Protein Alignment NEGR1 and DIP-gamma

DIOPT Version :10

• Sequence 1: NP_776169.2
• Gene: NEGR1 / 257194
• HGNCID: 17302
• Length: 354
• Species: Homo sapiens
• Sequence 2: NP_651649.1
• Gene: DIP-gamma / 43417
• FlyBaseID: FBgn0039617
• Length: 413
• Species: Drosophila melanogaster
• Alignment Length: 323
• Identity: 90/323 - (27%)
• Similarity: 141/323 - (43%)
• Gaps: 51/323 - (15%)

Human    45 VDNMMVRKGDTAVLRCYLED-GASKGAWLNRS--SIIFAGGDKWSVDPRVSISTLNKRDYSLQIQ 106
            ::|:....|..|:|.|.:.: |.:|..||..|  :::...|...:.:.|:|:...:...:.|:|.
  Fly    45 INNVTYPAGREAILACSVRNLGKNKVGWLRASDQTVLALQGRVVTHNARISVMHQDMHTWKLKIS 109

Human   107 NVDVTDDGPYTCSVQTQHTPRTMQVH-LTVQVPPKIY--DISNDMTVNEGTNVTLTCLATGKPEP 168
            .:..:|.|.|.|.:.|  :|...||. :.|||||.|.  :.|.|:.|.||.:.||||.|||.|:|
  Fly   110 KLRESDRGCYMCQINT--SPMKKQVGCIDVQVPPDIINEESSADLAVQEGEDATLTCKATGNPQP 172

Human   169 SISWRH--------ISPSAKPF-----ENGQYLDIYGITRDQAGEYECSAENDVSFPDVRKVKVV 220
            .::||.        ..|.::..     .||..|.:..:.|.|.|.|.|.|.|||.....::|.:.
  Fly   173 RVTWRREDGEMILIRKPGSRELMKVESYNGSSLRLLRLERRQMGAYLCIASNDVPPAVSKRVSLS 237

Human   221 VNFAPTIQEIKSGTVTP-GRSGLIRCEGAGVPPPAFEWYKGEK---------------------K 263
            |.|||.::.......|| |....:.|:....|.|...|.||.:                     .
  Fly   238 VQFAPMVRAPSQLLGTPLGSDVQLECQVEASPSPVSYWLKGARTSNGFASVSTASLESGSPGPEM 302

Human   264 LFNG-QQGIIIQNFSTRSI--LTVTNVTQEHFGNYTCVAANKLGTTNASL-----PLNPPSTA 318
            |.:| :.||..:....|.:  |.|.:.:....|.|.||:.|.||....:|     .|:|.::|
  Fly   303 LLDGPKYGITERRDGYRGVMLLVVRSFSPSDVGTYHCVSTNSLGRAEGTLRLYEIKLHPGASA 365

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NEGR1	NP_776169.2	IG_like	47..135	CDD:214653	23/91 (25%)
		Ig strand B	56..60	CDD:409353	2/3 (67%)
		Ig strand C	68..72	CDD:409353	1/3 (33%)
		Ig strand E	101..105	CDD:409353	1/3 (33%)
		Ig strand F	115..120	CDD:409353	2/4 (50%)
		Ig strand G	128..131	CDD:409353	0/2 (0%)
		Ig_3	138..207	CDD:464046	29/83 (35%)
		IG_like	231..312	CDD:214653	24/110 (22%)
		Ig strand B	241..245	CDD:409353	0/3 (0%)
		Ig strand C	254..258	CDD:409353	0/3 (0%)
		Ig strand E	280..284	CDD:409353	1/5 (20%)
		Ig strand F	294..299	CDD:409353	2/4 (50%)
DIP-gamma	NP_651649.1	Ig	47..129	CDD:472250	21/83 (25%)
		Ig strand B	56..60	CDD:409353	2/3 (67%)
		Ig strand C	69..73	CDD:409353	1/3 (33%)
		Ig strand E	104..108	CDD:409353	1/3 (33%)
		Ig strand F	118..123	CDD:409353	2/4 (50%)
		Ig	141..238	CDD:472250	32/96 (33%)
		Ig strand B	160..164	CDD:409562	2/3 (67%)
		Ig strand C	173..177	CDD:409562	0/3 (0%)
		Ig strand E	203..207	CDD:409562	1/3 (33%)
		Ig strand F	217..222	CDD:409562	2/4 (50%)
		Ig strand G	231..234	CDD:409562	0/2 (0%)
		IG_like	247..355	CDD:214653	24/107 (22%)
		Ig strand B	259..263	CDD:409358	0/3 (0%)
		Ig strand C	272..276	CDD:409358	0/3 (0%)
		Ig strand E	317..326	CDD:409358	2/8 (25%)
		Ig strand F	336..341	CDD:409358	2/4 (50%)