DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NEGR1 and CG6867

DIOPT Version :9

Sequence 1:	NP_776169.2	Gene:	NEGR1 / 257194	HGNCID:	17302	Length:	354	Species:	Homo sapiens
Sequence 2:	NP_573262.2	Gene:	CG6867 / 32782	FlyBaseID:	FBgn0030887	Length:	949	Species:	Drosophila melanogaster

Alignment Length:	212	Identity:	62/212 - (29%)
Similarity:	89/212 - (41%)	Gaps:	35/212 - (16%)

- Green bases have known domain annotations that are detailed below.

Human   137 VPPKIYDI-----SNDMTVNEGTNVTLTCLATGKPEPSISWR-------HISPSAKPFENGQYLD 189
            :||.|.||     ...:.|.||.::.|:|.|||.|.|.:.||       :::.......:||:|.
  Fly   429 IPPSITDIQVPDFQRTVIVEEGRSLNLSCTATGTPTPQVEWRREDGRTINVNGVEMASISGQFLR 493

Human   190 IYGITRDQAGEYECSAENDVSFPDVRKVKVVVNFAPTIQ--------EIKSGTVTPGRSGLIRCE 246
            ...|||.|...|.|.|.|.::........|.|.|||.|.        |.:|       |..:.|.
  Fly   494 FTNITRHQMAAYTCFANNGIAPVANATYLVEVQFAPMISVYRQMIYAEYQS-------SATLECL 551

Human   247 GAGVPPPAFEW---YKGEKKLFNGQQGI--IIQNFSTRSILTVTNVTQEHFGNYTCVAANKLGTT 306
            ....|.....|   |.|:....:.:.||  ..:.|.|...||::|:.::.||.|.|||.|:|..|
  Fly   552 VEAFPEAIRYWERAYDGKILDPSDKYGIESYPEGFKTTMRLTISNLRKDDFGYYHCVARNELNAT 616

Human   307 NASL---PLNPPSTAQY 320
            ..:.   |.:|.|...|
  Fly   617 MVNFEIAPQDPNSETPY 633

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NEGR1	NP_776169.2	IG	47..135	CDD:214652
		IGc2	152..210	CDD:197706	22/64 (34%)
		Ig_3	225..301	CDD:372822	23/88 (26%)
CG6867	NP_573262.2	Collagen	306..364	CDD:189968
		IG_like	442..525	CDD:214653	24/82 (29%)
		IGc2	449..511	CDD:197706	21/61 (34%)
		IG_like	544..612	CDD:214653	20/74 (27%)
		Ig	546..612	CDD:143165	18/65 (28%)
		OLF	694..937	CDD:280371
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	57	1.000	Domainoid score	I10858
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D265311at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.920