DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NEGR1 and wrapper

DIOPT Version :9

Sequence 1:	NP_776169.2	Gene:	NEGR1 / 257194	HGNCID:	17302	Length:	354	Species:	Homo sapiens
Sequence 2:	NP_477404.1	Gene:	wrapper / 37555	FlyBaseID:	FBgn0025878	Length:	500	Species:	Drosophila melanogaster

Alignment Length:	232	Identity:	63/232 - (27%)
Similarity:	99/232 - (42%)	Gaps:	25/232 - (10%)

- Green bases have known domain annotations that are detailed below.

Human   102 SLQIQNVDVTDDGPYTCSVQTQHTPRTMQVHLTVQVPPKIYDISNDMTVNE-GTNVTLTCLATGK 165
            |||:.||..:|.|.|.|.:.:.......|..:.||:.|::....:|:|... |....:.|.|.|.
  Fly    95 SLQVANVQSSDTGDYYCEMNSDSGHVVQQHAIEVQLAPQVLIEPSDLTEQRIGAIFEVVCEAQGV 159

Human   166 PEPSISWR----HISPSAKPFENGQYLDIYGITRDQAGEYECSAENDVSFPDVRKVKVVVNFAPT 226
            |:|.|:||    .|.|.:.. .|.|.|.:...:|:|||..||.|.|.|..|.|..|.:.|.|:|.
  Fly   160 PQPVITWRLNGNVIQPQSNT-GNRQSLILEIKSRNQAGLIECVASNGVGEPAVANVYLHVLFSPE 223

Human   227 IQEIKSGTVTP-GRSGLIRCEGAGVPPPAFEWY-------------KGEKKLFNGQQGIIIQNF- 276
            :...:....|. |....:.|.....|....:|:             ..|.:|   |....:.::
  Fly   224 VSIPQPVVYTKLGSRAHLECIVEAAPAATVKWFHHGLPVALGAHSTTHESEL---QTNRSVDHYV 285

Human   277 -STRSILTVTNVTQEHFGNYTCVAANKLGTTNASLPL 312
             :.|.:|.|.:|.....|.|.|.|:|::...:.|:.|
  Fly   286 NAVRHMLVVKSVRNADMGQYECRASNQISVKSGSVEL 322

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NEGR1	NP_776169.2	IG	47..135	CDD:214652	10/32 (31%)
		IGc2	152..210	CDD:197706	22/62 (35%)
		Ig_3	225..301	CDD:372822	17/91 (19%)
wrapper	NP_477404.1	Ig	41..124	CDD:299845	9/28 (32%)
		IG_like	41..118	CDD:214653	9/22 (41%)
		IG_like	145..218	CDD:214653	26/73 (36%)
		Ig	147..219	CDD:299845	26/72 (36%)
		I-set	224..323	CDD:254352	19/102 (19%)
		IGc2	236..314	CDD:197706	16/80 (20%)
		FN3	339..431	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810