Protein Alignment NEGR1 and DIP-iota

DIOPT Version :10

• Sequence 1: NP_776169.2
• Gene: NEGR1 / 257194
• HGNCID: 17302
• Length: 354
• Species: Homo sapiens
• Sequence 2: NP_001097100.1
• Gene: DIP-iota / 33925
• FlyBaseID: FBgn0031837
• Length: 376
• Species: Drosophila melanogaster
• Alignment Length: 317
• Identity: 98/317 - (30%)
• Similarity: 144/317 - (45%)
• Gaps: 34/317 - (10%)

Human    16 WLAAVLLSLCCLLPSCLPAGQSVDFPWAA-VDNMMVRKGDTAVLRCYLEDGAS-KGAWL--NRSS 76
            ||  :||...|...:......:.|..::. ::|..|..|..|:|.|.:.|..| |.|||  :..:
  Fly     9 WL--LLLQSVCFSQASFSELNNSDPKFSGPINNSTVPVGRDALLTCVVHDLVSFKVAWLRVDTQT 71

Human    77 IIFAGGDKWSVDPRVSISTLNKRDYSLQIQNVDVTDDGPYTCSVQTQHTPRTMQV-HLTVQVPPK 140
            |:.......:.:.|:|||....|.:.|:|::|..:|.|.|.|.:.|.  |...|: :|.|.|||.
  Fly    72 ILSIQNHVITKNHRISISHTEHRIWQLKIRDVQESDRGWYMCQINTD--PMKSQMGYLDVVVPPD 134

Human   141 I--YDISNDMTVNEGTNVTLTCLATGKPEPSISWRHISPSAKPF------------ENGQYLDIY 191
            |  |..|.|:..:.|.||||||.|||.|.|:|:||.  ..|.|.            ..||.|.::
  Fly   135 IVDYQTSQDVVRSTGQNVTLTCSATGVPMPTITWRR--EEATPILISDDGDREVFSVEGQNLTLW 197

Human   192 GITRDQAGEYECSAENDVSFPDVRKVKVVVNFAPTI----QEIKSGTVTPGRSGLIRCEGAGVPP 252
            .:.|...|.|.|.|.|.|.....::|.:||||||||    ..|..|.   |:...:.|.....|.
  Fly   198 QVQRSHMGAYLCIASNGVPPTVSKRVMLVVNFAPTIWTRYDTIYVGL---GQKLTLECITESQPA 259

Human   253 PAFEWYKGEKKLFNGQQGIIIQNFSTRSILTVT--NVTQEHFGNYTCVAANKLGTTN 307
            ....|.:..:.|..|....:..:...|.::.:|  .:|:..||.|.|.|.|.:|.|:
  Fly   260 SVNFWLRDSQLLQGGSYESVSVDHVFRIVMRITLRPITKRDFGEYICRAKNAMGQTD 316

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NEGR1	NP_776169.2	IG_like	47..135	CDD:214653	29/91 (32%)
		Ig strand B	56..60	CDD:409353	2/3 (67%)
		Ig strand C	68..72	CDD:409353	2/3 (67%)
		Ig strand E	101..105	CDD:409353	1/3 (33%)
		Ig strand F	115..120	CDD:409353	2/4 (50%)
		Ig strand G	128..131	CDD:409353	0/2 (0%)
		Ig_3	138..207	CDD:464046	31/82 (38%)
		IG_like	231..312	CDD:214653	18/79 (23%)
		Ig strand B	241..245	CDD:409353	0/3 (0%)
		Ig strand C	254..258	CDD:409353	0/3 (0%)
		Ig strand E	280..284	CDD:409353	0/3 (0%)
		Ig strand F	294..299	CDD:409353	2/4 (50%)
DIP-iota	NP_001097100.1	IG_like	39..125	CDD:214653	28/87 (32%)
		Ig strand B	48..52	CDD:143290	2/3 (67%)
		Ig strand C	61..65	CDD:143290	2/3 (67%)
		Ig strand E	96..100	CDD:143290	1/3 (33%)
		Ig strand F	110..115	CDD:143290	2/4 (50%)
		Ig	133..227	CDD:472250	33/95 (35%)
		Ig strand B	152..156	CDD:409562	3/3 (100%)
		Ig strand C	165..169	CDD:409562	1/3 (33%)
		Ig strand E	192..196	CDD:409562	2/3 (67%)
		Ig strand F	206..211	CDD:409562	2/4 (50%)
		Ig strand G	220..223	CDD:409562	0/2 (0%)
		Ig_3	231..310	CDD:464046	19/81 (23%)