DRSC/TRiP Functional Genomics Resources

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Protein Alignment GAD1 and Hdc

DIOPT Version :10

Sequence 1:NP_000808.2 Gene:GAD1 / 2571 HGNCID:4092 Length:594 Species:Homo sapiens
Sequence 2:NP_523679.2 Gene:Hdc / 36076 FlyBaseID:FBgn0005619 Length:847 Species:Drosophila melanogaster


Alignment Length:515 Identity:126/515 - (24%)
Similarity:205/515 - (39%) Gaps:133/515 - (25%)


- Green bases have known domain annotations that are detailed below.


Human    67 FKE-RQSSKNLLS-----CENSDRDARFRRTETDFSNLFARDLLPAK---NGEEQTVQFLLEVVD 122
            ||| ||..|.::.     .||    .|.||...|.|..:.|.|||..   .||...         
  Fly     3 FKEYRQRGKEMVDYIADYLEN----IRERRVFPDVSPGYMRQLLPESAPIEGEPWP--------- 54

Human   123 ILLNYVRKTFDRSTKVLDFHHPHQLLEGMEGFNLELSDHPESLEQILVDCRDTLKYGVRTGHPRF 187
                   |.|....:::           |.|.....|.|..:                      :
  Fly    55 -------KIFSDVERIV-----------MPGITHWQSPHMHA----------------------Y 79

Human   188 FNQLSTGLDIIGLAGEWLTSTANTNMFTYEIAPVFVLMEQITLKKMREIVGW--------SSKDG 244
            |..|::   :..|.|:.|....|...||:..:|....:|.|.:..:.:::|.        |...|
  Fly    80 FPALNS---MPSLLGDMLADAINCLGFTWASSPACTELEIIVMNWLGKMIGLPDAFLHLSSQSQG 141

Human   245 DGIFSPGGAISNMYSIMAAR-------YKYFPEVKTKGMAAVPKLVLFTSEQSHYSIKKAGAALG 302
            .|:.....:.:.:..::|.|       ::..|..:...:.|  :||.:.|:|:|.|::|| |.:|
  Fly   142 GGVLQTTASEATLVCLLAGRTRAIQRFHERHPGYQDAEINA--RLVAYCSDQAHSSVEKA-ALIG 203

Human   303 F-------GTDNVILIKCNERGKIIPADFEAKILEAKQKGYVPFYVNATAGTTVYGAFDPIQEIA 360
            .       ..|::.:     |||::....|..|    ::|.|||:|.||.|||...:||.::||.
  Fly   204 LVRMRYIEADDDLAM-----RGKLLREAIEDDI----KQGLVPFWVCATLGTTGSCSFDNLEEIG 259

Human   361 DICEKYNLWLHVDAAWGGGLLMSRKHRHKLNGIERANSVTWNPHKMMGVLLQCSAILVKEKGILQ 425
            .:|.:::||||||||:.|...:..:.|..|.|||||:|:.:||.|.:.|....:|:.|::...:.
  Fly   260 IVCAEHHLWLHVDAAYAGSAFICPEFRTWLRGIERADSIAFNPSKWLMVHFDATALWVRDSTAVH 324

Human   426 GCNQMCAGYLFQPDKQYD---VSYDTGDKAIQCGRHVDIFKFWLMWKAKGTVGFENQINKCLELA 487
            ....:...||     |::   |:.|.....|...|.....|.|.:.::.|..|.:..|.:.:.||
  Fly   325 RTFNVEPLYL-----QHENSGVAVDFMHWQIPLSRRFRALKVWFVLRSYGIKGLQRHIREGVRLA 384

Human   488 EYLYAKIKNREEFEM---------VF--NGEPEHTNV------------CFWYIPQSLRG 524
            :...|.:.....||:         ||  .|:.|.|..            |   ||.||:|
  Fly   385 QKFEALVLADHRFELPAKRHLGLVVFRIRGDNEITEKLLKRLNHRGNLHC---IPSSLKG 441

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GAD1NP_000808.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..23
Pyridoxal_deC 144..518 CDD:395219 100/421 (24%)
HdcNP_523679.2 Pyridoxal_deC 35..413 CDD:395219 104/446 (23%)
Blue background indicates that the domain is not in the aligned region.

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