DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NEGR1 and dpr20

DIOPT Version :9

Sequence 1:	NP_776169.2	Gene:	NEGR1 / 257194	HGNCID:	17302	Length:	354	Species:	Homo sapiens
Sequence 2:	NP_612066.1	Gene:	dpr20 / 38101	FlyBaseID:	FBgn0035170	Length:	525	Species:	Drosophila melanogaster

Alignment Length:	211	Identity:	47/211 - (22%)
Similarity:	79/211 - (37%)	Gaps:	58/211 - (27%)

- Green bases have known domain annotations that are detailed below.

Human    47 NMMVRKGDTAVLRCYL----------------EDGASKGAWLNRSSIIFAGGDKWSVDPRVSIST 95
            |:.|:.|.:..|.|.:                ::|...|   |...::..|...::.|.|..:..
  Fly   278 NLTVQAGSSIHLNCRISLLQDKTVSWVRHNTQDEGKDNG---NALDLLTVGMHTYTGDKRYKMEF 339

Human    96 LNKRDYSLQIQNVDVTDDGPYTCSVQTQHTPRTMQVHLTVQVP-------------PKIYDISND 147
            ....::.|:|.||...|:..|.|.:.| |.||.:|::|.|..|             .|.|:|  |
  Fly   340 QYPNNWRLKITNVKKDDEAIYECQIST-HPPRVIQINLHVNAPKVMIVDEVGDPLQEKYYEI--D 401

Human   148 MTVNEGTNVTLTCLATGKPEPS--ISWRH-------------ISPSAKPFENG--QYLDIYGITR 195
            .|:.      |:|:.......|  :.|:|             :|...:..|:|  ..|.|..|::
  Fly   402 STLQ------LSCVVRNVAMTSSVVFWKHMDNILNYDVTRGGVSVKTELMEDGANSTLSIAKISK 460

Human   196 DQAGEYECSAENDVSF 211
            ..:|.|.||.....:|
  Fly   461 TDSGNYTCSISEFQNF 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NEGR1	NP_776169.2	IG	47..135	CDD:214652	24/103 (23%)
		IGc2	152..210	CDD:197706	15/74 (20%)
		Ig_3	225..301	CDD:372822
dpr20	NP_612066.1	IG_like	278..365	CDD:214653	18/89 (20%)
		Ig	279..378	CDD:299845	23/102 (23%)
		Ig	400..471	CDD:299845	18/78 (23%)
		IG_like	402..480	CDD:214653	17/81 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810