DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NEGR1 and DIP-zeta

DIOPT Version :9

Sequence 1:	NP_776169.2	Gene:	NEGR1 / 257194	HGNCID:	17302	Length:	354	Species:	Homo sapiens
Sequence 2:	NP_723441.2	Gene:	DIP-zeta / 34231	FlyBaseID:	FBgn0051708	Length:	532	Species:	Drosophila melanogaster

Alignment Length:	305	Identity:	95/305 - (31%)
Similarity:	144/305 - (47%)	Gaps:	29/305 - (9%)

- Green bases have known domain annotations that are detailed below.

Human    45 VDNMMVRKGDTAVLRCYLED-GASKGAWLN--RSSIIFAGGDKWSVDPRVSISTLNKRD----YS 102
            ::|:.|..|....|.|.::: |:.|.||::  :|:|:.......:.:||:|: |.:|.|    :.
  Fly   119 IENVTVPAGRNVKLGCSVKNLGSYKVAWMHFEQSAILTVHNHVITRNPRISV-THDKHDRHRTWY 182

Human   103 LQIQNVDVTDDGPYTCSVQTQHTPRTMQVHLTVQVPPKIYD--ISNDMTVNEGTNVTLTCLATGK 165
            |.|.||...|.|.|.|.:.|. |.:|...:|.|.|||.|.|  .|:|:.|.||.|::|.|.|:|.
  Fly   183 LHINNVHEEDRGRYMCQINTV-TAKTQFGYLNVVVPPNIDDSLSSSDVIVREGANISLRCRASGS 246

Human   166 PEPSISWR-----HISPSAKPFEN---GQYLDIYGITRDQAGEYECSAENDVSFPDVRKVKVVVN 222
            |.|.|.|:     .|:.:.....|   |..|:|..|:|...|.|.|.|.|.|.....:::||.|:
  Fly   247 PRPIIKWKRDDNSRIAINKNHIVNEWEGDTLEITRISRLDMGAYLCIASNGVPPTVSKRIKVSVD 311

Human   223 FAPTIQEIKSGTVTP-GRSGLIRCEGAGVPPPAFEWYKGEKKL------FNGQQGIIIQNFSTRS 280
            |.|.:.........| |.:..|.|.....|.....|.:||..:      :..:..:.:..:.|..
  Fly   312 FPPMLLIPHQLVGAPEGFNVTIECFTEAHPTSLNYWTRGEGPIIHDSHKYKVEATVGLPAYKTHM 376

Human   281 ILTVTNVTQEHFGNYTCVAANKLGTTNASLPL---NPPSTAQYGI 322
            .||:.||:....|.|.|||.|..|.|:..:.|   .||:||..||
  Fly   377 KLTIINVSSGDDGIYKCVAKNPRGETDGIIRLYVSYPPTTASSGI 421

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NEGR1	NP_776169.2	IG	47..135	CDD:214652	29/94 (31%)
		IGc2	152..210	CDD:197706	23/65 (35%)
		Ig_3	225..301	CDD:372822	19/82 (23%)
DIP-zeta	NP_723441.2	IG_like	120..216	CDD:214653	30/97 (31%)
		Ig	130..200	CDD:143165	22/70 (31%)
		I-set	226..310	CDD:254352	29/83 (35%)
		IGc2	233..298	CDD:197706	23/64 (36%)
		Ig	313..410	CDD:299845	23/96 (24%)
		IG_like	325..410	CDD:214653	22/84 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143438
Domainoid	1	1.000	45	1.000	Domainoid score	I12195
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D265311at33208
OrthoFinder	1	1.000	-	-		FOG0000150
OrthoInspector	1	1.000	-	-		mtm8497
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6406
SonicParanoid	1	1.000	-	-		X97
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.780