Protein Alignment NEGR1 and Ama

DIOPT Version :10

• Sequence 1: NP_776169.2
• Gene: NEGR1 / 257194
• HGNCID: 17302
• Length: 354
• Species: Homo sapiens
• Sequence 2: NP_731114.2
• Gene: Ama / 40831
• FlyBaseID: FBgn0000071
• Length: 341
• Species: Drosophila melanogaster
• Alignment Length: 285
• Identity: 87/285 - (30%)
• Similarity: 134/285 - (47%)
• Gaps: 26/285 - (9%)

Human    53 GDTAVLRCYLED-GASKGAWLNR------SSIIFAGGDKWSV-DPRVSIST-----LNKRDYSLQ 104
            ||:....|.:|: |....:|..|      :|::.:..:..|: |.|.:::.     .....|:.:
  Fly    47 GDSVEFNCTVEEVGQLSVSWAKRPSESDTNSVVLSMRNILSLPDQRYNVTVTEGPKTGSAIYTFR 111

Human   105 IQNVDVTDDGPYTCSVQTQHTPR-TMQVHLTVQVPPKIYDISNDMT-VNEGTNVTLTCLATGKPE 167
            |||::|:|.|||.|.|....|.: |.::.|.::.||.|.:.:...| |.||.|:.|||.|.|.|:
  Fly   112 IQNIEVSDMGPYECQVLVSATEKVTKKLSLQIKTPPVIAENTPKSTLVTEGQNLELTCHANGFPK 176

Human   168 PSISWRH----ISPSAKPFENGQYLDIYGITRDQAGEYECSAENDVSFPDVRKVKVVVNFAP--T 226
            |:|||..    :.|:.........|.|..:.|...|.|.|.|:|....||.|.::|.|.|.|  .
  Fly   177 PTISWAREHNAVMPAGGHLLAEPTLRIRSVHRMDRGGYYCIAQNGEGQPDKRLIRVEVEFRPQIA 241

Human   227 IQEIKSGTVTPGRSGLIRCEGAGVPPPAFEWYKGEKKLFNGQQGIIIQNFS----TRSILTVTNV 287
            :|..|...:. ..|..:.|...|.|.|...|:|....|.:.:...:....|    |.|:|.:.:|
  Fly   242 VQRPKIAQMV-SHSAELECSVQGYPAPTVVWHKNGVPLQSSRHHEVANTASSSGTTTSVLRIDSV 305

Human   288 TQEHFGNYTCVAANKLGTTNASLPL 312
            .:|.||:|.|.|.||||..:|.|.|
  Fly   306 GEEDFGDYYCNATNKLGHADARLHL 330

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NEGR1	NP_776169.2	IG_like	47..135	CDD:214653	25/95 (26%)
		Ig strand B	56..60	CDD:409353	0/3 (0%)
		Ig strand C	68..72	CDD:409353	0/3 (0%)
		Ig strand E	101..105	CDD:409353	1/3 (33%)
		Ig strand F	115..120	CDD:409353	3/4 (75%)
		Ig strand G	128..131	CDD:409353	1/2 (50%)
		Ig_3	138..207	CDD:464046	26/73 (36%)
		IG_like	231..312	CDD:214653	26/84 (31%)
		Ig strand B	241..245	CDD:409353	0/3 (0%)
		Ig strand C	254..258	CDD:409353	0/3 (0%)
		Ig strand E	280..284	CDD:409353	2/3 (67%)
		Ig strand F	294..299	CDD:409353	2/4 (50%)
Ama	NP_731114.2	I-set	33..143	CDD:400151	25/95 (26%)
		Ig strand B	50..54	CDD:409353	0/3 (0%)
		Ig strand C	63..68	CDD:409353	1/4 (25%)
		Ig strand E	101..112	CDD:409353	1/10 (10%)
		Ig strand F	122..127	CDD:409353	3/4 (75%)
		Ig strand G	136..139	CDD:409353	1/2 (50%)
		Ig_3	146..220	CDD:464046	26/73 (36%)
		I-set	254..330	CDD:400151	25/75 (33%)
		Ig strand B	255..259	CDD:409353	0/3 (0%)
		Ig strand C	268..272	CDD:409353	0/3 (0%)
		Ig strand E	298..302	CDD:409353	2/3 (67%)
		Ig strand F	312..317	CDD:409353	2/4 (50%)