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Protein Alignment NEGR1 and Dscam4

DIOPT Version :9

Sequence 1:	NP_776169.2	Gene:	NEGR1 / 257194	HGNCID:	17302	Length:	354	Species:	Homo sapiens
Sequence 2:	NP_001261571.1	Gene:	Dscam4 / 2769008	FlyBaseID:	FBgn0263219	Length:	1935	Species:	Drosophila melanogaster

Alignment Length:	496	Identity:	103/496 - (20%)
Similarity:	155/496 - (31%)	Gaps:	197/496 - (39%)

- Green bases have known domain annotations that are detailed below.

Human    20 VLLSLCCLLPSCLPAGQSV-DFPWAAVDN------------MMVRKGDTAVLRCYLEDGASKGAW 71
            |:|:....|| |:..|..| .:.|...:|            .:|..|...:.:..|||......|
  Fly   247 VVLNGQTTLP-CIAQGHPVPTYRWFKEENEQLLPLQLSERITIVSAGLLKITKARLEDSGKYLCW 310

Human    72 LNRSS-----------------------------------IIFAGGDKWSV-----------DPR 90
            :|.::                                   .|.:|.....|           |.|
  Fly   311 VNNTAGEETIQVSLTVTAPLTAHLQPQVQTVDVDKDAQFQCIVSGHPVHDVNWLHDGKPILRDNR 375

Human    91 VSISTLNKRDYSLQIQNVDVTDDGPYTCSV--QTQHTPRTMQVHLTVQVPPKIYDISNDMTVNEG 153
            |.|.|...|   |.|:.|...|.|.|.|.|  :.:....|.::.|....|..:|..| :.|:..|
  Fly   376 VEILTDPPR---LIIKKVQKEDPGMYQCFVSNEWEQIQSTAELQLGDASPELLYWFS-EQTLQPG 436

Human   154 TNVTLTCLATGKPEPSISWR---HISPSAKPFENGQYLDIY----------GITRDQAGEYECSA 205
            ..|:|.|:|||.|.|..:|.   ...|.:..|..|||:.|:          .:..:..|||.|:|
  Fly   437 PTVSLKCVATGNPLPQFTWSLDGFPIPDSSRFLVGQYVTIHDDVISHVNISNVKEEDGGEYTCTA 501

Human   206 ENDVSFPDVRKV----KVVVNFAPTIQEIKSGTVTPGRSGLIRCEGAGVP--------------- 251
            :|.:.     ||    ||.:...|.|:|:...|...|...:::|..||.|
  Fly   502 QNAIG-----KVSHSAKVNIYGLPYIREMPKITGISGSDLIVKCPVAGYPIDKIHWERDGQTLPI 561

Human   252 ----------------------------------------------------------------- 251

  Fly   562 NRRQRAYNNGTLIIEQLQRLEDAGTYTCMAQNKQKQTSRRNVEIQVLVPPKIMPIQAMTNMLREG 626

Human   252 --------------PPAFEWYKGEKKLFNGQQGIIIQNFSTRSILTVTNVTQEHFGNYTCVAANK 302
                          |.:|.|.:..|.|......:..:.....:.|.:.:::.:|.|||||:|:|.
  Fly   627 MRAAISCQILEGDLPVSFRWERNGKPLIGTGNEVFRRLDEYSASLVIEHISSDHSGNYTCIASNV 691

Human   303 LGTTNASLPLN---PP--------STAQYGITGSADVLFSC 332
            .||...::||.   ||        |:||.|    ||||..|
  Fly   692 AGTERFTVPLTVNVPPKWILEPKDSSAQAG----ADVLLHC 728

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.