGARIIDELVTVMKDVGIDDTEFACIKALVFFDPNAKGLNEPHRIKSLRHQILNNLEDYISDRQY 449

  Rat   329 DSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSASDAPHAHHPLHPHL 393
            :|||||||:||:||.||||||||||||||.|:||:|.||:|||||||||..:|.|....|  |:.
  Fly   450 ESRGRFGEILLILPVLQSITWQMIEQIQFAKIFGVAHIDSLLQEMLLGGELADNPLPLSP--PNQ 512

  Rat   394 MQEHMGTNVIVANTMPSHLSNGQMCEWPRPRGQAGGQPGVNSTRATPETPQPSPPSGSGSESYKL 458
            ..::..         |:|..|           ..||.. |||:..:..|     ..|.||.|..|
  Fly   513 SNDYQS---------PTHTGN-----------MEGGNQ-VNSSLDSLAT-----SGGPGSHSLDL 551

  Rat   459 LPGAITTIVKPPSA 472
            ....|..:::..||
  Fly   552 EVQHIQALIEANSA 565

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hnf4a	XP_006235577.1	NR_DBD_HNF4A	60..135	CDD:143518	68/74 (92%)
Hnf4a	XP_006235577.1	NR_LBD_HNF4_like	151..373	CDD:132729	140/229 (61%)
Hnf4	NP_723413.1	NR_DBD_HNF4A	170..245	CDD:143518	68/74 (92%)
Hnf4	NP_723413.1	NR_LBD_HNF4_like	264..494	CDD:132729	140/229 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	254	1.000	Domainoid score	I1985
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	453	1.000	Inparanoid score	I1552
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003424
OrthoInspector	1	1.000	-	-		otm46456
orthoMCL	1	0.900	-	-		OOG6_105157
Panther	1	1.100	-	-	LDO	PTHR24083
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1958
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.960