DRSC/TRiP Functional Genomics Resources

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Protein Alignment NEGR1 and sdk

DIOPT Version :9

Sequence 1:NP_776169.2 Gene:NEGR1 / 257194 HGNCID:17302 Length:354 Species:Homo sapiens
Sequence 2:NP_001284756.1 Gene:sdk / 31017 FlyBaseID:FBgn0021764 Length:2265 Species:Drosophila melanogaster


Alignment Length:386 Identity:78/386 - (20%)
Similarity:126/386 - (32%) Gaps:120/386 - (31%)


- Green bases have known domain annotations that are detailed below.


Human    48 MMVRKGDTAV--------LRC-------------YLEDGASKGAWLNRSSIIFAGGDKWSVDPRV 91
            ::||..|..|        |:|             :|:||.:    :..:.:.....|.|      
  Fly   263 IIVRPQDVKVKVGTGVVELQCIANARPLHELETLWLKDGLA----VETAGVRHTLNDPW------ 317

Human    92 SISTLNKRDYSLQIQNVDVTDDGPYTCSVQTQ---HTPRTMQVHLTVQVPPKIYDISNDMTVNE- 152
                    :.:|.:...:.:..|.|||.|:.:   :...:....|.:..||..:......|..| 
  Fly   318 --------NRTLALLQANSSHSGEYTCQVRLRSGGYPAVSASARLQILEPPLFFTPMRAETFGEF 374

Human   153 GTNVTLTCLATGKPEPSISW-RHISPSAKPFENGQY-------LDIYGITRDQAGEYECSAEND- 208
            |..|.|||...|:|.|.:.| |:........|:|:|       |.|..:..|.|..::|.|.|: 
  Fly   375 GGQVQLTCDVVGEPTPQVKWFRNAESVDAHIESGRYTLNTDNTLVIKKLILDDAAMFQCLAINEA 439

Human   209 ----------------------VSFPDVRKVKV--------------------VVNFAPT-IQEI 230
                                  ::.|.:.:|:.                    ...||.. |.|:
  Fly   440 GENSASTWLRVKTKTAKNRVKRLAQPRILRVRASHAGLGSEKGSESGSSDRRKEFRFASAPIMEL 504

Human   231 KSGTVT--PGRSGLIRCEGAGVPPPAFEWYKGEKKLFNGQQGIIIQNFSTRSILTVTNVTQEHFG 293
            ....||  .|:...|.|...|.|.|...|...|.:|.:....:.|.....   |.::|:.....|
  Fly   505 PPQNVTALDGKDATISCRAVGSPNPNITWIYNETQLVDISSRVQILESGD---LLISNIRSVDAG 566

Human   294 NYTCVAANKLGTTNASLPLN---------PP--STAQYGITGSADVLFSC---------WY 334
            .|.||.||:.|:......|:         ||  :|...|:|.:.....|.         ||
  Fly   567 LYICVRANEAGSVKGEAYLSVLVRTQIIQPPVDTTVLLGLTATLQCKVSSDPSVPYNIDWY 627

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NEGR1NP_776169.2 IG 47..135 CDD:214652 18/110 (16%)
IGc2 152..210 CDD:197706 21/89 (24%)
Ig_3 225..301 CDD:372822 20/78 (26%)
sdkNP_001284756.1 Ig 71..157 CDD:299845
I-set 72..150 CDD:254352
Ig 172..245 CDD:299845
IG_like 280..356 CDD:214653 14/93 (15%)
Ig 280..343 CDD:299845 13/80 (16%)
IG_like 375..450 CDD:214653 20/74 (27%)
Ig 378..447 CDD:143165 19/68 (28%)
Ig 506..587 CDD:299845 22/83 (27%)
IG_like 506..587 CDD:214653 22/83 (27%)
I-set 592..682 CDD:254352 8/36 (22%)
Ig 595..682 CDD:299845 8/33 (24%)
FN3 686..789 CDD:238020
FN3 798..893 CDD:238020
FN3 901..1005 CDD:238020
fn3 1011..1094 CDD:278470
FN3 1108..1202 CDD:238020
FN3 1210..1308 CDD:238020
fn3 1317..1402 CDD:278470
FN3 1415..1507 CDD:238020
FN3 1513..1608 CDD:238020
fn3 1617..1708 CDD:278470
FN3 1722..1823 CDD:238020
FN3 1828..1920 CDD:238020
FN3 1927..2016 CDD:238020
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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