DRSC/TRiP Functional Genomics Resources

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Protein Alignment GAD1 and Gad1

DIOPT Version :10

Sequence 1:NP_000808.2 Gene:GAD1 / 2571 HGNCID:4092 Length:594 Species:Homo sapiens
Sequence 2:NP_523914.2 Gene:Gad1 / 38484 FlyBaseID:FBgn0004516 Length:510 Species:Drosophila melanogaster


Alignment Length:501 Identity:288/501 - (57%)
Similarity:367/501 - (73%) Gaps:11/501 - (2%)


- Green bases have known domain annotations that are detailed below.


Human    98 LFARDLLPAK-NGEEQTVQFLLEVVDILLNYVRKTFDRSTKVLDFHHPHQLLEGMEGFNLELSDH 161
            |.|.||:|.. ....:|.:|||:|:|:||::|:.|.||:.||||||||..:...::   |::.|.
  Fly    17 LTAYDLMPTTVTAGPETREFLLKVIDVLLDFVKATNDRNEKVLDFHHPEDMKRLLD---LDVPDR 78

Human   162 PESLEQILVDCRDTLKYGVRTGHPRFFNQLSTGLDIIGLAGEWLTSTANTNMFTYEIAPVFVLME 226
            ...|:|::.||..||||.|:||||.||||||.|||:|.:||||||:|||||||||||||||:|||
  Fly    79 ALPLQQLIEDCATTLKYQVKTGHPHFFNQLSNGLDLISMAGEWLTATANTNMFTYEIAPVFILME 143

Human   227 QITLKKMREIVGWSSKDGDGIFSPGGAISNMYSIMAARYKYFPEVKTKGMAAVP-KLVLFTSEQS 290
            .:.|.|||||:|||.  ||.|.:|||:|||:|:.:|||:|.||..|..|...:| .||:|||:|.
  Fly   144 NVVLTKMREIIGWSG--GDSILAPGGSISNLYAFLAARHKMFPNYKEHGSVGLPGTLVMFTSDQC 206

Human   291 HYSIKKAGAALGFGTDNVILIKCNERGKIIPADFEAKILEAKQKGYVPFYVNATAGTTVYGAFDP 355
            |||||...|..|.|||:.|::..:|.||:|.::.|..|||.|.||.:||:|||||||||.||||.
  Fly   207 HYSIKSCAAVCGLGTDHCIVVPSDEHGKMITSELERLILERKAKGDIPFFVNATAGTTVLGAFDD 271

Human   356 IQEIADICEKYNLWLHVDAAWGGGLLMSRKHRH-KLNGIERANSVTWNPHKMMGVLLQCSAILVK 419
            |..|||||:|||.|:|:|||||||||||||||| :..|:|||:||||||||:||.|||||.|..|
  Fly   272 INTIADICQKYNCWMHIDAAWGGGLLMSRKHRHPRFTGVERADSVTWNPHKLMGALLQCSTIHFK 336

Human   420 EKGILQGCNQMCAGYLFQPDKQYDVSYDTGDKAIQCGRHVDIFKFWLMWKAKGTVGFENQINKCL 484
            |.|:|..||||.|.|||..|||||:|||||||.||||||.||||.||.|:||||.|||.|.::.:
  Fly   337 EDGLLISCNQMSAEYLFMTDKQYDISYDTGDKVIQCGRHNDIFKLWLQWRAKGTEGFEQQQDRLM 401

Human   485 ELAEYLYAKIKNR-EEFEMVFNGEPEHTNVCFWYIPQSLRGVPDSPQRREKLHKVAPKIKALMME 548
            ||.:|...:|:.: :.|.::.  |||..||.|||:|:.|||||...::..:|.|:.|.||..||:
  Fly   402 ELVQYQLKRIREQSDRFHLIL--EPECVNVSFWYVPKRLRGVPHDAKKEVELGKICPIIKGRMMQ 464

Human   549 SGTTMVGYQPQGDKANFFRMVISNPAATQSDIDFLIEEIERLGQDL 594
            .||.||||||...:.||||.:||:.|..::|:||:::||.|||.||
  Fly   465 KGTLMVGYQPDDRRPNFFRSIISSAAVNEADVDFMLDEIHRLGDDL 510

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GAD1NP_000808.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..23
Pyridoxal_deC 144..518 CDD:395219 225/376 (60%)
Gad1NP_523914.2 Pyridoxal_deC 64..434 CDD:395219 225/376 (60%)
Blue background indicates that the domain is not in the aligned region.

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