Protein Alignment NEGR1 and DIP-beta

DIOPT Version :10

• Sequence 1: NP_776169.2
• Gene: NEGR1 / 257194
• HGNCID: 17302
• Length: 354
• Species: Homo sapiens
• Sequence 2: NP_001138225.1
• Gene: DIP-beta / 33125
• FlyBaseID: FBgn0259245
• Length: 555
• Species: Drosophila melanogaster
• Alignment Length: 358
• Identity: 93/358 - (25%)
• Similarity: 150/358 - (41%)
• Gaps: 68/358 - (18%)

Human     9 GACC--SNQWLAAVLLSLCCLLPSCLPAGQS----------VDFPWAAVDNMMVRKGDTAVLRCY 61
            |:.|  :.:|...:||    ||.:|:....|          .||. ..::|:.:.:|..|...|.
  Fly    61 GSGCGPAIRWQLLLLL----LLGNCIDLTVSNKISSVGAFEPDFV-IPLENVTIAQGRDATFTCV 120

Human    62 LE---------DGAS---KGAWL--NRSSIIFAGGDKWSVDPRVSISTLNKRDYSLQIQNVDVTD 112
            :.         ||:|   |.||:  :..:|:.......:.:.|:|:...:...::|.|:.|.:.|
  Fly   121 VNNLGGHRVSGDGSSAPAKVAWIKADAKAILAIHEHVITNNDRLSVQHNDYNTWTLNIRGVKMED 185

Human   113 DGPYTCSVQTQHTPRTMQ-VHLTVQVPPKIY--DISNDMTVNEGTNVTLTCLATGKPEPSISWR- 173
            .|.|.|.|.|.  |..|| ..|.|.:||.|.  :.|.||.|.||.:..|.|.|.|.|:|.|:||
  Fly   186 AGKYMCQVNTD--PMKMQTATLEVVIPPDIINEETSGDMMVPEGGSAKLVCRARGHPKPKITWRR 248

Human   174 ------------HISPSAKPFENGQYLDIYGITRDQAGEYECSAENDVSFPDVRKVKVVVNFAPT 226
                        |....|:..| |:.|.:..|||.:.|.|.|.|.|.|.....:::|:.|:|.|.
  Fly   249 EDGREIIARNGSHQKTKAQSVE-GEMLTLSKITRSEMGAYMCIASNGVPPTVSKRMKLQVHFHPL 312

Human   227 IQEIKSGTVTPGRSGLIRCEGAGVPPPAFEWYKGEKKLFNGQQGIIIQN------------FSTR 279
            :|........|..:.:.........|.|..:::.|    ||:  :||..            ::..
  Fly   313 VQVPNQLVGAPVLTDVTLICNVEASPKAINYWQRE----NGE--MIIAGDRYALTEKENNMYAIE 371

Human   280 SILTVTNVTQEHFGNYTCVAANKLGTTNASLPL 312
            .||.:..:....||.|.|::.|.:|.|..::.|
  Fly   372 MILHIKRLQSSDFGGYKCISKNSIGDTEGTIRL 404

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NEGR1	NP_776169.2	IG_like	47..135	CDD:214653	26/102 (25%)
		Ig strand B	56..60	CDD:409353	1/3 (33%)
		Ig strand C	68..72	CDD:409353	2/3 (67%)
		Ig strand E	101..105	CDD:409353	1/3 (33%)
		Ig strand F	115..120	CDD:409353	2/4 (50%)
		Ig strand G	128..131	CDD:409353	2/3 (67%)
		Ig_3	138..207	CDD:464046	30/83 (36%)
		IG_like	231..312	CDD:214653	17/92 (18%)
		Ig strand B	241..245	CDD:409353	0/3 (0%)
		Ig strand C	254..258	CDD:409353	1/3 (33%)
		Ig strand E	280..284	CDD:409353	2/3 (67%)
		Ig strand F	294..299	CDD:409353	2/4 (50%)
DIP-beta	NP_001138225.1	Ig	98..209	CDD:472250	29/113 (26%)
		Ig strand B	115..119	CDD:409353	1/3 (33%)
		Ig strand C	139..143	CDD:409353	2/3 (67%)
		Ig strand E	174..178	CDD:409353	1/3 (33%)
		Ig strand F	188..193	CDD:409353	2/4 (50%)
		Ig strand G	202..205	CDD:409353	0/2 (0%)
		Ig	211..307	CDD:472250	32/96 (33%)
		Ig strand B	230..234	CDD:409353	1/3 (33%)
		Ig strand C	243..247	CDD:409353	1/3 (33%)
		Ig strand E	272..276	CDD:409353	1/3 (33%)
		Ig strand F	286..291	CDD:409353	2/4 (50%)
		Ig strand G	300..303	CDD:409353	0/2 (0%)
		IG_like	327..405	CDD:214653	17/84 (20%)
		Ig strand B	328..332	CDD:409353	0/3 (0%)
		Ig strand C	341..346	CDD:409353	0/4 (0%)
		Ig strand E	365..376	CDD:409353	2/10 (20%)
		Ig strand F	386..391	CDD:409353	2/4 (50%)
		Ig strand G	399..402	CDD:409353	0/2 (0%)