DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NEGR1 and dpr8

DIOPT Version :9

Sequence 1:	NP_776169.2	Gene:	NEGR1 / 257194	HGNCID:	17302	Length:	354	Species:	Homo sapiens
Sequence 2:	NP_001285239.1	Gene:	dpr8 / 32387	FlyBaseID:	FBgn0052600	Length:	344	Species:	Drosophila melanogaster

Alignment Length:	248	Identity:	59/248 - (23%)
Similarity:	99/248 - (39%)	Gaps:	48/248 - (19%)

- Green bases have known domain annotations that are detailed below.

Human    13 SNQWLAAVLLSLCCLLPSC-----------------LPAGQSVDFPWAAVDNMMVRKGDTAVLRC 60
            |..|:  :.|.:.|||..|                 .|......|......|:....|.|..|.|
  Fly     2 STHWI--IFLGILCLLAGCTDGASKRFFTDFLQDLPTPGTGGPTFDTTIGTNITGLVGKTVKLTC 64

Human    61 YLED-GASKGAWLNRSSI--IFAGGDKWSVDPRV-SISTLNKRDYSLQIQNVDVTDDGPYTCSVQ 121
            .::: |....:|:....|  :..|...::.|.|. ::.:.:..|::|:|:.....|.|.|.|.:.
  Fly    65 RVKNLGNRTVSWVRHRDIHLLTVGRYTYTSDQRFEAMHSPHAEDWTLRIRYAQRKDSGIYECQIS 129

Human   122 TQHTPRTMQVHLTVQVPPKIYDI--SNDMTVNEGTNVTLTCLATGKPE--PSISWRH-------I 175
            |. .|....|:|.:..|  :.||  ..::.:|.|:.:.|||:....||  |::.|.|       .
  Fly   130 TT-PPIGHSVYLNIVEP--VTDIIGGPELHINRGSTINLTCIVKFAPEPPPTVIWSHNREIINFD 191

Human   176 SPS---AKPFENG-----QYLDIYGITRDQAGEYECSAENDVSFPDVRKVKVV 220
            ||.   :...|.|     :.|....||:| :|.|.|:..|  :.|...:|.:|
  Fly   192 SPRGGISLVTEKGVLTTSRLLVQKAITQD-SGLYTCTPSN--ANPTSVRVHIV 241

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NEGR1	NP_776169.2	IG	47..135	CDD:214652	22/91 (24%)
		IGc2	152..210	CDD:197706	21/74 (28%)
		Ig_3	225..301	CDD:372822
dpr8	NP_001285239.1	IG_like	51..131	CDD:214653	18/79 (23%)
		V-set	52..143	CDD:284989	21/91 (23%)
		IG_like	153..238	CDD:214653	23/87 (26%)
		ig	153..232	CDD:278476	22/81 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810