Protein Alignment NEGR1 and dpr4

DIOPT Version :9

• Sequence 1: NP_776169.2
• Gene: NEGR1 / 257194
• HGNCID: 17302
• Length: 354
• Species: Homo sapiens
• Sequence 2: NP_001014616.2
• Gene: dpr4 / 3346160
• FlyBaseID: FBgn0053512
• Length: 323
• Species: Drosophila melanogaster
• Alignment Length: 364
• Identity: 72/364 - (19%)
• Similarity: 126/364 - (34%)
• Gaps: 135/364 - (37%)

Human    22 LSLCCLLP-------SCLPAGQSV-----DFPWAA--VDNMMVRK-----GDTAVLRCYLED-GA 66
            |...||:|       .|...|..|     :.|::.  .||...|:     |..|:|.|.:.: |.
  Fly    10 LKAICLVPLWLLLFLDCGMVGGEVPPHYWETPYSQPYFDNSSRREVTATVGQAALLHCRVRNLGD 74

Human    67 SKGAWLNRSS--IIFAGGDKWSVDPRV-SISTLNKRDYSLQIQNVDVTDDGPYTCSVQTQHTPRT 128
            ...:|:.:..  |:..|...::.|.|. |:.:....:::|:|.:....|.|.|.|.|.|:  |:.
  Fly    75 RAVSWIRKRDLHILTVGILTYTNDQRFQSLHSEGSDEWTLRISSPQPRDSGTYECQVSTE--PKI 137

Human   129 MQ-VHLTVQVP-PKIYDISN-DMTVNEGTNVTLTCLATGKPEPSISWRHISPSAKPFENGQYLDI 190
            .| ..|.|.|. .||  :.| ::.:..|:::.|||||...|
  Fly   138 SQGFRLNVVVSRAKI--LGNAELFIKSGSDINLTCLAMQSP------------------------ 176

Human   191 YGITRDQAGEYECSAENDVSFPDVRKVKVVVNFAPTIQEIKSGTVTPGRSGLIRCEGAGVPPPAF 255
                                                                       |||...
  Fly   177 -----------------------------------------------------------VPPSFI 182

Human   256 EWYKGEKKLFNGQQG---IIIQNFSTRSILTVTNVTQEHFGNYTCVAANKLGTTNASLPLN---- 313
            .||||::.:...|:|   :|.:..:..|.|.:...|....|||||..::   :.:||:.::
  Fly   183 YWYKGKRVMNYSQRGGINVITERSTRTSKLLIAKATPADSGNYTCSPSS---SDSASVVVHVING 244

Human   314 -PPSTAQYGITG----------SADVLFSCWYLVLTLSS 341
             .|:..|:|.:.          |...:.:.| :.:|::|
  Fly   245 EHPAAMQHGNSSATCLRPLSSTSVPFVLATW-MSMTVAS 282

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NEGR1	NP_776169.2	IG	47..135	CDD:214652	24/97 (25%)
		IGc2	152..210	CDD:197706	7/57 (12%)
		Ig_3	225..301	CDD:372822	18/78 (23%)
dpr4	NP_001014616.2	V-set	53..146	CDD:284989	23/94 (24%)
		IG_like	53..145	CDD:214653	23/93 (25%)
		ig	153..227	CDD:278476	24/156 (15%)
		IG_like	161..>227	CDD:214653	23/148 (16%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810