Protein Alignment NEGR1 and dpr19

DIOPT Version :10

• Sequence 1: NP_776169.2
• Gene: NEGR1 / 257194
• HGNCID: 17302
• Length: 354
• Species: Homo sapiens
• Sequence 2: NP_609392.1
• Gene: dpr19 / 34408
• FlyBaseID: FBgn0032233
• Length: 385
• Species: Drosophila melanogaster
• Alignment Length: 343
• Identity: 74/343 - (21%)
• Similarity: 129/343 - (37%)
• Gaps: 67/343 - (19%)

Human    48 MMVRKGDTAVLRCYLE-DGASKGAWLNRS--SIIFAGGDKWSVDPRVSIS-TLNKRDYSLQIQNV 108
            ::.:||..|:|.|.:: :..:..:|:.|.  .::..|....|.|.|..:. |.:...:||:|:.|
  Fly    50 VIAQKGGLAILPCVVKVNSPATVSWIRRKDFQLLTVGLSTHSSDKRFLVEHTRHMGHWSLRIKAV 114

Human   109 DVTDDGPYTCSVQTQHTPRTMQVHLTVQVPPKIYDISN--DMTVNEGTNVTLTC---LATGKPEP 168
            ...|.|.|.|.:...   .|..:.:.:::...:.:||:  ::.::|.:.:.|.|   .||..| .
  Fly   115 REEDRGFYECQLSIY---PTQSIVIELKIVEAVAEISSAPELHIDETSTLRLECKLKRATENP-A 175

Human   169 SISWRHISPSAK-PFENGQYLDIYGITRDQAGE-YECSAENDVSFPDVRKVKVVVNFAPTIQEIK 231
            .:.|.|.|.... ..:.|..:...|.:..|:|: |..|..|.             :.|....|..
  Fly   176 FVFWYHDSKMINYDSQGGFVVTSIGQSNPQSGQFYRSSPANK-------------SRATMPMESS 227

Human   232 SGTVTP--GRSGLIRCEGAGVPPPAFEWYKGEKKLFNGQQGIIIQNFSTRSILTVTNVTQEHFGN 294
            :|.:..  |.|..|:...|.||       .....:....|...:.|.|. |:|||..|...|.||
  Fly   228 NGVLNSLLGSSDAIKAPAANVP-------SSTPYMTQQHQSAYLLNPSV-SVLTVKQVNFRHAGN 284

Human   295 YTCVAANKLGTTNASLPLNPPSTAQY------------------------GITGSADVLFSCWYL 335
            |||..:|....:.....|....||..                        |:.|::.|..:...|
  Fly   285 YTCAPSNARPASITVHVLRGEKTAAMQHANRSILDTETNGNGTFGLITLGGLNGTSGVTLAGGIL 349

Human   336 VLTLSSFTSIFYLKNAIL 353
            .     |:.:|.|..|::
  Fly   350 Y-----FSGLFLLMGAVV 362

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NEGR1	NP_776169.2	IG_like	47..135	CDD:214653	21/90 (23%)
		Ig strand B	56..60	CDD:409353	2/3 (67%)
		Ig strand C	68..72	CDD:409353	0/3 (0%)
		Ig strand E	101..105	CDD:409353	2/3 (67%)
		Ig strand F	115..120	CDD:409353	2/4 (50%)
		Ig strand G	128..131	CDD:409353	1/2 (50%)
		Ig_3	138..207	CDD:464046	17/75 (23%)
		IG_like	231..312	CDD:214653	22/82 (27%)
		Ig strand B	241..245	CDD:409353	1/3 (33%)
		Ig strand C	254..258	CDD:409353	0/3 (0%)
		Ig strand E	280..284	CDD:409353	2/3 (67%)
		Ig strand F	294..299	CDD:409353	4/4 (100%)
dpr19	NP_609392.1	IG_like	50..127	CDD:214653	20/76 (26%)
		Ig strand B	58..62	CDD:409353	2/3 (67%)
		Ig strand C	71..75	CDD:409353	0/3 (0%)
		Ig strand E	107..111	CDD:409353	2/3 (67%)
		Ig strand F	121..126	CDD:409353	2/4 (50%)
		Ig	<265..298	CDD:472250	14/33 (42%)
		Ig strand E	270..274	CDD:409551	2/3 (67%)
		Ig strand F	284..289	CDD:409551	4/4 (100%)