DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NEGR1 and Dscam2

DIOPT Version :9

Sequence 1:	NP_776169.2	Gene:	NEGR1 / 257194	HGNCID:	17302	Length:	354	Species:	Homo sapiens
Sequence 2:	NP_001261500.1	Gene:	Dscam2 / 38788	FlyBaseID:	FBgn0265296	Length:	2101	Species:	Drosophila melanogaster

Alignment Length:	274	Identity:	74/274 - (27%)
Similarity:	113/274 - (41%)	Gaps:	33/274 - (12%)

- Green bases have known domain annotations that are detailed below.

Human    48 MMVRKGDTAVLRCYLEDGASKGAWLNRSSIIFAGGDKWSVDPRVSISTLNKRDYSLQIQNVDVTD 112
            :.|..|.||..||.:   .|.|:.:...:|:      |..|.| .:.:..:.:.:|.:..|...:
  Fly   340 LSVHMGGTAEFRCLV---TSNGSPVGMQNIL------WYKDGR-QLPSSGRVEDTLVVPRVSREN 394

Human   113 DGPYTCSVQTQHTPRTMQVHLTVQV---PPKIYDISNDMTVNEGTNVTLTCLATGKPEPSISWR- 173
            .|.|.|.|:..... |.|....:|:   ||.:.....:.|:..|..|:|.|.|.|.|.|.|||.
  Fly   395 RGMYQCVVRRPEGD-TFQATAELQLGDAPPVLLYSFIEQTLQPGPAVSLKCSAAGNPTPQISWTL 458

Human   174 --HISPSAKPFENGQYLDIYG----------ITRDQAGEYECSAENDVSFPDVRKVKVVVNFAPT 226
              ...||...|..|||:.::|          :..:..|||.|.|||...... ...::.:...|.
  Fly   459 DGFPLPSNGRFMIGQYITVHGDVISHVNISHVMVEDGGEYACIAENRAGRVQ-HAARLNIYGLPY 522

Human   227 IQEIKSGTVTPGRSGLIRCEGAGVPPPAFEWYKGEKKLFNGQQGIIIQNFSTRSILTVTNVTQ-E 290
            |:.|...|...|.:..::|..||.|.....|.:|.::|.:.    |.|.......||::.|.: .
  Fly   523 IRLIPKVTAVSGETLNLKCPVAGYPIEEIHWERGGRELPDD----IRQRVQPDGSLTISPVQKNS 583

Human   291 HFGNYTCVAANKLG 304
            ..|.|||.|.||.|
  Fly   584 DSGVYTCWARNKQG 597

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NEGR1	NP_776169.2	IG	47..135	CDD:214652	20/86 (23%)
		IGc2	152..210	CDD:197706	25/70 (36%)
		Ig_3	225..301	CDD:372822	22/76 (29%)
Dscam2	NP_001261500.1	Ig	51..127	CDD:299845
		Ig	138..>203	CDD:299845
		I-set	238..327	CDD:254352
		Ig	247..327	CDD:299845
		I-set	332..418	CDD:254352	20/88 (23%)
		IGc2	344..407	CDD:197706	17/72 (24%)
		IG_like	432..517	CDD:214653	26/85 (31%)
		IGc2	436..507	CDD:197706	25/70 (36%)
		I-set	521..610	CDD:254352	25/81 (31%)
		IGc2	533..597	CDD:197706	20/67 (30%)
		Ig	630..699	CDD:143165
		IG_like	714..802	CDD:214653
		Ig	725..802	CDD:299845
		Ig	823..894	CDD:143165
		FN3	906..1006	CDD:238020
		FN3	1013..1111	CDD:238020
		FN3	1119..1209	CDD:238020
		FN3	1219..1313	CDD:238020
		Ig	1336..1402	CDD:143165
		FN3	1409..1498	CDD:238020
		FN3	1515..1588	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900