Protein Alignment Gucy2c and Gyc76C

DIOPT Version :9

• Sequence 1: NP_037302.1
• Gene: Gucy2c / 25711
• RGDID: 2771
• Length: 1072
• Species: Rattus norvegicus
• Sequence 2: NP_001163473.1
• Gene: Gyc76C / 8674026
• FlyBaseID: FBgn0266136
• Length: 1525
• Species: Drosophila melanogaster
• Alignment Length: 1199
• Identity: 340/1199 - (28%)
• Similarity: 521/1199 - (43%)
• Gaps: 291/1199 - (24%)

  Rat    56 AVEEGLDIVRK---RLREAELNVTVNATFIYSDGLIHKSGDCRSST-------CEGLDLLREITR 110
            |:...||.|.|   .|....|::..|.|          .||...:|       |:|:
  Fly    49 ALTMALDEVNKDPNLLPNVYLDLRWNDT----------KGDTVLATKAITEMICDGI-------- 95

  Rat   111 DRKMGCVLMGPS--CTYSTFQMYLDTELNYPMISAGSFGLSC-DYK----ETLTRILPPARKLMY 168
                 ..:.||.  |   ..:..:....|.||||     ..| :|:    .|..|..||..:::.
  Fly    96 -----ATIFGPEGPC---YVEAIVSQSRNIPMIS-----YKCAEYRASAIPTFARTEPPDTQVVK 147

  Rat   169 FLVDFWKVNNAPFKTFSWNS-SYVYKNGSEPE--------------------------------- 199
            .|:       |..:.::||. |.:|::...|.
  Fly   148 SLL-------ALLRYYAWNKFSILYEDVWSPVADLLKDQATKRNMTINHKQSFIDNRVKCCEQML 205

  Rat   200 DC----FWY---------------LNALEAGVSYFSE------------VLSFKDVLRRSEQFQE 233
            ||    :||               |.|..:.|.:.|.            ::.|.|::..||:..|
  Fly   206 DCCRSGYWYQLVQNTMNRTRIYVFLGAANSLVDFMSSMETAGLFARGEYMVIFVDMMVYSEREAE 270

  Rat   234 ILMGRNRKSNVIVMCGTPETFYNVKGDLKVADDTVVILVDLFSNHYFEDDTRAPEYMDNVLVLTL 298
            ..:.|..:...:..|.:.|.|..:...|.|...|..      :..|.:...:..:|...
  Fly   271 KYLRRVDQITFMSNCHSTENFNQMARSLLVVASTPP------TKDYIQFTKQVQKYSSK------ 323

  Rat   299 PPEKF-IANASVSGRFPSERSDFSLAYLEGTLLFGHMLQTFLENGESVTTPK--FARA------- 353
            ||... |....|...|....|.::....:...|:...:...|.....|.|..  |..|
  Fly   324 PPFNLEIPRLFVESNFSKFISIYAAYLYDSVKLYAWAVDKMLREETRVLTDDVIFEVASNGTRVI 388

  Rat   354 ---FRNLTFQGLEG-PVTLDDSGDIDNIMCLLYVSLDTRKYKVLMAYDTHK-NQT---------I 404
               .:|.|:..:.| .:.:|..||.:.            .:.|| ||..|| |.:         :
  Fly   389 DTIIKNRTYMSITGSKIKIDQYGDSEG------------NFSVL-AYKPHKWNNSNNMPCNYHMV 440

  Rat   405 PVA------TSPNFIWKNHRL--------PNDVPGLGPQILMIAVF--------------TLTGI 441
            |||      ..|.:...|..:        |.|.|..|        |              |:..:
  Fly   441 PVAYFHQGEEHPEYKLINGSIDWPSGGEKPADEPMCG--------FANELCKKDDTHYTSTVAAV 497

  Rat   442 VVVLLL-----IALLVLRKYRRDHELRQKKWSHIPSENIFPLETNE----TNHVSLK-------- 489
            |:.:||     |.:.:.||::.:.|:....|...|:| |.....||    .:.|||.
  Fly   498 VLGVLLFCSGVITMSIYRKWKIELEIEGLLWKIDPNE-IKGYSGNEIVSSPSKVSLMSAQSYGSR 561

  Rat   490 ------IDDDRRRDTIQRVRQCKYDKKKVILKDLKHCDGNFSEKQKIELNKLLQSDYYNLTKFYG 548
                  ....|.|..:.|:::.|:.:|:.|.:::         .:::.|.:.|:.|  |:..|.|
  Fly   562 WTNQFVTSTGRLRGAVVRIKELKFPRKRDISREI---------MKEMRLLRELRHD--NINSFIG 615

