DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Prkar1a and Pka-R2

DIOPT Version :9

Sequence 1:	NP_037313.1	Gene:	Prkar1a / 25725	RGDID:	3391	Length:	381	Species:	Rattus norvegicus
Sequence 2:	NP_523671.1	Gene:	Pka-R2 / 36041	FlyBaseID:	FBgn0022382	Length:	377	Species:	Drosophila melanogaster

Alignment Length:	383	Identity:	145/383 - (37%)
Similarity:	221/383 - (57%)	Gaps:	30/383 - (7%)

- Green bases have known domain annotations that are detailed below.

  Rat     1 MASGSMAASEEERSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKEEARQI 65
            |:|.|....:....|:|           .||:.|| .....:|...:.:..|||.:|:.|.....
  Fly     1 MSSDSSRRIQVPEELKE-----------VLLQFSI-SFLVEQPPDVIDYAVEYFTKLQSERPSVS 53

  Rat    66 QSLQKSG--IRTDSREDEISPPPPNPVVKGRRRRGAISAEVY-----TEEDAASYVRKVIPKDYK 123
            .:.|.:.  :..:|::.:..||     |....||.::.||.|     .::|.|:   .|.||..:
  Fly    54 HTDQSTDDQLSVNSQDADAEPP-----VMASSRRKSVFAEAYDPEADDDDDGAT---AVFPKTDE 110

  Rat   124 TMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQGDEGDNFYVIDQGEMDVYVNN 188
            ..|.|.::::..:||..|:..:.:.:.||||......|:.:|:|||:|||||||:.|...||:|:
  Fly   111 QRARLVESVKNVLLFRSLEKEQMNQVLDAMFERKVQPGDFIIRQGDDGDNFYVIESGVYKVYIND 175

  Rat   189 EWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKV 253
            :...:....|.||||||:|..||||||:|:|:..||.:||.::||||:.|..||||||||.|:.|
  Fly   176 KHINTYNHTGLFGELALLYNMPRAATVQAETSGLLWAMDRQTFRRILLKSAFRKRKMYEELLNSV 240

  Rat   254 SILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGTAAVLQRRSENEEFVEVGRL 318
            .:|::|..:||:.:||||....:::|::|:.||:..|..:.|.|||.:|  |..:::..||:.:|
  Fly   241 PMLKALQNYERMNLADALVSKSYDNGERIIKQGDAADGMYFIEEGTVSV--RMDQDDAEVEISQL 303

  Rat   319 GPSDYFGEIALLMNRPRAATVVAR-GPLKCVKLDRPRFERVLGPCSDILKRNIQQYNS 375
            |...||||:||:.:|||||:|.|. |.:|...||...|||:||||.||:||||..|.|
  Fly   304 GKGQYFGELALVTHRPRAASVYATGGVVKLAFLDVKAFERLLGPCMDIMKRNIDDYES 361

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prkar1a	NP_037313.1	Dimerization and phosphorylation	2..136		31/140 (22%)
		DD_RIalpha_PKA	14..63	CDD:213048	12/48 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	65..96		5/32 (16%)
		Pseudophosphorylation motif	96..100		2/3 (67%)
		CAP_ED	137..246	CDD:237999	52/108 (48%)
		CAP_ED	255..370	CDD:237999	51/115 (44%)
Pka-R2	NP_523671.1	DD_RII_PKA	11..49	CDD:213046	11/49 (22%)
		CAP_ED	124..233	CDD:237999	52/108 (48%)
		CAP_ED	242..356	CDD:237999	51/115 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0664
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54324
OrthoDB	1	1.010	-	-		D1047290at2759
OrthoFinder	1	1.000	-	-		FOG0000531
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100449
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X421
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.730