DRSC/TRiP Functional Genomics Resources

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Protein Alignment GAD1 and Sply

DIOPT Version :10

Sequence 1:NP_000808.2 Gene:GAD1 / 2571 HGNCID:4092 Length:594 Species:Homo sapiens
Sequence 2:NP_652032.1 Gene:Sply / 46059 FlyBaseID:FBgn0010591 Length:545 Species:Drosophila melanogaster


Alignment Length:519 Identity:109/519 - (21%)
Similarity:186/519 - (35%) Gaps:103/519 - (19%)


- Green bases have known domain annotations that are detailed below.


Human    97 NLFARDLLPAKNGEEQTVQFLLEV------VDILLNYVRKTFDRSTKVLDFHHPHQLLEGMEGFN 155
            ||:.|       |:.|..:|..::      |:..|...:..|:...|..:.|..         ::
  Fly    52 NLYIR-------GKRQFFKFAKKIPAVRRQVETELAKAKNDFETEIKKSNAHLT---------YS 100

Human   156 LELSDHPESLEQILVDCRDTLKYGVRTGHPRFFNQLSTGL------DIIGLAGEWLTSTANTNMF 214
            ..|.:...|.|:||....:.||    |||..:.:...:|.      |::.|..|.....:.||..
  Fly   101 ETLPEKGLSKEEILRLVDEHLK----TGHYNWRDGRVSGAVYGYKPDLVELVTEVYGKASYTNPL 161

Human   215 TYEIAPVFVLMEQITLKKMREIVGWSSKDGDGIFSPGGAISNMYSIMAARYKYFPEVK--TKGMA 277
            ..::.|....||...::....:...:|. ..|..:.||..|.:.::.|.| .:..|.|  |:...
  Fly   162 HADLFPGVCKMEAEVVRMACNLFHGNSA-SCGTMTTGGTESIVMAMKAYR-DFAREYKGITRPNI 224

Human   278 AVPKLVLFTSEQSHYSIKKAGAALGFGTDNVILIKCNERGKIIPADFEAKILEAKQKGYVPFYVN 342
            .|||.|       |.:..|.|........:|         .:.|..:|..|.:.|:.      :|
  Fly   225 VVPKTV-------HAAFDKGGQYFNIHVRSV---------DVDPETYEVDIKKFKRA------IN 267

Human   343 -------ATAGTTVYGAFDPIQEIADICEKYNLWLHVDAAWGGGLL-MSRKHRHKLN----GIER 395
                   .:|....||..|.|:.||.:..||::.:||||..|..:: :.|...:||.    .::.
  Fly   268 RNTILLVGSAPNFPYGTIDDIEAIAALGVKYDIPVHVDACLGSFVVALVRNAGYKLRPFDFEVKG 332

Human   396 ANSVTWNPHKMMGVLLQCSAILVKEKGILQGCNQMCAGYLFQPDKQYDVSYD-----TGDKAIQC 455
            ..|::.:.||........|.||..:|.              ..|.|:.|:.|     .|...:..
  Fly   333 VTSISADTHKYGFAPKGSSVILYSDKK--------------YKDHQFTVTTDWPGGVYGSPTVNG 383

Human   456 GRHVDIF-KFWLMWKAKGTVGFENQINKCLELAEYLYAKIKNREEFEMVFNGEPEHTNVCFWYIP 519
            .|...|. ..|....:.|..|:.....:.::.|.|:...:::.:.. .:| |:|..:.:...   
  Fly   384 SRAGGIIAACWATMMSFGYDGYLEATKRIVDTARYIERGVRDIDGI-FIF-GKPATSVIALG--- 443

Human   520 QSLRGVPDSPQRREKLHKVAPKIKALMMESG----TTMVGYQPQGDKANFFRMVISNPAATQSD 579
               ..|.|..:..:.|.|:...:.||...||    .|.:..|| |....|...|.|..|....|
  Fly   444 ---SNVFDIFRLSDSLCKLGWNLNALQFPSGIHLCVTDMHTQP-GVADKFIADVRSCTAEIMKD 503

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GAD1NP_000808.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..23
Pyridoxal_deC 144..518 CDD:395219 81/399 (20%)
SplyNP_652032.1 DOPA_deC_like 132..494 CDD:99743 84/408 (21%)
Blue background indicates that the domain is not in the aligned region.

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