DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NEGR1 and DIP-delta

DIOPT Version :9

Sequence 1:	NP_776169.2	Gene:	NEGR1 / 257194	HGNCID:	17302	Length:	354	Species:	Homo sapiens
Sequence 2:	NP_001097508.2	Gene:	DIP-delta / 5740816	FlyBaseID:	FBgn0085420	Length:	469	Species:	Drosophila melanogaster

Alignment Length:	310	Identity:	91/310 - (29%)
Similarity:	127/310 - (40%)	Gaps:	43/310 - (13%)

- Green bases have known domain annotations that are detailed below.

Human    45 VDNMMVRKGDTAVLRCYLED-GASKGAW--LNRSSIIFAGGDKWSVDPRVSISTLNKRDYSLQIQ 106
            :.|:.|..|..|.|.|.:|. |..|.||  ::|..|:.......|..||.|| |.....:.|.:.
  Fly    50 IPNVTVAVGRDANLPCVVEHLGGYKVAWIHIDRQMILTIHRHVISRIPRYSI-TYTDNTWLLHVN 113

Human   107 NVDVTDDGPYTCSVQTQHTPRTMQV-HLTVQVPPKIYDIS---NDMTVNEGTNVTLTCLATGKPE 167
            .....|.|.|.|.|.|  .|...|| :|.|.|||.|.||.   :.:.|.|..|:.:||.|.|.|.
  Fly   114 QAHQDDRGYYMCQVNT--NPMISQVGYLQVVVPPNILDIESTPSSVAVRENQNINMTCRADGFPA 176

Human   168 PSISWRHISPSAKPFENGQYLDIYG--------ITRDQAGEYECSAENDVSFPDV-RKVKVVVNF 223
            |.|.||.........|..:.:.:|.        ::|::.|.|.|.|.|.|. |.| :::.:.|.|
  Fly   177 PKIIWRREDGEEIAVEKKKKVLVYDADVLPLTKVSRNEMGAYLCIATNGVP-PSVSKRIILDVEF 240

Human   224 APTIQEIKSGTVTP-GRSGLIRCEGAGVPPPAFEWYKGEKKLFNGQQGIIIQNFST--------- 278
            :|.|.........| |....|.|.....|.....|      ::|....:..:.:.|
  Fly   241 SPMIWVPNQLVGAPSGTDVTIDCHTEAHPKAIIYW------VYNSVMVLPSKKYKTDYTENSYRA 299

Human   279 RSILTVTNVTQEHFGNYTCVAANKLGTTNAS-----LPLNPPSTAQYGIT 323
            ...||:.|:....||||.|::.|.||.|..|     :||  |||....:|
  Fly   300 HMKLTIRNLQYGDFGNYRCISKNSLGETEGSIRVYEIPL--PSTPSKQVT 347

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NEGR1	NP_776169.2	IG	47..135	CDD:214652	30/91 (33%)
		IGc2	152..210	CDD:197706	19/65 (29%)
		Ig_3	225..301	CDD:372822	18/85 (21%)
DIP-delta	NP_001097508.2	IG	51..143	CDD:214652	31/94 (33%)
		Ig	145..238	CDD:416386	27/93 (29%)
		Ig strand A	145..149	CDD:409353	2/3 (67%)
		Ig strand A'	154..159	CDD:409353	0/4 (0%)
		Ig strand B	165..172	CDD:409353	2/6 (33%)
		Ig strand C	178..183	CDD:409353	2/4 (50%)
		Ig strand C'	185..187	CDD:409353	0/1 (0%)
		Ig strand D	195..199	CDD:409353	0/3 (0%)
		Ig strand E	203..209	CDD:409353	0/5 (0%)
		Ig strand F	216..223	CDD:409353	3/6 (50%)
		Ig strand G	230..238	CDD:409353	1/7 (14%)
		Ig	242..333	CDD:416386	23/96 (24%)
		Ig strand A'	250..253	CDD:409353	0/2 (0%)
		Ig strand B	259..266	CDD:409353	2/6 (33%)
		Ig strand C	272..277	CDD:409353	1/10 (10%)
		Ig strand C'	281..283	CDD:409353	0/1 (0%)
		Ig strand D	289..293	CDD:409353	1/3 (33%)
		Ig strand E	295..305	CDD:409353	1/9 (11%)
		Ig strand F	314..322	CDD:409353	4/7 (57%)
		Ig strand G	325..334	CDD:409353	3/8 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	45	1.000	Domainoid score	I12195
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D265311at33208
OrthoFinder	1	1.000	-	-		FOG0000150
OrthoInspector	1	1.000	-	-		mtm8497
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X97
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.820