DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Igf1r and Sdr

DIOPT Version :9

Sequence 1:	XP_008757722.1	Gene:	Igf1r / 25718	RGDID:	2869	Length:	1372	Species:	Rattus norvegicus
Sequence 2:	NP_001287331.1	Gene:	Sdr / 41809	FlyBaseID:	FBgn0038279	Length:	868	Species:	Drosophila melanogaster

Alignment Length:	927	Identity:	266/927 - (28%)
Similarity:	412/927 - (44%)	Gaps:	209/927 - (22%)

- Green bases have known domain annotations that are detailed below.

  Rat    16 LVFLSAALSLWPTSGE--ICGPGIDIRNDYQQLKRLENCTVIEGFLHILLISKAEDYRSYRFPKL 78
            |:||.|:..:..:|.:  .|| .::| |....|::|:|||.:.|.:.:..:...:...:|....|
  Fly    23 LLFLGASSPVLASSDDQTACG-SLEI-NKIADLRKLQNCTHVVGHVRLAYVDLTDVSGNYSLDSL 85

  Rat    79 ----TVITEYLLLFRVAGLESLGDLFPNLTVIRGWKLFYN-YALVIFEMTNLKDIGLYNLRNITR 138
                |.|::||:::|..||.||..:||.|.:|||.:|.:: |:||::|..||:::||..|..|..
  Fly    86 ASNVTEISDYLMVYRCTGLISLQSIFPRLRIIRGQELLFDQYSLVVYENRNLRELGLVELLRIQS 150

  Rat   139 GAIRIEKNADLCYLSTIDWSLILDAVSNNY--IVGNKPPKECGDLCPGTLEEKPMCEKTTINNEY 201
            |.||:|.|..||::.|:||..::...:..:  :..|:|..:|           |:|...:.:.|:
  Fly   151 GFIRVESNPLLCFVETVDWIYLMGNATRQHFSLKHNRPQSQC-----------PLCGSLSADFEF 204

  Rat   202 ----NYRCWTTNRCQ--------KMCPSVCGKRACTENNECCHPECLGSCHTPDDNTTCVACRHY 254
                :.|||..|..|        |.||..||...|....:||...|:..|::.:    |..|.:|
  Fly   205 IRNSSERCWNVNTTQLRPQPPRLKDCPIACGLNGCDSAGKCCDHNCVTGCYSQN----CSLCANY 265

  Rat   255 YYKGVCVPACPPGTYRFEGWRCVDRDFC---ANIPNAESSDSDGFVIHDGECMQECPSGFIRNST 316
            ..:..||..| ..:|.....||:....|   ..||          :|...:|:::||.    |..
  Fly   266 QGRMGCVNQC-VASYELNKRRCIGHRECRELGRIP----------LIRGYQCVKKCPG----NQK 315

  Rat   317 QSMYC---IPCEGPCPKVCGDEEKKTKTIDSVTSAQMLQGCTILKGNL---LINIRRGNNIASEL 375
            :.:..   |.|:..|.   ||...|     |....::||.|..:.|:|   |.||:  ..|...|
  Fly   316 EILVAKGIIHCQVECN---GDFHVK-----SAADLEVLQDCVTINGSLTIELTNIK--EKIVDAL 370

  Rat   376 ENFMGLIEVVTGYVKIRHSHALVSLSFLKNLRLILGEEQLEGNYSFYVLDNQNLQQLWDWNHRNL 440
            ||.:..::.:|||:|:.||..|:||:||:||..|.|::.:|..|:.||::|.:|:.:|..||. :
  Fly   371 ENALASVKEITGYLKVIHSAQLMSLTFLQNLDAIRGDKLVENKYALYVVNNYHLEHIWPPNHL-V 434

  Rat   441 TVRSGKMYFAFNPKLCVSEIYRMEEVTGTKGRQSKGDINTRNNGERASCESDVLR--------FT 497
            .::.|.::|..||:||..:|::::....:....|..|::..:||||..| .|.:|        ..
  Fly   435 IIQRGTLFFHLNPRLCYEKIHQLQGSLKSGENISVADVSPNSNGERVIC-GDAVRSLNPKVEDLN 498

