DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NEGR1 and dpr1

DIOPT Version :9

Sequence 1:	NP_776169.2	Gene:	NEGR1 / 257194	HGNCID:	17302	Length:	354	Species:	Homo sapiens
Sequence 2:	NP_001286645.1	Gene:	dpr1 / 2768858	FlyBaseID:	FBgn0040726	Length:	367	Species:	Drosophila melanogaster

Alignment Length:	380	Identity:	80/380 - (21%)
Similarity:	135/380 - (35%)	Gaps:	103/380 - (27%)

- Green bases have known domain annotations that are detailed below.

Human    16 WLAAVLLSLCCLL---------------------PSCLPAGQSVDFPWAAVDNMMVRKGDTAVLR 59
            ||...||.|..:|                     ||.|......|.|    .|:.|..|.|..|.
  Fly    14 WLIGWLLLLSMVLLRGYNAALAPTPPTTSTTTISPSNLLPYFDFDVP----RNLTVTVGQTGFLH 74

Human    60 CYLED-GASKGAWLNRSS--IIFAGGDKWSVDPRVSISTLN-KRDYSLQIQNVDVTDDGPYTCSV 120
            |.:|. |....:|:.:..  |:.|||..::.|.|..:...: ..:::|||:.....|.|.|.|.:
  Fly    75 CRVERLGDKDVSWIRKRDLHILTAGGTTYTSDQRFQVLRPDGSANWTLQIKYPQPRDSGVYECQI 139

Human   121 QTQHTPRTMQVHLTVQVPPKIYDISNDMTVNEGTNVTLTCLATGKPEP--SISWRHISPSAKPFE 183
            .|:...........|::..:|:..| |:.|..|:::.|||.....|..  :|.|         ::
  Fly   140 NTEPKMSLSYTFNVVELKAEIFGPS-DLMVKTGSDINLTCKIMQGPHELGNIFW---------YK 194

Human   184 NGQYLDIYGITRDQAGEYECSAENDVSFPDVRKVKVVVNFAPTI-QEIKSGTVTPGRSGLIRCEG 247
            ..:.||..|             ||::. ..:.:::|..::...: ..:|.....||.:|...|
  Fly   195 GSEMLDGKG-------------ENEID-SSMARIRVEDDWTDGLTSRLKIKRAMPGDTGNYTC-- 243

Human   248 AGVPPPAFEWYKGEKKLFNGQQGIII--------QNFSTRS----------ILTVTNVTQEHFGN 294
              ||..|        |..:....:||        .|.|:.|          :|::.:...:||..
  Fly   244 --VPTVA--------KTSSVYVHVIIGEHPAAMQHNSSSNSNSFYCGICCMLLSIVSCCLQHFYE 298

Human   295 YTCVAANKLGTTNASLPLNPP-----STAQYGITGS------------ADVLFSC 332
            ..|...:.......|..|.||     :|::.||:.:            |..|.:|
  Fly   299 TGCGYLHAAAALAKSAGLGPPKRATLTTSETGISAAEVAAAAGASAAVASALATC 353

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NEGR1	NP_776169.2	IG	47..135	CDD:214652	23/91 (25%)
		IGc2	152..210	CDD:197706	12/59 (20%)
		Ig_3	225..301	CDD:372822	18/94 (19%)
dpr1	NP_001286645.1	Ig	59..154	CDD:299845	24/98 (24%)
		IG_like	60..150	CDD:214653	24/93 (26%)
		IG_like	163..257	CDD:214653	25/129 (19%)
		Ig	174..244	CDD:143165	17/96 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810