  Rat   549 TVKLDTRIFGVVEYCERGSLREVL-NDTISYPDGTFMDWEFKISVLNDIAKGMSYLHSSKIEVHG 612
            .....|||..|.:||.:|||.::: |:.|.      :|..|..|:::|:.|||.|:|:|::..||
  Fly   616 ASVEPTRILLVTDYCAKGSLYDIIENEDIK------LDDLFIASLIHDLIKGMIYIHNSQLVYHG 674

  Rat   613 RLKSTNCVVDSRMVVKITDFGCNSILP------------PKKDLWTAPEHLRQATI-SQKGDVYS 664
            .|||:||||.||.::::||||.:.:..            .:..||.|||.||.... |||||||:
  Fly   675 NLKSSNCVVTSRWMLQVTDFGLHELRQCAENESIGEHQHYRNQLWRAPELLRNHIHGSQKGDVYA 739

  Rat   665 FSIIAQEIILRKETFYTLSCRDQNEKIFRVEN--SYGTKPFRPDLFLETADEKE-LEVYLL--VK 724
            |:||..||..||..|..::. :..|.:..|:.  ..|..||||:  :|:..|.| ...|:|  ::
  Fly   740 FAIIMYEIFSRKGPFGQINF-EPKEIVDYVKKLPLKGEDPFRPE--VESIIEAESCPDYVLACIR 801

  Rat   725 SCWEEDPEKRPDFKKIESTLAKIFGLFHDQKNESYMDTLIRRLQLYSRNLEHLVEERTQLYKAER 789
            .||.||||:||:|..|.:.|.|:.|    .|.::.||.::..::.|:.|||.:|.|||:|...|:
  Fly   802 DCWAEDPEERPEFSVIRNRLKKMRG----GKTKNIMDQMMEMMEKYANNLEDIVTERTRLLCEEK 862

  Rat   790 DRADHLNFMLLPRLVVKSLKEKGIVEPELYEEVTIYFSDIVGFTTICKYSTPMEVVDMLNDIYKS 854
            .:.:.|...:||:.|.:.|.....|||..|:.||||||||||||.:...|||::||:.|||:|..
  Fly   863 MKTEDLLHRMLPQSVAEKLTMGQGVEPVSYDLVTIYFSDIVGFTAMSAESTPLQVVNFLNDLYTV 927

  Rat   855 FDQIVDHHDVYKVETIGDAYVVASGLPMRNGNRHAVDISKMALDILSFMGTFELEHLPGLPVWIR 919
            ||:|:..:||||||||||||:|.||||::||:|||.:|:.|||::|..:....:.|.|...:.:|
  Fly   928 FDRIIRGYDVYKVETIGDAYMVVSGLPIKNGDRHAGEIASMALELLHAVKQHRIAHRPNETLKLR 992

  Rat   920 IGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGLPLRIHMSSSTIAILRRTDCQFLYEVRG 984
            ||:|:||..|||||:.|||||||||||||||||||.|..|:||:|:.....|.:....::.|.||
  Fly   993 IGMHTGPVVAGVVGLTMPRYCLFGDTVNTASRMESNGEALKIHISNKCKLALDKLGGGYITEKRG 1057

  Rat   985 ETYLKGRGTETTYWLTGMKDQEYN------LPTPPTVENQQRLQTEFS-DMIVSALQKRQASGVK 1042
            ...:||:|...|:||||..:....      :..||.:.::.|...:.: |....::|.....|..
  Fly  1058 LVNMKGKGDVVTWWLTGANENAIQKKLVDMMDMPPPLFSRPRKSPKLNPDSRQPSIQAMHFCGTG 1122

  Rat  1043 SRRPTRVASYKKGFLEYMQLNNSDHDSTY 1071
            |||.:.|.            ...|.:|||
  Fly  1123 SRRQSTVP------------RAMDGESTY 1139

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gucy2c	NP_037302.1	Periplasmic_Binding_Protein_Type_1	34..414	CDD:299141	86/469 (18%)
		PKc_like	479..749	CDD:304357	99/306 (32%)
		STYKc	501..744	CDD:214568	90/261 (34%)
		CYCc	787..978	CDD:214485	99/190 (52%)
		Guanylate_cyc	814..1001	CDD:278633	102/186 (55%)
Gyc76C	NP_001163473.1	PBP1_Speract_GC_like	26..445	CDD:107365	85/458 (19%)
		ANF_receptor	48..412	CDD:279440	73/412 (18%)
		PK_GC-A_B	543..827	CDD:270944	98/307 (32%)
		HNOBA	<835..881	CDD:285003	14/45 (31%)
		CYCc	860..1052	CDD:214485	99/191 (52%)
		Guanylate_cyc	887..1074	CDD:278633	102/186 (55%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810