DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NEGR1 and rst

DIOPT Version :9

Sequence 1:	NP_776169.2	Gene:	NEGR1 / 257194	HGNCID:	17302	Length:	354	Species:	Homo sapiens
Sequence 2:	NP_001284835.1	Gene:	rst / 31290	FlyBaseID:	FBgn0003285	Length:	764	Species:	Drosophila melanogaster

Alignment Length:	328	Identity:	76/328 - (23%)
Similarity:	117/328 - (35%)	Gaps:	65/328 - (19%)

- Green bases have known domain annotations that are detailed below.

Human    45 VDNMMVRKGDTAVLRCYLEDGAS--KGAW-LNRSSIIFAGGDKWSVDPRVSISTLNKRDYSLQIQ 106
            |::..||      |.|..:...|  :..| :|...||  ||.|                ..:.|:
  Fly   272 VEHSQVR------LECRADANPSDVRYRWFINDEPII--GGQK----------------TEMVIR 312

Human   107 NVD-VTDDGPYTCSVQTQHTPRTMQVHLTVQVPPKIYDISNDMTVNEGTNVTLTCLATGKPEPSI 170
            ||. ...|....|.||...........|.:...|........|..:.|:.|:|||.....|:|.|
  Fly   313 NVTRKFHDAIVKCEVQNSVGKSEDSETLDISYAPSFRQRPQSMEADVGSVVSLTCEVDSNPQPEI 377

Human   171 SW-RHISPSAKPFENGQYLDIYGITRDQAGEYECSAENDVSFPDVRKVK----VVVNFAPTI--Q 228
            .| :|  ||.:.......| .:.::.:.||.|.|.|    :.|...::.    |.:..:|.|  |
  Fly   378 VWIQH--PSDRVVGTSTNL-TFSVSNETAGRYYCKA----NVPGYAEISADAYVYLKGSPAIGSQ 435

Human   229 EIKSGTVTPGRSGLIRCEGAGVPPPA-FEWYKGEKKLFNGQQ---------GIIIQNF--STRSI 281
            ..:.|.|  |.:..|.|..:.||... ..|      .||||:         .|::...  ..:|.
  Fly   436 RTQYGLV--GDTARIECFASSVPRARHVSW------TFNGQEISSESGHDYSILVDAVPGGVKST 492

Human   282 LTVTNVTQEHFGNYTCVAANKLGTTNASLPLNPPSTAQYGITGSADVLFSCWYLVLTLSSFTSIF 346
            |.:.:....|:|.|.|...|..|...|.:.|....:....:|....:....:.||||:   ..:.
  Fly   493 LIIRDSQAYHYGKYNCTVVNDYGNDVAEIQLQAKKSVSLLMTIVGGISVVAFLLVLTI---LVVV 554

Human   347 YLK 349
            |:|
  Fly   555 YIK 557

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NEGR1	NP_776169.2	IG	47..135	CDD:214652	20/91 (22%)
		IGc2	152..210	CDD:197706	18/58 (31%)
		Ig_3	225..301	CDD:372822	22/89 (25%)
rst	NP_001284835.1	IG_like	34..130	CDD:214653
		Ig	42..114	CDD:299845
		C2-set_2	135..225	CDD:285423
		Ig_3	265..329	CDD:290638	19/80 (24%)
		I-set	346..420	CDD:254352	21/80 (26%)
		Ig	360..425	CDD:299845	19/71 (27%)
		Ig5_KIRREL3-like	428..524	CDD:143235	25/103 (24%)
		IG_like	435..524	CDD:214653	23/96 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810