DRSC/TRiP Functional Genomics Resources

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Protein Alignment GAD1 and Gad1

DIOPT Version :9

Sequence 1:NP_000808.2 Gene:GAD1 / 2571 HGNCID:4092 Length:594 Species:Homo sapiens
Sequence 2:NP_001261396.1 Gene:Gad1 / 38484 FlyBaseID:FBgn0004516 Length:510 Species:Drosophila melanogaster


Alignment Length:501 Identity:288/501 - (57%)
Similarity:367/501 - (73%) Gaps:11/501 - (2%)


- Green bases have known domain annotations that are detailed below.


Human    98 LFARDLLPAK-NGEEQTVQFLLEVVDILLNYVRKTFDRSTKVLDFHHPHQLLEGMEGFNLELSDH 161
            |.|.||:|.. ....:|.:|||:|:|:||::|:.|.||:.||||||||..:...::   |::.|.
  Fly    17 LTAYDLMPTTVTAGPETREFLLKVIDVLLDFVKATNDRNEKVLDFHHPEDMKRLLD---LDVPDR 78

Human   162 PESLEQILVDCRDTLKYGVRTGHPRFFNQLSTGLDIIGLAGEWLTSTANTNMFTYEIAPVFVLME 226
            ...|:|::.||..||||.|:||||.||||||.|||:|.:||||||:|||||||||||||||:|||
  Fly    79 ALPLQQLIEDCATTLKYQVKTGHPHFFNQLSNGLDLISMAGEWLTATANTNMFTYEIAPVFILME 143

Human   227 QITLKKMREIVGWSSKDGDGIFSPGGAISNMYSIMAARYKYFPEVKTKGMAAVP-KLVLFTSEQS 290
            .:.|.|||||:|||.  ||.|.:|||:|||:|:.:|||:|.||..|..|...:| .||:|||:|.
  Fly   144 NVVLTKMREIIGWSG--GDSILAPGGSISNLYAFLAARHKMFPNYKEHGSVGLPGTLVMFTSDQC 206

Human   291 HYSIKKAGAALGFGTDNVILIKCNERGKIIPADFEAKILEAKQKGYVPFYVNATAGTTVYGAFDP 355
            |||||...|..|.|||:.|::..:|.||:|.::.|..|||.|.||.:||:|||||||||.||||.
  Fly   207 HYSIKSCAAVCGLGTDHCIVVPSDEHGKMITSELERLILERKAKGDIPFFVNATAGTTVLGAFDD 271

Human   356 IQEIADICEKYNLWLHVDAAWGGGLLMSRKHRH-KLNGIERANSVTWNPHKMMGVLLQCSAILVK 419
            |..|||||:|||.|:|:|||||||||||||||| :..|:|||:||||||||:||.|||||.|..|
  Fly   272 INTIADICQKYNCWMHIDAAWGGGLLMSRKHRHPRFTGVERADSVTWNPHKLMGALLQCSTIHFK 336

Human   420 EKGILQGCNQMCAGYLFQPDKQYDVSYDTGDKAIQCGRHVDIFKFWLMWKAKGTVGFENQINKCL 484
            |.|:|..||||.|.|||..|||||:|||||||.||||||.||||.||.|:||||.|||.|.::.:
  Fly   337 EDGLLISCNQMSAEYLFMTDKQYDISYDTGDKVIQCGRHNDIFKLWLQWRAKGTEGFEQQQDRLM 401

Human   485 ELAEYLYAKIKNR-EEFEMVFNGEPEHTNVCFWYIPQSLRGVPDSPQRREKLHKVAPKIKALMME 548
            ||.:|...:|:.: :.|.::.  |||..||.|||:|:.|||||...::..:|.|:.|.||..||:
  Fly   402 ELVQYQLKRIREQSDRFHLIL--EPECVNVSFWYVPKRLRGVPHDAKKEVELGKICPIIKGRMMQ 464

Human   549 SGTTMVGYQPQGDKANFFRMVISNPAATQSDIDFLIEEIERLGQDL 594
            .||.||||||...:.||||.:||:.|..::|:||:::||.|||.||
  Fly   465 KGTLMVGYQPDDRRPNFFRSIISSAAVNEADVDFMLDEIHRLGDDL 510

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GAD1NP_000808.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..23
Pyridoxal_deC 144..518 CDD:365998 225/376 (60%)
Substrate binding 190..192 1/1 (100%)
Gad1NP_001261396.1 Pyridoxal_deC 64..434 CDD:395219 225/376 (60%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165144948
Domainoid 1 1.000 472 1.000 Domainoid score I450
eggNOG 1 0.900 - - E1_COG0076
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H635
Inparanoid 1 1.050 595 1.000 Inparanoid score I973
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG62386
OrthoDB 1 1.010 - - D162307at33208
OrthoFinder 1 1.000 - - FOG0000667
OrthoInspector 1 1.000 - - otm40889
orthoMCL 1 0.900 - - OOG6_100596
Panther 1 1.100 - - O PTHR45677
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4534
SonicParanoid 1 1.000 - - X464
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1615.800

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