  Rat   498 STTTWKNRIIITWHRYRPPDYRD------LISFTVYYKEAPFKNVTEYDGQDACGSNSWNMVDVD 556
            ||..   |||:        ||.|      ||.::.:|||||.:|||.|||:..||.::|.|   |
  Fly   499 STAV---RIIL--------DYMDWEGMETLIGYSYHYKEAPVQNVTMYDGRHGCGHDNWLM---D 549

  Rat   557 LPPNKEGEPGILLHGLKPWTQYAVYVKAVTLTMVENDHIR-GAKSEILYIRTNASVPSIPLDVLS 620
            :.||:....  ::.||||:||||.:||  |||..|. ||: .|.|:|.|.:|....||..|.:..
  Fly   550 VVPNQSRRH--VISGLKPYTQYAYFVK--TLTRTEY-HIQIDAYSKIGYFQTLPDRPSPVLRIYG 609

  Rat   621 ASNSSSQLIVKWNPPTLPNGNLSYYIVRWQRQPQDGYLFRHNYCSKADKIPIRKYADGTIDVEEV 685
            :|..|||:::.|.||..|||.:.                  ||...|:|....|.|.....|...
  Fly   610 SSEISSQILLHWWPPRRPNGVIK------------------NYFVTAEKYNATKEAKDKNYVNVE 656

  Rat   686 TENPKTEV---CGGDKGPCCACPKTEAEKQAEKEEAEYRKVFENFLHNSIFVPRPERRRR----- 742
            .||.| ::   |.|.. |..:.|:.:.|....||:..|    |:.|.|.|:|.|....||
  Fly   657 LENAK-DIDCECAGVL-PYYSGPQPDDEDYYNKEQITY----EDALPNLIYVSRNHDYRRKEFEK 715

  Rat   743 -----DVLQVANTTMSSRSRNTTVADTYNITDPEE--FETEYPFFESRVDNKERTV--------- 791
                 .:|.:......:|...||.|.| |.|..:|  ....|..:....:.|:|.:
  Fly   716 VINYEHLLSIKKDEEPTRPPTTTPAPT-NATLAKERLAAINYENYRLNSEKKQRDLQDLDQHKYT 779

  Rat   792 ------------------------------------------ISNLRPFTLYRIDIHSCNHEAEK 814
                                                      :|.|.|.|.|||.|.:| .|...
  Fly   780 IRHALPKCQNSHASVVQQVEEKCVAEEPLSGYELPGTQHFYCLSQLEPETHYRITIRAC-VEGVV 843

  Rat   815 LGCSASNFVFARTMPAE 831
            .|||.         |||
  Fly   844 NGCST---------PAE 851

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Igf1r	XP_008757722.1	Recep_L_domain	51..161	CDD:279382	42/114 (37%)
		Furin-like	175..330	CDD:279142	39/172 (23%)
		TNFRSF	207..336	CDD:304602	34/142 (24%)
		FU	230..277	CDD:238021	12/46 (26%)
		Recep_L_domain	353..467	CDD:279382	41/116 (35%)
		FN3	494..607	CDD:238020	49/127 (39%)
		FN3	612..>656	CDD:238020	13/43 (30%)
		FN3	837..926	CDD:238020
		PTKc_InsR_like	994..1271	CDD:173625
		Pkinase_Tyr	1001..1266	CDD:285015
Sdr	NP_001287331.1	Recep_L_domain	58..173	CDD:279382	42/114 (37%)
		Furin-like	209..332	CDD:279142	35/144 (24%)
		Recep_L_domain	347..461	CDD:279382	41/116 (35%)
		FN3	491..578	CDD:214495	40/104 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	84	1.000	Domainoid score	I8051
eggNOG	1	0.900	-	-		E2759_KOG4258
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D120934at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820