DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NEGR1 and DIP-epsilon

DIOPT Version :9

Sequence 1:	NP_776169.2	Gene:	NEGR1 / 257194	HGNCID:	17302	Length:	354	Species:	Homo sapiens
Sequence 2:	NP_001137799.1	Gene:	DIP-epsilon / 7354433	FlyBaseID:	FBgn0259714	Length:	467	Species:	Drosophila melanogaster

Alignment Length:	319	Identity:	94/319 - (29%)
Similarity:	146/319 - (45%)	Gaps:	67/319 - (21%)

- Green bases have known domain annotations that are detailed below.

Human    45 VDNMMVRKGDTAVLRCYLED-GASKGAWLN--RSSIIFAGGDKWSVDPRVSISTLNKRD----YS 102
            ::|:.|..|....|.|.::: |:.|.||::  :|:|:.......:.:||:|: |.:|.|    :.
  Fly    58 IENITVPAGRNVKLACSVKNLGSYKVAWMHFEQSAILTVHNHVITRNPRISV-THDKHDKHRTWF 121

Human   103 LQIQNVDVTDDGPYTCSVQTQHTPRTMQVHLTVQVPPKIYD--ISNDMTVNEGTNVTLTCLATGK 165
            |.|.||...|.|.|.|.:.|. |.:|....:.|.|||.|.|  .|:|:.|.||.||||.|.|.|.
  Fly   122 LHINNVQEEDRGRYMCQINTV-TAKTQYGFVKVVVPPNIDDALTSSDIIVREGDNVTLRCKAKGS 185

Human   166 PEPSISWRH-------ISPSAKPFE-NGQYLDIYGITRDQAGEYECSAENDVSFPDV-RKVKVVV 221
            |||:|.|:.       |:.:.:..: ....|::..|:|...|.|.|.|.|.|. |.| :::||.|
  Fly   186 PEPTIKWKRDDGNKIVINKTLEVHDLETDSLELERISRLHMGAYLCIASNGVP-PSVSKRIKVSV 249

Human   222 NFAPTIQEIKSGTVTPGRSGLIRCEGAGVP--------------PPAFEWYKGEKKLFNGQQGII 272
            :|:|.:              .|..:..|:|              |.:..::..|    |.|....
  Fly   250 DFSPMV--------------WIPHQLVGIPIGFNITLECFIEANPTSLNYWTRE----NDQMITE 296

Human   273 IQNFSTRSI-----------LTVTNVTQEHFGNYTCVAANKLGTTNASLPL---NPPST 317
            ...:.|.:|           ||:|||....:|||.|||.|..|..:.::.|   :||:|
  Fly   297 SSKYKTETIPGHPSYKATMRLTITNVQSSDYGNYKCVAKNPRGDMDGNIKLYMSSPPTT 355

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NEGR1	NP_776169.2	IG	47..135	CDD:214652	28/94 (30%)
		IGc2	152..210	CDD:197706	23/65 (35%)
		Ig_3	225..301	CDD:372822	21/100 (21%)
DIP-epsilon	NP_001137799.1	IG_like	59..155	CDD:214653	29/97 (30%)
		Ig	69..139	CDD:143165	22/70 (31%)
		IG_like	165..249	CDD:214653	31/84 (37%)
		IGc2	172..237	CDD:197706	23/64 (36%)
		IG_like	267..348	CDD:214653	19/84 (23%)
		Ig	270..339	CDD:299845	18/72 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143439
Domainoid	1	1.000	45	1.000	Domainoid score	I12195
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D265311at33208
OrthoFinder	1	1.000	-	-		FOG0000150
OrthoInspector	1	1.000	-	-		mtm8497
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X97
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.750