Protein Alignment NEGR1 and DIP-alpha

DIOPT Version :9

• Sequence 1: NP_776169.2
• Gene: NEGR1 / 257194
• HGNCID: 17302
• Length: 354
• Species: Homo sapiens
• Sequence 2: NP_001259218.1
• Gene: DIP-alpha / 31322
• FlyBaseID: FBgn0052791
• Length: 554
• Species: Drosophila melanogaster
• Alignment Length: 317
• Identity: 87/317 - (27%)
• Similarity: 142/317 - (44%)
• Gaps: 57/317 - (17%)

Human    44 AVDNMMVRKGDTAVLRCYLED-GASKGAWLN---------RSSIIFAGGDKWSVDPRVSISTLNK 98
            ::.|:.|..|..|...|::.. |..:..||.         ..::|       :.:|||::|.|::
  Fly    47 SISNVSVAVGRDATFTCHVRHLGGYRVGWLKADTKAIQAIHENVI-------THNPRVTVSHLDQ 104

Human    99 RDYSLQIQNVDVTDDGPYTCSVQTQHTPRTMQV-HLTVQVPPKIY--DISNDMTVNEGTNVTLTC 160
            ..::|.|:.|...|.|.|.|.:.|.  |...|: .|.|.:||...  |.|:|:.|.||::|.|||
  Fly   105 NTWNLHIKAVSEEDRGGYMCQLNTD--PMKSQIGFLDVVIPPDFISEDTSSDVIVPEGSSVRLTC 167

Human   161 LATGKPEPSISWRH----------------ISPSAKPFENGQYLDIYGITRDQAGEYECSAENDV 209
            .|.|.|||.::||.                ::||.:    |:.|.:..|:|::.|.|.|.|.|.|
  Fly   168 RARGYPEPIVTWRREDGNEIVLKDNVGTKTLAPSFR----GEVLKLSKISRNEMGSYLCIASNGV 228

Human   210 SFPDV-RKVKVVVNFAPTIQEIKSGTVTP-GRSGLIRCEGAGVPPPAFEWYK--GEKKLFNGQQG 270
            . |.| :::.:.::|.|.||........| |....|.|.....|.....|.|  ||..:.:|:..
  Fly   229 P-PSVSKRISLSIHFHPVIQVPNQLVGAPLGTDVQIECHVEASPKSINYWIKDTGEMIVTSGKYH 292

Human   271 IIIQN---FSTRSILTVTNVTQEHFGNYTCVAANKLGTTNASLPLNPPSTAQYGITG 324
            :...:   :.|:..:.|....::..|:|.|:|.|.||..::|:.|       |.|.|
  Fly   293 VQESSQSMYETKMSMIVRKFQKDDVGSYRCIAKNSLGEVDSSIRL-------YEIPG 342

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NEGR1	NP_776169.2	IG	47..135	CDD:214652	25/98 (26%)
		IGc2	152..210	CDD:197706	24/73 (33%)
		Ig_3	225..301	CDD:372822	19/81 (23%)
DIP-alpha	NP_001259218.1	IG_like	49..129	CDD:214653	21/86 (24%)
		Ig	51..131	CDD:299845	21/88 (24%)
		I-set	144..240	CDD:254352	32/100 (32%)
		IGc2	159..228	CDD:197706	24/72 (33%)
		Ig	244..337	CDD:299845	23/92 (25%)
		I-set	244..337	CDD:254352	23/92 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	45	1.000	Domainoid score	I12195
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D265311at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8497
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X97
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.820