DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NEGR1 and CG34353

DIOPT Version :9

Sequence 1:	NP_776169.2	Gene:	NEGR1 / 257194	HGNCID:	17302	Length:	354	Species:	Homo sapiens
Sequence 2:	NP_001287571.1	Gene:	CG34353 / 5740590	FlyBaseID:	FBgn0085382	Length:	581	Species:	Drosophila melanogaster

Alignment Length:	318	Identity:	92/318 - (28%)
Similarity:	146/318 - (45%)	Gaps:	43/318 - (13%)

- Green bases have known domain annotations that are detailed below.

Human    37 SVDFPWAAVDNMMVRK---------------GDTAVLRCYLED-GASKGAWLNRSSIIFAGGDKW 85
            |:.|...:..:||.:.               |:|.||.|.:.: .....||....:|:.||..|.
  Fly    69 SLHFESVSAQSMMTKNEPMFISRSETFKFITGETIVLPCEVANTDTYVVAWKRGIAILTAGSVKV 133

Human    86 SVDPRVSISTLNKRDYSLQIQNVDVTDDGPYTCSVQTQHTPRTMQVHLTVQVPPKIYDIS--NDM 148
            :.||||.:    ...::|||::...||.|.|.|.:.|. .||.:...:.:.|||:|:.||  ..:
  Fly   134 TPDPRVRL----VNGFNLQIRDALPTDAGDYICQIATM-DPREITHTVEILVPPRIHHISTGGHL 193

Human   149 TVNEGTNVTLTCLATGKPEPSISW---RHISPSAKPFENGQYLDIYGITRDQAGEYECSAENDVS 210
            .|.:|::|.:.|.|||.|.|:::|   .:|.|:.:...:...|.|..:.|.:.|.|.|:|.|.|.
  Fly   194 QVKKGSSVRIECSATGNPMPNVTWSRKNNILPNGEEKLHSHVLSIENVDRHKGGVYICTANNRVG 258

Human   211 FPDVRKVKVVVNFAPTIQ----EIKSGTVTPGRSGLIRCEGAGVPPPAFEWYKGEKKLFNGQQGI 271
            .|...:|.:.|.|:|.|.    .:.||   .|....:.|...|...|...|:|...:|...::.
  Fly   259 QPASSQVVLHVLFSPEISVERPVVFSG---EGHEATLVCIVHGETQPEVIWFKDTMQLDTTERH- 319

Human   272 IIQNFSTRSILTVTNVTQEHFGNYTCVAANKLGTTNASLPL---------NPPSTAQY 320
            |::...:|..|.:..|..:.||||:|||.|:||....:|.|         |.|..:||
  Fly   320 IMETRGSRHTLIIRKVHPQDFGNYSCVAENQLGKARKTLQLSGKPNVAVFNSPPISQY 377

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NEGR1	NP_776169.2	IG	47..135	CDD:214652	28/103 (27%)
		IGc2	152..210	CDD:197706	19/60 (32%)
		Ig_3	225..301	CDD:372822	22/79 (28%)
CG34353	NP_001287571.1	IG_like	100..180	CDD:214653	26/84 (31%)
		Ig	103..177	CDD:143165	24/78 (31%)
		IG_like	191..269	CDD:214653	23/77 (30%)
		IGc2	198..258	CDD:197706	19/59 (32%)
		I-set	273..360	CDD:254352	26/90 (29%)
		Ig	290..359	CDD:143165	20/69 (29%)
		FN3	<466..524	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X97
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810