Protein Alignment NEGR1 and DIP-kappa

DIOPT Version :10

• Sequence 1: NP_776169.2
• Gene: NEGR1 / 257194
• HGNCID: 17302
• Length: 354
• Species: Homo sapiens
• Sequence 2: NP_723828.1
• Gene: DIP-kappa / 318958
• FlyBaseID: FBgn0051814
• Length: 672
• Species: Drosophila melanogaster
• Alignment Length: 327
• Identity: 91/327 - (27%)
• Similarity: 149/327 - (45%)
• Gaps: 58/327 - (17%)

Human    34 AGQSVDFPWAA--VDNMMVRKGDTAVLRCYLED-GASKGAW--LNRSSIIFAGGDKWSVDPRVSI 93
            |.:..|||..|  :.|:.|..|..|::.|.:|: ...|.||  ::..:|:....:..|.:.|:|:
  Fly    67 AQEDSDFPRFAEPIANVTVSVGRDALMACVVENLKGYKVAWVRVDTQTILSIHHNVISQNSRISL 131

Human    94 STLNKRDYSLQIQNVDVTDDGPYTCSVQTQHTPRTMQVHLTVQVPPKIYD--ISNDMTVNEGTNV 156
            :..:.|.:.|.|:.|:.||.|.|.|.|.|. ..|:.:.:|.|.|||.|.:  .||||.|.||.|:
  Fly   132 TYNDHRSWYLHIKEVEETDRGWYMCQVNTD-PMRSRKGYLQVVVPPIIVEGLTSNDMVVREGQNI 195

Human   157 TLTCLATGKPEPSISWR------------HISPSAKPFENGQYLDIYGITRDQAGEYECSAENDV 209
            :|.|.|.|.|||.:.||            |::     ..:|:.|.|..::|.....|.|.|.|.|
  Fly   196 SLVCKARGYPEPYVMWRREDGEEMLIGGEHVN-----VVDGELLHITKVSRLHMAAYLCVASNGV 255

Human   210 SFPDVRKVKVVVNFAPTI---QEIKSGTVTPGRSGLIRCEGAGVPPPAFEWYKGEKKLFNGQQGI 271
            .....::|.:.|.|.|.:   .:::...:  |:..::.|.....|.....|        ..::|.
  Fly   256 PPSISKRVHLRVQFPPMLSIPNQLEGAYL--GQDVILECHTEAYPASINYW--------TTERGD 310

Human   272 IIQNFSTR------SILTVTNVTQ-----------EHFGNYTCVAANKLGTTNASLPLN---PPS 316
            :|.:.::|      :..||:..|:           ..||.|.|||.|.||.|:.::.|:   .|:
  Fly   311 MIISDTSRAGDKYETTSTVSGYTKYMKLKIRAVGPNDFGTYRCVAKNSLGETDGNIKLDEMPTPT 375

Human   317 TA 318
            ||
  Fly   376 TA 377

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NEGR1	NP_776169.2	IG_like	47..135	CDD:214653	26/90 (29%)
		Ig strand B	56..60	CDD:409353	1/3 (33%)
		Ig strand C	68..72	CDD:409353	3/5 (60%)
		Ig strand E	101..105	CDD:409353	1/3 (33%)
		Ig strand F	115..120	CDD:409353	2/4 (50%)
		Ig strand G	128..131	CDD:409353	0/2 (0%)
		Ig_3	138..207	CDD:464046	28/82 (34%)
		IG_like	231..312	CDD:214653	20/97 (21%)
		Ig strand B	241..245	CDD:409353	0/3 (0%)
		Ig strand C	254..258	CDD:409353	0/3 (0%)
		Ig strand E	280..284	CDD:409353	0/3 (0%)
		Ig strand F	294..299	CDD:409353	2/4 (50%)
DIP-kappa	NP_723828.1	IG_like	82..174	CDD:214653	27/92 (29%)
		Ig strand B	91..95	CDD:409353	1/3 (33%)
		Ig strand C	104..108	CDD:409353	2/3 (67%)
		Ig strand E	139..143	CDD:409353	1/3 (33%)
		Ig strand F	153..158	CDD:409353	2/4 (50%)
		Ig strand G	165..168	CDD:409353	0/2 (0%)
		Ig	176..267	CDD:472250	30/95 (32%)
		Ig strand B	195..199	CDD:409301	1/3 (33%)
		Ig strand C	208..212	CDD:409301	0/3 (0%)
		Ig strand E	232..236	CDD:409301	1/3 (33%)
		Ig strand F	246..251	CDD:409301	2/4 (50%)
		Ig strand G	260..263	CDD:409301	0/2 (0%)
		IG_like	282..368	CDD:214653	20/95 (21%)
		Ig strand B	288..292	CDD:409353	0/3 (0%)
		Ig strand C	301..305	CDD:409353	1/11 (9%)
		Ig strand E	330..340	CDD:409353	1/9 (11%)
		Ig strand F	350..355	CDD:409353	2/4 (50%)
		Ig strand G	363..366	CDD:409353	0/2 (0%)